SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients

Abstract

BackgroundSerine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Many epidemiologic studies have explored the association between C1420T polymorphism and the risk of non-Hodgkin lymphoma (NHL), but the results have been contradictory. Therefore, we performed this meta-analysis to evaluate the relationship.MethodsThe meta-analyses were conducted to evaluate the effect of SHMT1 C1420T polymorphism on NHL risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure the strength of the association.ResultsEight studies encompassing 3232 cases and 4077 controls were included. A statistically significant association was found between SHMT1 C1420T polymorphism and NHL risk under the allelic comparison (T vs. C: OR = 1.09, 95% CI 1.01–1.17); a borderline association was found between SHMT1 C1420T polymorphism and NHL risk under the homozygote model (TT vs. CC: OR = 1.18, 95% CI 1.00–1.39) and the dominant model (CT+TT vs. CC: OR = 1.10, 95% CI 1.00–1.21).ConclusionSHMT1 C1420T polymorphism may be associated with NHL risk, which needs to be validated in large, prospective studies.

Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression

“… 27 , 28 Additionally, polymorphisms in the SHMT1 gene have been shown to be associated with a wide variety of cancers, including childhood acute lymphoblastic leukemia, non-Hodgkins lymphoma, head and neck cancers, and colon cancer. 29 , 30 , 31 , 32 In this study, we identified SHMT1 as a new regulator of ovarian cancer tumor growth and progression.…”

Interaction Analysis of SHMT1/2 Gene Variants with HCC in Chinese Patients

“…Genetic variation plays an important role in HCC susceptibility and disease development (25). As the key enzymes in one-carbon metabolism, SHMT1/2 are essential for dNTP synthesis (26,27). Previous studies have shown that the expression level and activity of SHMT1/2 are closely associated with the occurrence and development of tumor.…”

Association of theMDM2SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis

“…Subgroup analysis was performed by cancer type (if one cancer type contained only one study, it would be merged into the “other” group), ethnicity, and sample size (<500 and ≥500). Sensitivity analysis was used to evaluate the effect of individual investigations on the overall cancer risk by excluding each investigation individually and recalculating the ORs and the 95% CIs [27]. All the statistical tests were performed with Stata (version 12.0; Stata Corporation, College Station, TX).…”