Shiga toxin-producing Escherichia coli isolated from human and pig origin induce different gene expression profiles in human Caco-2 epithelial cells

Kennedy, C.A.; Lenahan, M.; Ryan, M. F.; Fanning, Séamus; Sheridan, J.J.; McNamara, Eleanor; Carroll, Anne; Sweeney, T.

doi:10.1016/j.livsci.2010.06.061

Cited by 1 publication

(2 citation statements)

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“…The effect of swine STEC strains on human intestinal cells Kennedy et al (2010) infected human Caco-2 cells, which is a human colonic epithelial cell line, with STEC O157:H7 strains isolated from human patients or from healthy pigs at slaughter facilities. The human and swine STEC strains possessed the same virulence gene profiles, including eae and other virulence genes, published in an earlier study (Lenahan et al, 2009b).…”

Section: Molecular Epidemiology Of Swine Stecmentioning

confidence: 99%

“…Moreover, microarray experiments that examined RNA levels transcribed from different STEC genes indicated that swine and human STEC strains had different gene expression profiles. When exposed to swine STEC strains, expression levels of some genes involved in cytoskeleton rearrangement were up-regulated in the human Caco-2 cells (Kennedy et al , 2010). However, more research is needed to further examine the effect of infection with swine STEC strains on human epithelial cells.…”

Section: The Effect Of Swine Stec Strains On Human Intestinal Cellsmentioning

confidence: 99%

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Shiga toxin-producingEscherichia coliin swine: the public health perspective

Tseng

Fratamico

Manning

et al. 2014

Anim. Health. Res. Rev.

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Shiga toxin-producing Escherichia coli (STEC) strains are food-borne pathogens that are an important public health concern. STEC infection is associated with severe clinical diseases in human beings, including hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS), which can lead to kidney failure and death. Cattle are the most important STEC reservoir. However, a number of STEC outbreaks and HUS cases have been attributed to pork products. In swine, STEC strains are known to be associated with edema disease. Nevertheless, the relationship between STEC of swine origin and human illness has yet to be determined. This review critically summarizes epidemiologic and biological studies of swine STEC. Several epidemiologic studies conducted in multiple regions of the world have demonstrated that domestic swine can carry and shed STEC. Moreover, animal studies have demonstrated that swine are susceptible to STEC O157:H7 infection and can shed the bacterium for 2 months. A limited number of molecular epidemiologic studies, however, have provided conflicting evidence regarding the relationship between swine STEC and human illness. The role that swine play in STEC transmission to people and the contribution to human disease frequency requires further evaluation.

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Section: Molecular Epidemiology Of Swine Stecmentioning

confidence: 99%

Section: The Effect Of Swine Stec Strains On Human Intestinal Cellsmentioning

confidence: 99%