Ship-in-a-bottle growth of NaYF4: Yb3+/Tm3+ upconversion nanocrystals in desilicated ZSM-5 zeolite for drug release monitoring

Liao, Huazhen; Ye, Song; Ding, Jingxin; Yu, Jianzhong; Xv, Xinling; Pan, Ling; Lin, Peixuan; Wang, Deping

doi:10.1016/j.materresbull.2022.111926

Cited by 5 publications

(4 citation statements)

References 52 publications

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“…Therefore, a higher amount of doxorubicin can be released around the tumour, concentrating the drug in the specific action site and, subsequently, potentially reducing chemotherapy side effects. Recently, doxorubicin was used as a model drug for the development of a MDDs, with sustained release and real-time drug release monitoring functions in which the desilicated ZSM-5 zeolite with mesoporosity acted as drug carrier and NaYF4: Yb 3+ /Tm 3+ nanocrystals functioned as monitoring probe [ 135 ]. Following a ship-in-a bottle route, NaYF4: Yb 3+ /Tm 3+ nanocrystal was synthetized by impregnation in ZSM-5 previously desilicated and the DOX loaded inside this composite, wherein this composite made possible the release monitoring, and also has a good biocompatibility.…”

Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

Zeolites as Ingredients of Medicinal Products

et al. 2023

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Development of new medicinal products for particular therapeutic treatment or for better manipulations with better quality and less side effects are possible as a result of advanced inorganic and organic materials application, among which zeolites, due to their properties and versatility, have been gaining attention. This paper is an overview of the development in the use of zeolite materials and their composites and modifications as medicinal products for several purposes such as active agents, carriers, for topical treatments, oral formulations, anticancer, the composition of theragnostic systems, vaccines, parenteral dosage forms, tissue engineering, etc. The objective of this review is to explore the main properties of zeolites and associate them with their drug interaction, mainly addressing the advances and studies related to the use of zeolites for different types of treatments due to their zeolite characteristics such as molecule storage capacity, physical and chemical stability, cation exchange capacity, and possibility of functionalization. The use of computational tools to predict the drug—zeolite interaction is also explored. As conclusion was possible to realize the possibilities and versatility of zeolite applications as being able to act in several aspects of medicinal products.

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Section: Zeolites As Drug Delivery Systemsmentioning

confidence: 99%

Zeolites as Ingredients of Medicinal Products

et al. 2023

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“…It is estimated from the emission spectra that the heat treatment-induced enhancements in emission intensity are 4.9 and 2.2 times for NaYF 4 :Yb/Er@DSi1.0MOR and NaGdF 4 :Yb/Er@DSi1.0MOR, respectively. According to previous studies, proper thermal treatment can promote the formation of tightly combined interfaces between the nanocrystals and the host zeolite, which can effectively modify the surface defects of the nanocrystals, and thus the improved upconversion emission can be obtained [28]. However, the increase in nanocrystal size after thermal treatment can also reduce the non-radiative relaxation probability of the surface RE ions and contributes to the strong upconversion emission [14,44].…”

Section: Upconversion Propertiesmentioning

confidence: 99%

“…Thereafter, some post-treatments like desilication and dealumination have been applied to enlarge the pore size and create more mesopores to benefit the loading of various nanoparticles [24][25][26]. For example, the dealuminated Zeolite 13X was used to load CeO 2 nanoparticles to prepare composites for the effective degradation of caffeine [27] and the desilicated FAU-Y and ZSM-5 zeolites were used as target zeolites for the in situ growth of UCNCs for gallic acid detection or drug delivery monitoring [14,28]. A benefit for the flexible control of the upconversion emission spectral profile is that by selecting the luminescence center, like Tm 3+ , Ho 3+ , and Er 3+ , it is expected that the UCNC-loaded zeolites can be developed as sensitive probes for the detection of various chemicals in aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

Nanocrystals Incorporated with Mordenite Zeolite Composites with Enhanced Upconversion Emission for Cu2+ Detection

Lin,

Ye,

Pan

et al. 2024

Materials

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In this research, upconversion nanocrystals incorporated with MOR zeolite composites were synthesized using the desilicated MOR zeolite as a host for the in situ growth of NaREF4 (RE = Y, Gd) Yb/Er nanocrystals. The structure and morphology of the composites were studied with XRD, XPS, and TEM measurements, and the spectral studies indicated that the subsequent thermal treatment can effectively improve the upconversion emission intensity of Er3+. By using the NaYF4:Yb/Er@DSi1.0MOR-HT composite that holds the strongest upconversion emission, a probe of UCNC@DSiMOR/BPEI was constructed with the modification of branched poly ethylenimine for the detection of Cu2+. It was indicated that the integrated emission intensity of Er3+ shows a linear dependence with the logarithm value of the Cu2+ concentration ranging from 0.1 to 10 μM. This study offered a feasible method for the construction of UCNC@zeolite composites with enhanced upconversion emission, which may have a potential application as fluorescent probes for the detection of various metal ions by adjusting the doping luminescent center.

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“…The zeolites with low Si/Al ratio are suitable for Ag + -loading through ion-exchanged methods, such as Linda A and faujasite types, which have enough exchangeable sites for the intake of Ag + and thus benefit the formation of luminescent Ag CLs to achieve remarkable emission properties [ 25 , 26 , 27 ]. Conversely, the zeolites with high Si/Al ratio have few cation-exchange sites and are not desirable for the growth of Ag CLs but may benefit the loading of quantum dots or nanocrystals [ 28 , 29 ]. As the luminescence properties of Ag CLs strongly depend on the local crystal field of host zeolite and Ag + -loading amount-related chemical states, it is necessary to understand the interaction between the luminescence center and host zeolite.…”

Section: Introductionmentioning

confidence: 99%

Tailoring the Luminescence Properties of Silver Clusters Confined in Faujasite Zeolite through Framework Modification

Pan

et al. 2022

Materials

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Faujasite zeolites with a regular micropore and mesopore structure have been considered desirable scaffolds to stabilize luminescent silver nanoclusters (Ag CLs), while turning of the emission properties of the confined Ag CLs is still under investigation. In this study, the desilicated and dealuminated faujasite zeolites were first prepared to modify the zeolite framework and Si/Al ratio before Ag+ loading. With thermal treatment on the thereafter Ag+-exchanged zeolites, the Ag CLs formatted inside the D6r cages showed red-shifted emission in the desilicated zeolites and blue-shifted emission in the dealuminated zeolites, so that a tunable emission in the wavelength range of 482–528 nm could be obtained. Meanwhile, the full width at half maximum of the emission spectra is also closely related with framework modification, which monotonously increases with enhancing Si/Al ratio of host zeolite. The XRD, XPS, and spectral measurements indicated that the tunable luminescence properties of Ag CLs result from the controlling of local crystal field and coupling between host lattice and luminescent center. This paper proposes an effective strategy to manipulate the emission properties of Ag CLs confined inside zeolites and may benefit the applications of noble metal clusters activated phosphors in imaging and tunable emission.

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Ship-in-a-bottle growth of NaYF4: Yb3+/Tm3+ upconversion nanocrystals in desilicated ZSM-5 zeolite for drug release monitoring

Cited by 5 publications

References 52 publications

Zeolites as Ingredients of Medicinal Products

Zeolites as Ingredients of Medicinal Products

Nanocrystals Incorporated with Mordenite Zeolite Composites with Enhanced Upconversion Emission for Cu2+ Detection

Tailoring the Luminescence Properties of Silver Clusters Confined in Faujasite Zeolite through Framework Modification

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