Shikimate pathway modulates the elicitor-stimulated accumulation of fragrant 2-hydroxy-4-methoxybenzaldehyde in Hemidesmus indicus roots

Kundu, Anish; Jawali, Narendra; Mitra, Adinpunya

doi:10.1016/j.plaphy.2012.04.005

Cited by 33 publications

(14 citation statements)

References 23 publications

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“…It can be hypothesized that hydroxybenzoates, including HMB, are most likely produced through either of these two pathways or by crosstalk between the two. Studies on H. indicus indicate a sharp increase in the levels of PAL as well as shikimate dehydrogenase on elicitation [26,71], thus helping to conclude that HMB regulation is linked to these pathways.…”

Section: Resultsmentioning

confidence: 95%

“…The root extracts of H. indicus roots and Vanilla planifolia pods rich in MBALD and 4-hydroxy-3-methoxybenzaldehyde (vanillin) have been widely used as flavors for food preparation, in addition, MBALD is known to inhibit the activity of the enzyme acetylcholinesterase, hence these plant-based food flavors can be used for curing neurodegenerative disorders specially the Alzheimer's disease [26].…”

Section: H Indicusmentioning

confidence: 99%

“…The review focuses on the isomer of vanillin, 2-hydroxy-4-methoxybenzaldehyde, also called MBALD, HMB, or 2H4MB, a flavor HMB has so far been found in the essential or volatile oils on extraction from roots with various solvents including dichloromethane, methanol, petroleum ether, and ethyl acetate [26,27]. The presence of HMB in the extract has been confirmed using thin-layer chromatography, the solvent system being hexane:benzene (1:1); this technique, coupled with observation under short length ultraviolet, has facilitated in determining the presence of this hydroxybenzoate [28].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

2-Hydroxy-4-Methoxybenzaldehyde, an Astounding Food Flavoring Metabolite: A Review

Rathi¹,

Harwalkar²,

Jayashree³

et al. 2017

Asian J Pharm Clin Res

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Objective: Rich endowment of traditional knowledge plays a critical role in health care, food security, culture, environment and development. Traditional knowledge is also widely used by the aromatic, flavoring, food and health industries. Plant-based traditional medicine has often been used to identify and fast-track the development of modern food and drugs. Plants synthesize such wide array of secondary metabolites that includes alkaloids, glucosinolates, terpenoids and phenylpropanoids. This study is aimed to review on indigenous and exotic medicinal plants containing an astounding food flavoring metabolite; 2-hydroxy-4-methoxybenzaldehyde (HMB). Material and Method:The review focuses on the isomer of vanillin, 2-hydroxy-4-methoxybenzaldehyde, also called MBALD, HMB, or 2H4MB, a flavor compound that is generally found in the roots and rhizomes of medicinal plants. This food flavoring phenylpropenoid is one of the least investigated isomers of vanillin. HMB is known to exhibit a wide array of medicinal properties. Though the molecular role of these metabolites remains largely unknown, they are known to play a key role in plant-environment interactions/stress response/defence signaling and application in pharmaceutical and nutraceutical industries. Discussion and Conclusion:One of the key secondary metabolites is the group of phenylproponoids synthesized either through shikimic acid pathway or the malonate/acetate pathway. Phenylalanine ammonia lyase (PAL) is the enzyme involved in phenylpropanoid pathway catalysing the deamination of phenylalanine to synthesize cinnamic acid that subsequently synthesizes variety of phenylpropanoid products. Inspite of its medicinal importance, the regulatory molecular mechanism underlying the biosynthetic pathway is largely unknown.

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Section: Resultsmentioning

confidence: 95%

Section: H Indicusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

2-Hydroxy-4-Methoxybenzaldehyde, an Astounding Food Flavoring Metabolite: A Review

Rathi¹,

Harwalkar²,

Jayashree³

et al. 2017

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…Apart from H. indicus, Decalepis hamiltonii has also been reported to accumulate MBALD in roots as a chief chemical constituent (96%) 9,10 (Table 1). Accumulation of MBALD was found to be enhanced after chitosan and yeast extract treatment in H. indicus field roots 1,11 . Enhanced accumulation of MBALD was also found in micro-propagated Decalepis hamiltonii upon treatment with triacontanol (TRIA) 10 .…”

Section: Occurrence Of Methoxybenzaldehydes In Plantsmentioning

confidence: 96%

“…But the works reported on methoxybenzaldehyde biosynthesis do not complete the picture. Specifically, methoxybenzaldehydes, like MBALD and vanillin, which are accumulated in plants in significantly high amount, were found to be synthesized via phenylpropanoid pathway using cinnamate and hydroxycinnamate as their intermediates; although most of the enzymes involved in the pathway are not well characterized and some of them remain indeterminate 11,46 . Therefore, a proper and organized compilation of previous reports is needed for further research on elucidating methoxybenzaldehyde biosynthesis in plants.…”

Section: Biosynthesis Of Fragrant Methoxybenzaldehydesmentioning

confidence: 99%

Methoxybenzaldehydes in Plants:Insight to the Natural Resources, Isolation, Application and Biosynthesis

Kundu

Mitra

2016

Current Science

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Separation and identification of candidate protein elicitors from the cultivation medium of Leptosphaeria maculans inducing resistance in Brassica napus

Nováková

Kim

Šašek

et al. 2016

Biotechnology Progress

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The Dothideomycete Leptosphaeria maculans, a worldwide fungal pathogen of oilseed rape (Brassica napus), secretes a broad spectrum of molecules into the cultivation medium during growth in vitro. Here, candidate elicitor molecules, which induce resistance in B. napus to L. maculans, were identified in the cultivation medium. The elicitation activity was indicated by increased transcription of pathogenesis-related gene 1 (PR1) and enhanced resistance of B. napus plants to the invasion of L. maculans. The elicitation activity was significantly lowered when the cultivation medium was heated to 80°C. Active components were further characterized by specific cleavage with the proteolytic enzymes trypsin and proteinase K and with glycosidases α-amylase and β-glucanase. The elicitor activity was eliminated by proteolytic digestion while glycosidases had no effect. The filtered medium was fractionated by either ion-exchange chromatography or isoelectric focusing. Mass spectrometry analysis of the most active fractions obtained by both separation procedures revealed predominantly enzymes that can be involved in the degradation of plant cell wall polysaccharides. This is the first study searching for L. maculans-specific secreted elicitors with a potential to be used as defense-activating agents in the protection of B. napus against L. maculans in agriculture. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:918-928, 2016.

show abstract

Shikimate pathway modulates the elicitor-stimulated accumulation of fragrant 2-hydroxy-4-methoxybenzaldehyde in Hemidesmus indicus roots

Cited by 33 publications

References 23 publications

2-Hydroxy-4-Methoxybenzaldehyde, an Astounding Food Flavoring Metabolite: A Review

2-Hydroxy-4-Methoxybenzaldehyde, an Astounding Food Flavoring Metabolite: A Review

Methoxybenzaldehydes in Plants:Insight to the Natural Resources, Isolation, Application and Biosynthesis

Separation and identification of candidate protein elicitors from the cultivation medium of Leptosphaeria maculans inducing resistance in Brassica napus

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