The application of titanium alloys in weaponry is increasingly widespread, due to their high specific strength and excellent corrosion resistance. The weapons such as armors must be subjected to intense shock loads caused by explosion and hyper-velocity collision, etc., during service. Therefore, their service performance is closely related to the shock-induced response characteristics of materials, especially the microstructural evolution during the shock pulses and its effect on the mechanical properties. This chapter introduces the research progress on the shock response of some typical titanium alloys such as Ti-6Al-4V, Ti-10V-2Fe-3Al, and Ti-3.5Al-10Mo-8V-1Fe. The effects of alloying composition (alloy type) and stress amplitude on the shock-induced mechanical response and microstructural evolution of titanium alloys are explored through soft recovery shock experiments, quasi-static reloading tests, as well as careful multi-scale microscopic analyses.