“…Treatment options for patients with relapsed and refractory MM have benefited from the development of new targeted agents and they include: (1) HSCT as patients with stable refractory disease subjected to HSCT have been shown to have an outcome comparable to those with chemosensitive disease, (2) using new therapeutic regimens that the patient has not been exposed to previously, (3) re-challenge with previously used chemotherapeutic regimens; (4) experimental therapy offered as part of a clinical trial, and (5) the use of new novel therapies such as the immunomodulatory agents, proteasome inhibitors and monoclonal antibodies either as single agents or in drug combinations [8][9][10]. Currently, three drug regimens are recommended as frontline therapy for patients with MM as they have proven to be effective and safe [4,5,11]. Examples of the triplet drug regimens are: VRD (bortezomib, lenalidomide and dexamethasone), VCD (bortezomib, cyclophosphamide and dexamethasone) and VTD [4].…”