Short and Efficient Approach Towards Macrocyclic Lactones Based on a Sonogashira Reaction.

Abstract

Short and Efficient Approach Towards Macrocyclic Lactones Based on a Sonogashira Reaction. -Title compounds (V) and (VIII) are obtained by a combination of Sonogashira and Mitsunobu reactions. The macrolactone (V) is tested against human cancer cell lines but does not show significant cytotoxic activities. -(KRAUSS*, J.; UNTERREITMEIER, D.; NEUDERT, C.; BRACHER, F.; Arch. Pharm. (Weinheim, Ger.) 338 (2005) 12, 605-608; Inst. Pharm., Zent. Pharmaforsch.,