Shift work and the risk of cardiovascular disease. A systematic review and meta-analysis including
                    dose–response relationship

Torquati, Luciana; Mielke, Grégore Iven; Brown, Wendy J.; Kolbe-Alexander, Tracy

doi:10.5271/sjweh.3700

Cited by 343 publications

(292 citation statements)

References 44 publications

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“…These working schedules result in a misalignment between the sleep-wake cycle and the internal biological clock, which is under control of the suprachiasmatic nucleus (SCN) in the hypothalamus, also referred to as the central "master" clock. [6][7][8] In addition, shift work has been associated with a low bone mineral density and increased fracture risk, 9,10 which are both hallmarks of the bone disease osteoporosis. These tissue rhythms are driven by circadian clock genes, which promote rhythmic expression of many important tissue-specific genes and proteins.…”

Section: Introductionmentioning

confidence: 99%

Circadian disruption by shifting the light‐dark cycle negatively affects bone health in mice

et al. 2019

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The past decade, it has become evident that circadian rhythms within metabolically active tissues are very important for physical health. However, although shift work has also been associated with an increased risk of fractures, circadian rhythmicityhas not yet been extensively studied in bone. Here, we investigated which genes are rhythmically expressed in bone, and whether circadian disruption by shifts in lightdark cycle affects bone turnover and structure in mice. Our results demonstrate diurnal expression patterns of clock genes (Rev-erbα, Bmal1, Per1, Per2, Cry1, Clock), as well as genes involved in osteoclastogenesis, osteoclast proliferation and function (Rankl, Opg, Ctsk), and osteocyte function (c-Fos) in bone. Weekly alternating lightdark cycles disrupted rhythmic clock gene expression in bone and caused a reduction in plasma levels of procollagen type 1 amino-terminal propeptide (P1NP) and tartrate-resistant acidic phosphatase (TRAP), suggestive of a reduced bone turnover.These effects coincided with an altered trabecular bone structure and increased cortical mineralization after 15 weeks of light-dark cycles, which may negatively affect

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Section: Introductionmentioning

confidence: 99%

Circadian disruption by shifting the light‐dark cycle negatively affects bone health in mice

et al. 2019

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“…Indeed Jorgensen et al found an increased risk of mortality due to cardiovascular disease and diabetes, but not mortality due to cancer or psychiatric diseases (Jorgensen et al 2017). Furthermore, night work has been associated increased risk of cardiovascular disease, breast and prostate cancer, diabetes, and gastrointestinal disorders (Hansen et al 2016; Kivimaki et al 2011; Knutsson and Boggild 2010; Torquati et al 2018; Vyas et al 2012) Thus, our findings do not imply that the current guidelines for organisation of night work (see e.g. Bonde et al 2012).…”

Section: Discussionmentioning

confidence: 56%

Night-time work and all-cause mortality in the general working population of Denmark

Hannerz

Soll-Johanning

Larsen

et al. 2018

Int Arch Occup Environ Health

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PurposeA recent study among female nurses in Denmark found an increased mortality among night-time workers, which has raised concerns about the sufficiency of the EU Working Time Directive. The aim of the present study was to examine the relationship between night-time work and all-cause mortality among full-time employees in the general workforce of Denmark.MethodsInterview data from the Danish Labour Force Surveys, 1999–2013, were linked to national registers with individual-level data on occupation, industry, socioeconomic status (SES), emigrations and deaths. The participants (N = 159,933) were followed from the end of the calendar year of the interview until the end of 2014. Poisson regression was used to estimate rate ratios for all-cause mortality, with and without stratification by sex and socioeconomic status. A likelihood ratio test was used to test the overall null-hypothesis, which stated that the mortality rates were independent of night-time work, SES × night-time work and sex × night-time work.ResultsThe likelihood ratio test did not reject the null hypothesis (p = 0.14). The rate ratio for all-cause mortality among employees with vs. without night-time work was estimated at 1.07 (95% CI 0.97–1.19) after adjustment for age, sex, SES, calendar time, weekly working hours and time passed since the start of follow-up.ConclusionsThe present study did not find any statistically significant associations between night-time work and all-cause mortality among employees in the general workforce of Denmark.

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“…In conclusion, the present review of Torquati et al (3) shows that even if the number of new publications on shift work and cardiovascular health increases, many of the new studies still include the well-known old sources of bias. Some light is seen in the acknowledgement of the need for better exposure assessment of shift work.…”

Section: Confounding and Effect Mediatorsmentioning

confidence: 99%

“…In this issue, a new systematic review and meta-analysis on shift work and the risk of CVD is published. Based on 21 studies, including 10 new ones since the publication of Vyas et al (4), Torquati and colleagues (3) found that shift work was associated with coronary heart disease (CHD) morbidity with a pooled risk ratio of 1.26 (95% CI 1.10-1.43) and about 20% increased risk of death from CHD or CVD. The study also reports that risk of CVD events increased by 7.1% for every five years of exposure.…”

Section: Shift Work and Cardiovascular Disease -Do The New Studies Admentioning

confidence: 99%

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Shift work and cardiovascular disease – do the new studies add to our knowledge?

Härmä

Gustavsson²,

Kolstad³

2018

Scand J Work Environ Health

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Shift work and the risk of cardiovascular disease. A systematic review and meta-analysis including dose–response relationship

Cited by 343 publications

References 44 publications

Circadian disruption by shifting the light‐dark cycle negatively affects bone health in mice

Circadian disruption by shifting the light‐dark cycle negatively affects bone health in mice

Night-time work and all-cause mortality in the general working population of Denmark

Shift work and cardiovascular disease – do the new studies add to our knowledge?

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