Short and inflamed cervix predicts spontaneous preterm birth (COLIBRI study)

Raiche, Evelyne; Ouellet, Annie; Berthiaume, Maryse; Rousseau, Éric; Pasquier, Jean-Charles

doi:10.3109/14767058.2013.847917

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…This included significant differences in IL-6, IL-8, IL-10, TNF-α, and CRP between women who delivered preterm versus full-term. This is consistent with previous research findings on higher levels of CVF IL-8 associated with gestational age, 12 spontaneous preterm birth, 13 and, among women with preterm labor and without PPROM, delivery within 7 days. 14 One study found no association between CVF IL-8 and cervical shortening at 20 or 24 weeks' gestation; 15 given the difference between this result and our present findings, changes in IL-8 may be better detected later in pregnancy, or may be associated with other symptoms of preterm birth.…”

Section: Discussionsupporting

confidence: 93%

Comparison of Serum and Cervical Cytokine Levels throughout Pregnancy between Preterm and Term Births

Ashford

Chavan

Wiggins

et al. 2018

AJP Rep

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Objective To assess differences in cytokine levels in cervicovaginal fluid (CVF) and serum across trimesters between women with preterm births (PTBs) and full-term births. Study Design This multicenter study enrolled 302 women with a singleton gestation. CVF and serum cytokines, interleukin 1α (IL-1α), IL-1β, IL-6, IL-8, IL-10, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, and matrix metalloproteinase (MMP)-8, were measured. Women with at least one cytokine assessment and noted PTB status in their medical record were retained in the study ( N = 272). Data were analyzed using mixed modeling (main effects of PTBs and time/trimester). Results For the CVF values of IL-6, IL-8, IL-10, TNF-α, and CRP, and serum MMP-8, those who delivered preterm had significantly higher values than the full-term group regardless of trimester. For the serum values of IL-1β, IL-6, and TNF-α, those delivering preterm had significantly lower values than those delivering full-term regardless of trimester. For IL-1β in CVF, the cytokine was significantly higher in the PTB group for second and third trimesters only, relative to the full-term group. Conclusion For each CVF cytokine that differed by birth status, values were higher for PTB than term, averaged over trimester. Numerous cytokine profiles varied across trimesters in women delivering term versus preterm in both CVF and serum.

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Section: Discussionsupporting

confidence: 93%

Comparison of Serum and Cervical Cytokine Levels throughout Pregnancy between Preterm and Term Births

Ashford

Chavan

Wiggins

et al. 2018

AJP Rep

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“…Similar to the previous studies, 2 , 18 , 22 , 30 we found that individual cytokines in CVF and sonographic cervical length have an independent relation in predicting delivery within 7 days, and thus multiple marker combinations have better overall diagnostic performance than any of the individual markers. In this respect, a combination of CVF IL‐8 and cervical length is the best prediction test combination for impending preterm delivery, yielding the highest specificity (92%), although its sensitivity (56%) is not quite good.…”

Section: Discussionsupporting

confidence: 90%

Prediction of impending preterm delivery based on sonographic cervical length and different cytokine levels in cervicovaginal fluid in preterm labor

Jung

Park

Ryu

et al. 2015

J of Obstet and Gynaecol

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“…Interleukin-8 (IL-8) is a chemokine that targets neutrophils to promote their chemotaxis and activation as well as induce reactive oxygen species (ROS) (5). Its presence in cervico-vaginal fl uid has been associated with cervical dilation, preterm labor, labor at term, cervico-vaginal infection, amniotic fl uid infection, chorioamnionitis and adverse cerclage outcome (6)(7)(8)(9)(10)(11). The inducible 70kDa heat shock protein (HSPA1A), commonly known as hsp70, is a protein produced in response of stress.…”

Section: Introductionmentioning

confidence: 99%

Pro-inflammatory mediators in vaginal fluid and short cervical length in pregnancy

Sisti¹,

Paccosi²,

Parenti³

et al. 2020

BLL

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AIM: We hypothesized that elevated vaginal levels of matrix metalloproteinase-8 (MMP-8), interleukin-8 (IL-8) and the 70kDa heat shock protein (hsp70), compounds involved in infl ammatory responses, correlated with a short cervix in pregnant women. METHODS: This prospective cohort study used a convenience sample of 64 women in their early third trimester with a singleton pregnancy. A short cervical length was present in 35 women (54.7 %). Vaginal fl uid was tested for levels of MMP-8, IL-8 and hsp70 by enzyme-linked immunosorbent assay (ELISA). A receiver operating charasteristic (ROC) analysis was used to calculate the area under the curve (AUC) for each mediator in predicting short cervical length. RESULTS: MMP-8 (109 vs 29.6 ng/ml, p=0.014), IL-8 (689 vs 330 pg/ml, p=0.007) and hsp70 (4.4 vs 2.9 ng/ml, p=0.036) were all elevated in vaginal samples from women with a short cervix. In addition, there was a negative association between the concentration of each compound in vaginal fl uid and cervical length p≤0.026). The vaginal IL-8 concentration had the highest negative correlation with a short cervix (AUC=0.7, p=0.007). CONCLUSION: MMP-8, hsp70 and IL-8 contribute to a pro-infl ammatory cervico-vaginal milieu that weakens cervical integrity and leads to a shortening in cervical length (Tab. 4, Fig. 1, Ref. 27).

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Short and inflamed cervix predicts spontaneous preterm birth (COLIBRI study)

Abstract: COLIBRI study used a novel, single-step method of vaginal secretions sampling during TVUS and demonstrated that combination of short cervix and IL-8 in vaginal secretions is a promising sPTB predictive test.

Cited by 14 publications

References 25 publications

Comparison of Serum and Cervical Cytokine Levels throughout Pregnancy between Preterm and Term Births

Comparison of Serum and Cervical Cytokine Levels throughout Pregnancy between Preterm and Term Births

Prediction of impending preterm delivery based on sonographic cervical length and different cytokine levels in cervicovaginal fluid in preterm labor

Pro-inflammatory mediators in vaginal fluid and short cervical length in pregnancy

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