2020
DOI: 10.1099/jmm.0.001215
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Shiga toxin-producing Escherichia coli haemolytic uraemic syndrome (STEC-HUS): diagnosis, surveillance and public-health management in England

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Cited by 17 publications
(15 citation statements)
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“…If food histories indicate that contaminated food is unlikely to be the vehicle, testing faecal specimens from household pets may identify the transmission vector. Most importantly, this investigation highlighted the need for more widespread use of rapid, diagnosis of STEC-HUS, and has been a driver in the move towards implementing commercial gastrointestinal PCR assays in local and regional hospital laboratories in England [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…If food histories indicate that contaminated food is unlikely to be the vehicle, testing faecal specimens from household pets may identify the transmission vector. Most importantly, this investigation highlighted the need for more widespread use of rapid, diagnosis of STEC-HUS, and has been a driver in the move towards implementing commercial gastrointestinal PCR assays in local and regional hospital laboratories in England [ 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…Clinically, the diagnosis of STEC-HUS mainly relies on prior potential infections or exposure history, corresponding clinical symptoms, and auxiliary examinations that indicate thrombotic microangiopathy, such as nonimmune hemolytic anemia (hematocrit < 30%, with fragmented erythrocytes in peripheral blood smear and a negative Coombs test), thrombocytopenia (platelet count < 150,000 mm 3 ), and abnormal renal function (a serum creatinine concentration that exceeds the upper limit of the reference range for age) with or without hypocomplementemia. If the occurrence of STEC-HUS is suspected, fecal and serological tests are required to determine whether there is evidence of a STEC infection [ 21 ] ( Figure 2 ).…”
Section: Stec-hus Diagnosismentioning
confidence: 99%
“…In England, a sub-set of laboratories, approximately 20%, use commercial PCR assays for the detection of gastrointestinal pathogens, including STEC other than serotype O157:H7 (non-O157 STEC) ( [14], Public Health England (PHE) in-house data). Faecal specimens from patients where there is a clinical suspicion of HUS and/or those testing positive for STEC by PCR and culture-negative for STEC O157:H7 on cefixime-tellurite sorbitol MacConkey agar are submitted to the Gastrointestinal Bacteria Reference Unit at PHE for confirmation by PCR and culture [15,16]. In Scotland, all faecal specimens from patients with severe gastrointestinal symptoms, specifically bloody diarrhoea and HUS, are submitted to the SERL for PCR and culture.…”
Section: Microbiology Investigationsmentioning
confidence: 99%