Shift work-like patterns effect on female and male mouse behavior

Banks, Gareth; Nolan, Patrick M.; Bourbia, Nora

doi:10.1016/j.nbscr.2022.100082

Cited by 4 publications

(6 citation statements)

References 38 publications

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“…Prior studies have reported conflicting effects of non-standard LD conditions on locomotion, with both increases and decreases observed in male rodents (Bartoszewicz et al, 2009; Delorme et al, 2022; Okuliarova et al, 2016). In female mice, both forward and inverted (shift work-like) photoperiod shifts were found to decrease locomotion (Banks et al, 2022). Notably, the reported changes in locomotor activity were not associated with any significant alterations in alcohol-drinking behavior under experimental LD conditions (Gamsby & Gulick, 2015; Rosenwasser et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…However, despite a significant decline in daily activity and consolidated rest-activity patterns, rhythm fragmentation remained unchanged irrespective of photoperiod and fluid conditions. The reduced rhythmicity resulted from impaired day-to-day coordination, evidenced by decreased interdaily stability (IS) and dampened robustness of activity rhythms (RA), rather than a fragmentation within each day (unchanged intradaily variability, IV) (Banks et al, 2022).…”

Section: Circadian Rhythmicity and Locomotor Activitymentioning

confidence: 99%

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Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats

Meyer,

Schoettner,

Amir

2024

Preprint

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Circadian dysfunction caused by exposure to aberrant light-dark conditions is associated with abnormal alcohol consumption in humans and animal models. Changes in drinking behavior have been linked to alterations in clock gene expression in reward-related brain areas, which could be attributed to either the effect of chronodisruption or alcohol. To date, however, the combinatory effect of circadian disruption and alcohol on brain functions is less understood. Moreover, despite known sex differences in alcohol drinking behavior, most research has been carried out on male subjects only, and therefore implications for females remain unclear.To address this gap, adult female rats housed under an 11h/11h light-dark cycle (LD22) or standard light conditions (LD24, 12h/ 12h light-dark) were given access to an intermittent alcohol drinking protocol (IA20%) to assess the impact on gene expression in brain areas implicated in alcohol consumption and reward: the prefrontal cortex (PFC), nucleus accumbens (NAc), and dorsal striatum (DS). mRNA expression of core clock genes (Bmal1,Clock,Per2), sex hormone receptors (ERβ,PR), glutamate receptors (mGluR5,GluN2B), a calcium-activated channel (Kcnn2), and an inflammatory cytokine (TNF-α) were measured at two-time points relative to the locomotor activity cycle.Housing under LD22 did not affect alcohol intake but significantly disrupted circadian activity rhythms and reduced locomotion. Significant changes in the expression ofBmal1,ERβ, andTNF-αwere primarily related to the aberrant light conditions, whereas changes inPer2andPRexpression were associated with the effect of alcohol. Collectively, these results indicate that disruption of circadian rhythms and/or intermittent alcohol exposure have distinct effects on gene expression in the female brain, which may have implications for the regulation of alcohol drinking, addiction, and, ultimately, brain health.

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Section: Discussionmentioning

confidence: 99%

Section: Circadian Rhythmicity and Locomotor Activitymentioning

confidence: 99%

Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats

Meyer,

Schoettner,

Amir

2024

Preprint

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“…Wild-type male C57BL/6 mice were purchased from the National Laboratory Animal Center, National Applied Research Laboratories, Taiwan. Mice were housed in a temperature (22-26 °C)- and humidity (40-60%)-controlled room with a 12 hours light/12 hours dark cycle ( Banks et al., 2022 ). Food and water were supplied ad libitum accessing to normal chow.…”

Section: Methodsmentioning

confidence: 99%

“…All animal protocols were approved by the Institutional Animal Care and Use Committee of the National Health Research Institutes accredited by the AAALAC International (Protocol No: NHRI-IACUC-104125AE). Previous studies have showed that circadian of mice could be easily regulated (Opperhuizen et al, 2015;Capri et al, 2019;Banks et al, 2022). C57BL/6 mice being with normal melanin and hair were the suitable animal model for circadian rhythms study.…”

Section: Animalsmentioning

confidence: 99%

Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation

Huang,

Yu,

et al. 2024

Front. Cell. Infect. Microbiol.

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Night shift workers have been associated with circadian dysregulation and metabolic disorders, which are tightly coevolved with gut microbiota. The chronic impacts of light-emitting diode (LED) lighting at night on gut microbiota and serum lipids were investigated. Male C57BL/6 mice were exposed to blue or white LED lighting at Zeitgeber time 13.5-14 (ZT; ZT0 is the onset of “lights on” and ZT12 is the “lights off” onset under 12-hour light, 12-hour dark schedule). After 33 weeks, only the high irradiance (7.2 J/cm2) of blue LED light reduced the alpha diversity of gut microbiota. The high irradiance of white LED light and the low irradiance (3.6 J/cm2) of both lights did not change microbial alpha diversity. However, the low irradiance, but not the high one, of both blue and white LED illuminations significantly increased serum total cholesterol (TCHO), but not triglyceride (TG). There was no significant difference of microbial abundance between two lights. The ratio of beneficial to harmful bacteria decreased at a low irradiance but increased at a high irradiance of blue light. Notably, this ratio was negatively correlated with serum TCHO but positively correlated with bile acid biosynthesis pathway. Therefore, chronic blue LED lighting at a high irradiance may harvest gut dysbiosis in association with decreased alpha diversity and the ratio of beneficial to harmful bacteria to specifically dysregulates TCHO metabolism in mice. Night shift workers are recommended to be avoid of blue LED lighting for a long and lasting time.

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“…One such example of chronic circadian disruption occurs in shift work, which puts individuals at a higher risk for cardiovascular disease, diabetes, affective disorders, obesity, fertility issues, cancer, and more ( Costa, 2010 ). Rodents that underwent a paradigm mimicking human shift work also showed many of these same negative and persistent effects ( Marti et al, 2020 ; Banks et al, 2022 ).…”

Section: Acute and Chronic Effects Of Disruptions In Sleep And Circad...mentioning

confidence: 98%

Long-lasting effects of disturbing the circadian rhythm or sleep in adolescence

Pifer,

Ferrara,

Kwapis

2024

Brain Research Bulletin

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Shift work-like patterns effect on female and male mouse behavior

Cited by 4 publications

References 38 publications

Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats

Effects of chronodisruption and alcohol consumption on gene expression in reward-related brain areas in female rats

Chronic blue light-emitting diode exposure harvests gut dysbiosis related to cholesterol dysregulation

Long-lasting effects of disturbing the circadian rhythm or sleep in adolescence

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