Shock-induced aggression in mice is modified by lithium

Kovacsics, Colleen E.; Gould, Todd D.

doi:10.1016/j.pbb.2009.09.020

Cited by 33 publications

(28 citation statements)

References 53 publications

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“…However, treatment with lithium can reduce resident aggression in both rats and mice (O’Donnell and Gould, 2007) suggesting that the aggressive nature of the resident may in some way model the aggressive behavior seen often in human mania (Table 1,2). Lithium administration has also consistently reduced aggression induced by mild electric foot shock in rats and mice, as well as attenuate combative behaviour augmented by stimulants such as D-amphetamine (Eichelman et al, 1973, Mukherjee and Pradhan, 1976, Prasad and Sheard, 1982, Kovacsics and Gould, 2010). However, lithium also decreases the response to shock in the jump-flinch test which could confound the interpretation of lithium’s effects on shock-mediated aggression paradigms (Kovacsics and Gould, 2010).…”

Section: Environmental Models Of Maniamentioning

confidence: 99%

Animal models of bipolar mania: The past, present and future

2016

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Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the World Health Organization and affects nearly 6 million (~2.5% of the population) adults in the United State alone each year. BD is primarily characterized by mood cycling of depressive (e.g., helplessness, reduced energy and activity, and anhedonia) and manic (e.g., increased energy and hyperactivity, reduced need for sleep, impulsivity, reduced anxiety and depression), episodes. The following review describes several animal models of bipolar mania with a focus on more recent findings using genetically modified mice, including several with the potential of investigating the mechanisms underlying ‘mood’ cycling (or behavioral switching in rodents). We discuss whether each of these models satisfy criteria of validity (i.e., face, predictive, and construct), while highlighting their strengths and limitations. Animal models are helping to address critical questions related to pathophysiology of bipolar mania, in an effort to more clearly define necessary targets of first-line medications, lithium and valproic acid, and to discover novel mechanisms with the hope of developing more effective therapeutics. Future studies will leverage new technologies and strategies for integrating animal and human data to reveal important insights into the etiology, pathophysiology, and treatment of BD.

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Section: Environmental Models Of Maniamentioning

confidence: 99%

Animal models of bipolar mania: The past, present and future

2016

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“…A number of studies have found that trait impulsivity meets criteria for an endophenotype such as being heritable, associated with suicide, state independent, and co-segregated with suicidal behavior in families (Grunebaum et al, 2006;Melhem et al, 2007;Oquendo et al, 2004). Lithium may exert its antisuicidal actions by modifying impulsive, as well as impulsive, aggressive behaviors (Kovacsics et al, 2010). Some clinical evidence suggests that lithium treatment reduces impulsivity in at-risk individuals.…”

Section: Introductionmentioning

confidence: 99%

Lithium, but not Valproate, Reduces Impulsive Choice in the Delay-Discounting Task in Mice

Halcomb

Gould

Grahame

2013

Neuropsychopharmacol

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Both lithium and valproate are well-established treatments for bipolar disorder. Studies have also found that lithium is effective at reducing suicidal behaviors in patients with mood disorders. Impulsivity is a validated endophenotype of both bipolar disorder and suicidal behavior. We assessed effects of treatment with lithium or valproate on cognitive impulsivity in selectively bred mice previously shown to manifest relatively high levels of cognitive impulsivity. Mice were trained in the delay-discounting paradigm, a measure of cognitive impulsivity reflecting a behavioral bias towards immediacy, and then treated with lithium, valproate, or control chow. After 3 weeks of drug treatment, mice were tested at various delays to a large, delayed reward. Drug treatment continued during this time. Lithium reduced impulsivity, whereas valproate had no effect on choice behavior. Both drugs increased the number of choice trials and reinforcer intake, but effects on choice behavior did not depend on these motivational changes. To our knowledge, this is the first study demonstrating lithium's effects to reduce cognitive impulsivity. Future studies may focus on the ability of putative pharmacotherapies for patients at risk for bipolar disorder or suicide to modify the impulsive choice dimension of this diseases.

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“…That work was subsequently extended to look at the gene expression changes in blood from the animals on the different treatments, as a way of identifying brain-blood biomarkers [Le-Niculescu et al, 2009b]. Niculescu et al, 2008Niculescu et al, , 2011b Nile grass rat [Ashkenazy-Frolinger et al, 2010] Methamphetamine [Niculescu et al, 2000;Macedo et al, 2013] Learned helplessness [Mingmalairak et al, 2010] CLOCK [Roybal et al, 2007;Mukherjee et al, 2010;Arey et al, 2013] Flinders Sensitive Line (FSL) rats [Malkesman and Weller, 2009] Methamphetamine/valproate [Ogden et al, 2004] Isolation housing [Le-Niculescu et al, 2008;Niwa et al, 2013] CTNNB1 [Gould et al, 2008] Wistar Kyoto (WKY) rats [Will et al, 2003;Malkesman and Weller, 2009] Amphetamine-chlordiazepoxide [Kelly et al, 2009] Forced swim test [Le-Niculescu et al, 2008] POLG [Kasahara et al, 2006;Kubota et al, 2010] Madison (MSN) [Saul et al, 2012] Lithium [Gould et al, 2007;Johnson et al, 2009;Kovacsics and Gould, 2010] Tail suspension test [Le-Niculescu et al, 2008] HINT1 [Barbier and Wang, 2009] Other mood stabilizers: Lamotrigene [Li et al, 2010], Topiramate [Bourin et al, 2009] Restraint stress [Johnson et al, 2009;Koo et al, 2010] GRIN2A [Taniguchi et al, 2009] Ouabain [Herman et al, 2007] Shock-induced aggression …”

Section: Animal Modelsmentioning

confidence: 99%

Convergent functional genomics of psychiatric disorders

Niculescu

2013

American J of Med Genetics Pt B

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Genetic and gene expression studies, in humans and animal models of psychiatric and other medical disorders, are becoming increasingly integrated. Particularly for genomics, the convergence and integration of data across species, experimental modalities and technical platforms is providing a fit‐to‐disease way of extracting reproducible and biologically important signal, in contrast to the fit‐to‐cohort effect and limited reproducibility of human genetic analyses alone. With the advent of whole‐genome sequencing and the realization that a major portion of the non‐coding genome may contain regulatory variants, Convergent Functional Genomics (CFG) approaches are going to be essential to identify disease‐relevant signal from the tremendous polymorphic variation present in the general population. Such work in psychiatry can provide an example of how to address other genetically complex disorders, and in turn will benefit by incorporating concepts from other areas, such as cancer, cardiovascular diseases, and diabetes. © 2013 Wiley Periodicals, Inc.

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Shock-induced aggression in mice is modified by lithium

Cited by 33 publications

References 53 publications

Animal models of bipolar mania: The past, present and future

Animal models of bipolar mania: The past, present and future

Lithium, but not Valproate, Reduces Impulsive Choice in the Delay-Discounting Task in Mice

Convergent functional genomics of psychiatric disorders

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