2018
DOI: 10.1002/hbm.24345
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Shifted balance of dorsal versus ventral striatal communication with frontal reward and regulatory regions in cannabis‐dependent males

Abstract: The transition from voluntary to addictive behavior is characterized by a loss of regulatory control in favor of reward driven behavior. Animal models indicate that this process is neurally underpinned by a shift in ventral–dorsal striatal control of behavior; however, this shift has not been directly examined in humans. The present resting state functional magnetic resonance imaging (fMRI) study employed a two‐step approach to: (a) precisely map striatal alterations using a novel, data‐driven network classifi… Show more

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Cited by 61 publications
(57 citation statements)
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“…Accordingly, alterations in this region may reflect adaptations in incentive-based learning processes that promote exaggerated salience attributed to the drug as well as deficits in controlling impulsive behavior. The dorsal striatum, on the other hand, has been strongly associated with habit learning and the transition from reward-driven to compulsive behavior in addiction [15], [16], [142] and may promote the development of compulsive drug use in the context of progressive loss of behavioral control [143]. Together, these findings emphasize that separable neural systems may mediate specific behavioral dysregulations…”
Section: Discussionmentioning
confidence: 94%
“…Accordingly, alterations in this region may reflect adaptations in incentive-based learning processes that promote exaggerated salience attributed to the drug as well as deficits in controlling impulsive behavior. The dorsal striatum, on the other hand, has been strongly associated with habit learning and the transition from reward-driven to compulsive behavior in addiction [15], [16], [142] and may promote the development of compulsive drug use in the context of progressive loss of behavioral control [143]. Together, these findings emphasize that separable neural systems may mediate specific behavioral dysregulations…”
Section: Discussionmentioning
confidence: 94%
“…At the network level, cannabis users exhibited increased cue-induced dorsal striatal communication with prefrontal regions regardless of dependence status. Aberrant intrinsic and task-based striatal communication with frontal regions engaged in reward processing and regulatory control has been repeatedly reported in cannabis users (17,(70)(71)(72). The fronto-striatal circuits are engaged in several addiction-relevant functional domains including incentive salience processing and flexible behavioral control (1,3,36) and alterations in this circuitry may reflect exaggerated salience of drug-associated cues (71) or deficient regulatory control over behavior (17).…”
Section: Discussionmentioning
confidence: 99%
“…26 A similar approach has been employed in previous studies on stress reactivity 27 and in previous studies examining emotional processing in cannabis users. 19,20,28,29 Exclusion criteria included (1) age < 18 or > 40 years, (2) left-handedness, (3) history or current DSM-IV axis I disorders (based on MINI, exception: cannabis abuse or dependence), (4) Beck Depression Inventory (BDI-II) score > 20 30 , (5) current or history of a medical disorder including endocrinological abnormalities (6) current or regular use of medication, (7) usage of other illicit substances > 75 lifetime occasions or during the 28 days prior to the experiment, (8) positive urine screen for cocaine (300 ng/ml), methamphetamine (500 ng/ml), amphetamine (500 ng/m), methadone (300 ng/ml) or opiate (300 ng/ml) (Drug-Screen-Multi 7TF, von minden GmbH, Moers, Germany), (9) breath alcohol >0.00% (analyzed using TM-7500, Trendmedic, Penzberg, Germany). For controls, additional exclusion criteria were applied: (1) cumulative lifetime use of cannabis > 15 g (M = 1.29, SD = 1.02), (2) use of any other illicit substance >10 lifetime occasions.…”
Section: Methodsmentioning
confidence: 99%
“…38 As a trade-off, subjects were allowed to smoke as usual, however underwent a 1.5h supervised abstinence period before the start of the experimental paradigm. 20,29 Following initial quality assessments 6 cannabis users and 5 controls were excluded (supplemental materials, Figure S1), the final dataset included n = 28 dependent cannabis users and n = 23 healthy controls.…”
Section: Methodsmentioning
confidence: 99%