Shifting patterns of cellular energy production (adenosine triphosphate) over the day and key timings for the effect of optical manipulation

Shinhmar, Harpreet; Kam, Jaimie Hoh; Mitrofanis, John; Hogg, Chris; Jeffery, Glen

doi:10.1002/jbio.202200093

Cited by 4 publications

(4 citation statements)

References 37 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increases in ATP following 670 nm PBM in mice range from ~20% in the retina to >50% in the brain [5]. In whole flies, it is ~30% [13]. Because increased ATP production needs to be fuelled by glucose and oxygen, we established the hypothesis that 670 nm PBM may have the ability to reduce blood glucose.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Light stimulation of mitochondria reduces blood glucose levels

Powner,

Jeffery

2024

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

Mitochondria regulate metabolism, but solar light influences its rate. Photobiomodulation (PBM) with red light (670 nm) increases mitochondrial membrane potentials and adenosine triphosphate production and may increase glucose demand. Here we show, with a glucose tolerance test, that PBM of normal subjects significantly reduces blood sugar levels. A 15 min exposure to 670 nm light reduced the degree of blood glucose elevation following glucose intake by 27.7%, integrated over 2 h after the glucose challenge. Maximum glucose spiking was reduced by 7.5%. Consequently, PBM with 670 nm light can be used to reduce blood glucose spikes following meals. This intervention may reduce damaging fluctuations of blood glucose on the body.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It is also more demonstrable in regions of high metabolic activity such as the central nervous system (CNS). Consequently, ATP that has declined through ageing can be improved by $30% in whole flies [13] and 15% in mouse retina and $50% in mouse brain [5].…”

Section: Introductionmentioning

confidence: 99%

Light stimulation of mitochondria reduces blood glucose levels

Powner,

Jeffery

2024

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

show abstract

“…[29] Mitochondrial oxidation rate peaks in the morning, coincident with the known surge of blood glucose. [30] Morning is the only time widow when 670 nm exposure is effective at manipulating mitochondrial function. [6,30] Hence, a brief exposure as a part of an early daily routine could be incorporated into normal life, supporting current recommended glucose control measures.…”

Section: Discussionmentioning

confidence: 99%

Optical stimulation of mitochondria reduces blood glucose levels

Powner,

Jeffery

2023

Preprint

Self Cite

View full text Add to dashboard Cite

Mitochondria regulate metabolism, but solar light influences its rate. Red light increases mitochondrial membrane potentials and ATP production and may increase glucose demand. Here we show, with a glucose tolerance test, that red light exposure in normal subjects significantly reduces blood sugar levels. A 15 min exposure to 670 nm light, reduced the degree of blood glucose elevation following glucose intake by 27.7%, over 2 h. Maximum glucose spiking was reduced by 5.1%. Decreased blood glucose correlated with increased exhaled end-tidal CO2 partial pressure at 1 h, indicating the mechanism includes an increased oxidation rate. Consequently, 670 nm light exposure can be used to reduce blood glucose spikes following meals. This may reduce damaging fluctuations of blood glucose on the body, a major risk factor for diabetic complications, offering a safe, non-invasive intervention for glucose management of diabetes at home.

show abstract

“…Our suggestion of an arousal-dependent effect of photobiomodulation is not inconsistent with recent findings that photobiomodulation influences cell function differently depending on the time of day when it is applied, that photobiomodulation-induced cellular effects follow circadian rhythms. In a drosophila model, photobiomodulation has been reported to increase mitochondrial function and ATP (adenosine triphosphate) levels more effectively in the mornings, compared to the afternoons or at night ( Weinrich et al, 2019 ; Shinhmar et al, 2022 ). There are also indications of a similar pattern in humans, that photobiomodulation improves visual function more effectively when applied in the mornings compared to later in the day, in the afternoons ( Shinhmar et al, 2020 ).…”

Section: A Speculation: There Is An Arousal-dependent Effect Of Photo...mentioning

confidence: 99%

The effect of photobiomodulation on the brain during wakefulness and sleep

et al. 2022

Self Cite

View full text Add to dashboard Cite

Over the last seventy years or so, many previous studies have shown that photobiomodulation, the use of red to near infrared light on body tissues, can improve central and peripheral neuronal function and survival in both health and in disease. These improvements are thought to arise principally from an impact of photobiomodulation on mitochondrial and non-mitochondrial mechanisms in a range of different cell types, including neurones. This impact has downstream effects on many stimulatory and protective genes. An often-neglected feature of nearly all of these improvements is that they have been induced during the state of wakefulness. Recent studies have shown that when applied during the state of sleep, photobiomodulation can also be of benefit, but in a different way, by improving the flow of cerebrospinal fluid and the clearance of toxic waste-products from the brain. In this review, we consider the potential differential effects of photobiomodulation dependent on the state of arousal. We speculate that the effects of photobiomodulation is on different cells and systems depending on whether it is applied during wakefulness or sleep, that it may follow a circadian rhythm. We speculate further that the arousal-dependent photobiomodulation effects are mediated principally through a biophoton – ultra-weak light emission – network of communication and repair across the brain.

show abstract

Shifting patterns of cellular energy production (adenosine triphosphate) over the day and key timings for the effect of optical manipulation

Cited by 4 publications

References 37 publications

Light stimulation of mitochondria reduces blood glucose levels

Light stimulation of mitochondria reduces blood glucose levels

Optical stimulation of mitochondria reduces blood glucose levels

The effect of photobiomodulation on the brain during wakefulness and sleep

Contact Info

Product

Resources

About