Shifts in Fecal Metabolite Profiles Associated With Ramadan Fasting Among Chinese and Pakistani Individuals

Chen, Siyu; Ikram, Ali; Li, Xin; Long, Danfeng; Zhang, Ying; Long, Ruijun; Huang, Xiaodan

doi:10.3389/fnut.2022.845086

Cited by 5 publications

(7 citation statements)

References 61 publications

(62 reference statements)

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“…Chen et al 53 used liquid chromatography-mass spectrometry-based metabolomics to investigate the composition of fecal metabolites in Chinese and Pakistani individuals before and after RF. Principal component analysis showed a distinct separation of metabolite profiles among ethnic groups and between pre- and post-fasting samples.…”

Section: Resultsmentioning

confidence: 99%

Review of the Literature on Ramadan Fasting and Health in 2022

Hafidh

Khan

Shaikh

et al. 2023

Ibnosina Journal of Medicine and Biomedical Sciences

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Objectives The literature on health and disease during Ramadan fasting (RF) is widely spread in many journals making it not readily accessible to those interested in the subject. Here, we provide an overview of the research on the interplay of RF with various aspects of well-being published in 2022. Materials and Methods A narrative, nonsystematic review of the international literature from a single major medical online database, PubMed, in one calendar year (2022) was conducted. The search term “Ramadan fasting” was used to retrieve the appropriate records. The relevant literature with substantial data-based content was presented in a concise thematic account, excluding those concerned with diabetes. Results Themes that emerged from the review included the pathophysiology of metabolic changes during RF, nutritional aspects including body composition and energy metabolism, cardiovascular disease and risk factors, renal function and structure, endocrinology (mainly thyroid), neurological disorders, mental health, pregnancy and fetal life, and infections (including COVID). Some miscellaneous clinical themes were identified, such as patients' and professional perspectives. Conclusions In 2022, the medical interest in RF was again widely spread across specialties. Cardiovascular disease and risk factors attract the most interest in terms of original articles and professional guidelines. We hope with this review to present a concise summary of the scholarly work on the subject in this year.

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Section: Resultsmentioning

confidence: 99%

Review of the Literature on Ramadan Fasting and Health in 2022

Hafidh

Khan

Shaikh

et al. 2023

Ibnosina Journal of Medicine and Biomedical Sciences

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“…According to a quick, non-systematic literature search in PubMed, at least two studies have been published since. One is a study by Chen et al ( 47 ), which is continuation to the study by Ali et al ( 29 ) and focuses on analyzing fecal metabolites. The second new study is the TRF study by Khan et al ( 7 ), which was briefly referenced in the introduction and the discussion.…”

Section: Discussionmentioning

confidence: 99%

The impact of intermittent fasting on gut microbiota: a systematic review of human studies

Paukkonen,

Törrönen,

Lok

et al. 2024

Front. Nutr.

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BackgroundIntermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition and therefore have various effects on gut microbiome mediated functions in humans. Research on the effects of IF on human gut microbiome is limited. Therefore, the objective of this systematic review was to determine how different types of IF affect the human gut microbiome.MethodsA literature search was conducted for studies investigating the association of different types of IF and gut microbiota richness, alpha and beta diversity, and composition in human subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) and Web of Science (RRID:SCR_022706). A total of 1,332 studies were retrieved, of which 940 remained after removing duplicates. Ultimately, a total of 8 studies were included in the review. The included studies were randomized controlled trials, quasi-experimental studies and pilot studies implementing an IF intervention (time-restricted eating, alternate day fasting or 5:2 diet) in healthy subjects or subjects with any disease.ResultsMost studies found an association between IF and gut microbiota richness, diversity and compositional changes. There was heterogeneity in the results, and bacteria which were found to be statistically significantly affected by IF varied widely depending on the study.ConclusionThe findings in this systematic review suggest that IF influences gut microbiota. It seems possible that IF can improve richness and alpha diversity. Due to the substantial heterogeneity of the results, more research is required to validate these findings and clarify whether the compositional changes might be beneficial to human health.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42021241619.

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“…The positive effects of Ramadan fasting on gut microbiota were recently demonstrated by Chen et al (131). The authors investigated the influence of fasting during Ramadan on the gut metabolic profiles in fecal samples obtained from healthy Chinese (n = 16) and Pakistani (n = 18) subjects, using liquid chromatography-mass spectrometry-based metabolomics analysis (131).…”

Section: The Gut Microbiomementioning

confidence: 99%

“…The authors investigated the influence of fasting during Ramadan on the gut metabolic profiles in fecal samples obtained from healthy Chinese ( n = 16) and Pakistani ( n = 18) subjects, using liquid chromatography-mass spectrometry-based metabolomics analysis ( 131 ). Chen et al ( 131 ) concluded fasting leads to changes in metabolite profiles specific to each ethnic group in a manner dependent on dietary components. Additionally, these changes are correlated with dynamic shifts in microbiota composition and diversity which, in conjunction with dietary changes during Ramadan fasting, lead to the enrichment or depletion of various functional metabolites ( 131 ).…”

Section: Religious Fasting Nutrition and Individual Healthmentioning

confidence: 99%

“…Chen et al ( 131 ) concluded fasting leads to changes in metabolite profiles specific to each ethnic group in a manner dependent on dietary components. Additionally, these changes are correlated with dynamic shifts in microbiota composition and diversity which, in conjunction with dietary changes during Ramadan fasting, lead to the enrichment or depletion of various functional metabolites ( 131 ).…”

Section: Religious Fasting Nutrition and Individual Healthmentioning

confidence: 99%

See 1 more Smart Citation

Religious fasting and its impacts on individual, public, and planetary health: Fasting as a “religious health asset” for a healthier, more equitable, and sustainable society

Trabelsi

Ammar²,

Boujelbane³

et al. 2022

Front. Nutr.

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Religious fasting is practiced by people of all faiths, including Christianity, Islam, Buddhism, Jainism, as well as Hinduism, Judaism, and Taoism. Individual/clinical, public, global, and planetary health has traditionally been studied as separate entities. Nevertheless, religious fasting, in conjunction with other religious health assets, can provide several opportunities, ranging from the individual to the population, environmental, and planetary levels, by facilitating and supporting societal transformations and changes, such as the adoption of healthier, more equitable, and sustainable lifestyles, therein preserving the Earth's systems and addressing major interconnected, cascading, and compound challenges. In this review, we will summarize the most recent evidence on the effects of religious fasting, particularly Orthodox and Ramadan Islamic fasting, on human and public health. Further, we will explore the potential effects of religious fasting on tackling current environmental issues, with a special focus on nutrition/food restriction and planetary health. Finally, specific recommendations, particularly around dietary intake during the fasting rituals, will be provided to ensure a sustainable healthy planet.

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Shifts in Fecal Metabolite Profiles Associated With Ramadan Fasting Among Chinese and Pakistani Individuals

Cited by 5 publications

References 61 publications

Review of the Literature on Ramadan Fasting and Health in 2022

Review of the Literature on Ramadan Fasting and Health in 2022

The impact of intermittent fasting on gut microbiota: a systematic review of human studies

Religious fasting and its impacts on individual, public, and planetary health: Fasting as a “religious health asset” for a healthier, more equitable, and sustainable society

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