Short- and long-term dopamine depletion causes enhanced beta oscillations in the cortico-basal ganglia loop of parkinsonian rats

Beck, Maximilian Heinz; Haumesser, Jens K.; Kühn, Johanna; Altschüler, Jennifer; Kühn, Andrea A.; Riesen, Christoph van

doi:10.1016/j.expneurol.2016.10.005

Cited by 37 publications

(29 citation statements)

References 77 publications

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“…In the case of the beta frequency range, there is a growing evidence that enhanced beta oscillations appear in patients with Parkinson disease (PD) 61 . A number of investigations found that a power increase of the beta frequency band correlates with the severity of parkinsonian motor symptoms such as akinesia and rigidity 62,63 .…”

Section: Discussionmentioning

confidence: 99%

Power-spectra and cross-frequency coupling changes in visual and Audio-visual acquired equivalence learning

Puszta

Pertich

Katona

et al. 2019

Sci Rep

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The three phases of the applied acquired equivalence learning test, i.e. acquisition, retrieval and generalization, investigate the capabilities of humans in associative learning, working memory load and rule-transfer, respectively. Earlier findings denoted the role of different subcortical structures and cortical regions in the visual test. However, there is a lack of information about how multimodal cues modify the EEG-patterns during acquired equivalence learning. To test this we have recorded EEG from 18 healthy volunteers and analyzed the power spectra and the strength of cross-frequency coupling, comparing a unimodal visual-guided and a bimodal, audio-visual-guided paradigm. We found that the changes in the power of the different frequency band oscillations were more critical during the visual paradigm and they showed less synchronized activation compared to the audio-visual paradigm. These findings indicate that multimodal cues require less prominent, but more synchronized cortical contribution, which might be a possible biomarker of forming multimodal associations.

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Section: Discussionmentioning

confidence: 99%

Power-spectra and cross-frequency coupling changes in visual and Audio-visual acquired equivalence learning

Puszta

Pertich

Katona

et al. 2019

Sci Rep

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“…Using Parkinson's mouse models, which are produced by disrupting the dopaminergic pathway with toxins such as MPTP [4] or 6-OHDA [37], various studies showed issues within the basal ganglia. One study using Parkinson's mouse model showed beta oscillations in the cortico-basal ganglia loop, whose reduction seemed to correlate with alleviation of Parkinson's motor symptoms [3839]. Other studies revealed alteration of glutamatergic neurotransmissions in the striatum and subthalamic nucleus of Parkinson's models [40].…”

Section: Discussionmentioning

confidence: 99%

Generation of Mouse Basal Ganglia Diffusion Tractography Using 9.4T MRI

Shim

Kim

et al. 2019

Exp Neurobiol

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Over the years, diffusion tractography has seen increasing use for comparing minute differences in connectivity of brain structures in neurodegenerative diseases and treatments. Studies on connectivity between basal ganglia has been a focal point for studying the effects of diseases such as Parkinson's and Alzheimer's, as well as the effects of treatments such as deep brain stimulation. Additionally, in previous studies, diffusion tractography was utilized in disease mouse models to identify white matter alterations, as well as biomarkers that occur in the progression of disease. However, despite the extensive use of mouse models to study model diseases, the structural connectivity of the mouse basal ganglia has been inadequately explored. In this study, we present the methodology of segmenting the basal ganglia of a mouse brain, then generating diffusion tractography between the segmented basal ganglia structures. Additionally, we compare the relative levels of connectivity of connecting fibers between each basal ganglia structure, as well as visualize the shapes of each connection. We believe that our results and future studies utilizing diffusion tractography will be beneficial for properly assessing some of the connectivity changes that are found in the basal ganglia of various mouse models.

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“…In vivo electrophysiological recordings were made as previously described 25 . In brief, anesthesia was induced and maintained with urethane (1.3 g/kg i.p., Sigma–Aldrich, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…We focused our analysis on activated states (AS) that are characterized by fast, low amplitude signals that have been found to resemble oscillatory activity in the awake state independent of movement artifacts and motivational states 27 , 29 , 30 . 50-second periods of an AS was selected visually as described previously 25 , 31 (for more detailed description and representative depiction of the raw signal see supplementary material). The same time segments were also used for analysis of LFPs from the NAC and the VTA.…”

Section: Methodsmentioning

confidence: 99%

High-fat diet-induced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop

Maurer

Tang

Haumesser

et al. 2017

Sci Rep

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The concept of brain circuit disorders has been proposed for a variety of neuropsychiatric diseases, characterized by pathological disturbances of neuronal networks including changes in oscillatory signaling of re-entrant cortico-subcortical loops in the basal ganglia system. Parts of this circuitry play a pivotal role in energy homeostasis. We therefore investigated whether high-fat diet (HFD) induced obesity is associated with changes in oscillatory signaling in the limbic cortico-basal ganglia loop. We performed multi-site in-vivo electrophysiological recordings of local field potentials within this network under urethane anesthesia in adult rats after 4 weeks of HFD feeding compared to age-matched controls. Recordings were performed at baseline and during systemic glucose challenge. Our analysis demonstrates increased oscillatory beta power in the nucleus accumbens (NAC) associated with decreased beta coherence between cortex and NAC in animals fed a HFD. Spontaneous beta oscillatory power strongly correlated with endocrine markers of obesity. The glucose challenge increased beta oscillations in control animals but not in animals receiving the HFD. Furthermore direct intracerebroventricular insulin injection increased beta oscillations in the NAC. The present study provides evidence for aberrant oscillatory signaling in the limbic cortico-basal ganglia loop that might contribute to the dysfunctional information processing in obesity.

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Short- and long-term dopamine depletion causes enhanced beta oscillations in the cortico-basal ganglia loop of parkinsonian rats

Cited by 37 publications

References 77 publications

Power-spectra and cross-frequency coupling changes in visual and Audio-visual acquired equivalence learning

Power-spectra and cross-frequency coupling changes in visual and Audio-visual acquired equivalence learning

Generation of Mouse Basal Ganglia Diffusion Tractography Using 9.4T MRI

High-fat diet-induced obesity and insulin resistance are characterized by differential beta oscillatory signaling of the limbic cortico-basal ganglia loop

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