Shiftwork and Biomarkers of Subclinical Cardiovascular Disease

Abstract

Objective: To assess the association of shift work with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.Methods: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. Results:Associations were observed between day and night shift workers for leukocytes, tumor necrosis factor alpha and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shift workers with a BMI ≥ 30 kg/m 2 versus the day shift.Conclusions: Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shift work.

Working hours, sleep, and fatigue in the public safety sector: A scoping review of the research

“…Male officers who worked afternoon or night shifts had larger declines in endothelial function compared to officers working day shift 135 . Another study found that officers working night shift had higher levels of biomarkers for subclinical CVD (leukocytes, TNF‐α, and homocysteine) compared to officers working day shift 149 …”

“…135 Another study found that officers working night shift had higher levels of biomarkers for subclinical CVD (leukocytes, TNF-α, and homocysteine) compared to officers working day shift. 149 Few studies described mitigation strategies for chronic diseases.…”

Shift Work is Associated with an Elevated White Blood Cell Count: A Systematic Review and Meta-Analysis

“…All eligible studies were published between the periods from 2007 to 2022. Out of these, ten studies were from America,[ 15 17 21 22 23 24 25 26 27 28 ] seven were from Europe,[ 16 29 30 31 32 33 34 ] seven were from East Asia,[ 10 14 35 36 37 38 39 ] and one study was from the Middle East. [ 40 ] Most of the studies were cross-sectional, and only one used a retrospective design.…”

“…In 15 of those studies, the average age of the shift employees was lower than that of the day employees. The study population represented employees from different occupational sectors such as health care,[ 10 16 21 24 28 29 31 32 33 ] manufacturing,[ 14 25 27 36 37 38 39 ] police,[ 22 26 ] universities,[ 35 ] and the general population. [ 23 ] Total WBC counts were reported in 20 studies, while both total and differential WBC counts were reported in eight studies.…”

Μελέτη των μεταβολών των κιρκαδιανών ρυθμών της θερμοκρασίας και της μελατονίνης σε βαρέως πάσχοντες ασθενείς με σήψη και σηπτικό shock

“…Αντίστροφη ήταν η μεταβολή των επιπέδων της κορτιζόλης στην ίδια ομάδα εργαζομένων. Τέλος, η σχετιζόμενη με την εργασία σε βάρδιες διαταραχή του κιρκάδιου ρυθμού, έχει σχετισθεί με αυξημένη επίπτωση νεοπλασιών, που αποδίδεται στην απορύθμιση του ενδοκρινικού συστήματος και την πυροδότηση ορμονοεξαρτώμενων νεοπλασιών όπως του μαστού [44,47], σακχαρώδους διαβήτη τύπου ΙΙ [48], παχυσαρκίας [49] και καρδιαγγειακών νοσημάτων [50].…”