Shifts in immunoglobulin (IgG, IgM and IgA) levels in the milk of southern elephant seals, at Potter Peninsula, King George Island, Antarctica

Márquez, María Elba Isabel; Carlini, Alejandro R; Baroni, A.; Ferrer, Patricia; Slobodianik, Nora; Godoy, María Fernanda

doi:10.1007/s00300-002-0471-y

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…2005b). According to Marquez et al . (2003) the level of G class immunoglobulins in colostrum of mares ranges from 15 to 60 g/L and influences antibody levels in blood of foals.…”

Section: Discussionmentioning

confidence: 99%

Studies of composition and major protein level in milk and colostrum of mares

Pecka¹,

Dobrzański

Zachwieja³

et al. 2011

Animal Science Journal

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The aim of the study was to determine the changes in composition and physicochemical features (pH, density, thermostability and acidity) of mare colostrum and milk, and of protein fraction contribution (serum albumin, β-casein, γ-casein, α-lactalbumin, G class immunoglobulins) depending on lactation stage. The research material was colostrum and milk samples from 12 Arabian mares. Colostrum samples were collected within 2 h after parturition and milk samples were collected twice, in the 3rd and 6th weeks of lactation. The level of basic milk components decreased significantly (only lactose content increased) as compared to colostrum. Total bacteria count and somatic cell count decreased significantly with an increase in resistance and urea level. The changes observed were connected to differentiated contribution of particular protein fractions and their relative proportions. Lower levels of γ-casein (P ≤ 0.05), β-casein, serum albumin as well as α-lactalbumin were observed in colostrum as compared to those in milk. Any relationship between lactation stage and β-casein content was observed. Serum albumin and α-lactalbumin content increased in subsequent milkings. The level of G class immunoglobulins decreased significantly and its highest level was noted in colostrum. Any significant differences between the 3rd and 6th lactation weeks were obtained.

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“…2005b). According to Marquez et al . (2003) the level of G class immunoglobulins in colostrum of mares ranges from 15 to 60 g/L and influences antibody levels in blood of foals.…”

Section: Discussionmentioning

confidence: 99%

Studies of composition and major protein level in milk and colostrum of mares

Pecka¹,

Dobrzański

Zachwieja³

et al. 2011

Animal Science Journal

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“…In contrast, mammals are ideal models to study the postnatal transmission of antibodies through the colostrum and breast milk (e.g. Marquez et al 2003). Such postnatal antibodies provide offspring with protection against diseases in humans ( Van de Perre 2003;Hanson 2007), domestic animals (reviewed in Grindstaff, Brodie & Ketterson 2003) and potentially in wild animal populations (Graham et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, mammals are ideal models to study the postnatal transmission of antibodies through the colostrum and breast milk (e.g. Marquez et al. 2003).…”

Section: Introductionmentioning

confidence: 99%

Prenatal and postnatal parental effects on immunity and growth in ‘lactating’ pigeons

et al. 2012

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Summary1. Parental effects can have profound consequences on offspring phenotype. Still, little is known about the relative influence of prenatal versus postnatal parental effects of parasite exposure of parents on offspring traits. 2. In this study, we investigated the respective role of a prenatal and a postnatal immune challenge of parent feral pigeons (Columba livia) on offspring humoral immunity, growth and survival. We used a cross-fostering design and antigen injections in biological and foster parents. Feral pigeons are particularly suitable for studying the effects of parental immune challenges because they can affect the phenotype of their young through the transmission of prenatal antibodies in the egg and postnatal antibodies in the 'crop milk', a substance produced in the crop of both parents. 3. Results show that a prenatal immune challenge of biological parents with keyhole limpet haemocyanin (KLH) antigen decreased the humoral response against KLH of nestlings injected at 14 days of age. In contrast, a postnatal immune challenge of foster parents with KLH enhanced the humoral response of 1-year-old juveniles exposed to a second KLH injection, but only when these juveniles had received their first injection at 3 days of age. 4. No effect on nestling and juvenile response to another antigen (NDV) was observed, indicating that the changes in humoral responses were specific to the KLH injected in parents. In addition to this, prenatal and postnatal parental immune challenges had an interaction effect on fledging body mass, but no effect on juvenile survival. 5. This study shows that pre-and postnatal exposure to antigens in parents has contrasted effects on offspring humoral response and growth. Moreover, it shows that the timing of an early exposure to antigens in nestlings has important effects on their specific humoral response. 6. This study thus suggests that pre-and postnatal parental effects have distinct roles in shaping the phenotype of the offspring on different time scales and calls for further investigations on the potential adaptive role of combined parental effects. Moreover, it suggests that pigeon milk has positive effects on offspring humoral immunity and thus could potentially have a similar immune role as mammalian milk.

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“…IgM is not known to be transferred across mammalian placentae from maternal circulation, but may cross into the circulation of neonates in species dependent on colostrum before the gut epithelium closes (Westrom et al, 2020). Both IgG and IgM are found in seal milk (along with the mucosa-protective IgA isotype) (Marquez et al, 2003;Lowe et al, 2017), so, while it is possible that what little of these isotypes is found in pup sera derives from colostrum or milk, it is tempting to consider merely that they are produced by the pups themselves (King et al, 1998).…”

Section: Immunoglobulins-minimal or No Maternal Antibody?mentioning

confidence: 99%

Is a Little Enough? Paucity of Immune Proteins in Serum of Precocial Neonates of a Marine Carnivoran—the Atlantic Grey Seal

et al. 2022

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Mammalian mothers usually provide their offspring with large quantities of immunoglobulins (antibodies) for circulation in blood, either trans-placentally before birth, via colostrum briefly thereafter, or, less commonly, from milk. Neonates of true, phocid seals, however, are peculiarly impoverished in serum immunoglobulins, the levels of which slowly increase but do not reach adult levels by the time of weaning. We investigated whether grey seal (Halichoerus grypus) neonates compensate through an elevation or rapid maturation in levels of serum innate immune factors, namely acute phase and complement proteins. Instead, their sera contained remarkably low levels of acute phase proteins (including C-reactive protein, haptoglobin, hemopexin, ceruloplasmin, orosomucoid), compared to their mothers, that barely increased to adult levels by weaning. For complement, there was a strong demarcation between the early activation and amplification cascade components (present at normal adult levels in pups) and the late lytic membrane attack complex and regulatory proteins (consistently at low relative levels). Phocid neonates therefore differ dramatically from land Carnivorans, such as dogs and cats, in early life immune protection. That neonatal phocids survive this apparent vulnerability to infections between birth and weaning prompts questions as to what other mechanisms protect them, and the adaptive value of their seeming vulnerability.

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Shifts in immunoglobulin (IgG, IgM and IgA) levels in the milk of southern elephant seals, at Potter Peninsula, King George Island, Antarctica

Cited by 9 publications

References 24 publications

Studies of composition and major protein level in milk and colostrum of mares

Studies of composition and major protein level in milk and colostrum of mares

Prenatal and postnatal parental effects on immunity and growth in ‘lactating’ pigeons

Is a Little Enough? Paucity of Immune Proteins in Serum of Precocial Neonates of a Marine Carnivoran—the Atlantic Grey Seal

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