Shift work and cognitive aging: a longitudinal study

Bokenberger, Kathleen; Ström, Peter; Aslan, Anna K. Dahl; Åkerstedt, Torbjörn; Pedersen, Nancy L.

doi:10.5271/sjweh.3638

Cited by 28 publications

(38 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our finding of no significant association between shift work and dementia is partly in line with previous research. In the Nurses' Health Study, Devore et al (22) found no substantial longitudinal association between night work and cognition and, in a recent study, Bokenberger et al (23) found no longitudinal association between shift work and cognitive aging. In contrast, using cross-sectional data from the VISAT study, Roach et al found indications of lower cognitive efficiency, in terms of immediate free recall, with increasing duration of shift work among males but not among females (20).…”

Section: Comparison With Previous Findingsmentioning

confidence: 97%

“…Two previous studies based on data from the VIASAT cohort found indications of lower cognitive function among shift workers (20,21), whereas two other studies found no association between shift work and cognitive function (22,23). With dementia as the outcome, one study did not find an association with history of shift work (24), whereas one recent study reported that shift work was associated with mortality due to dementia (25).…”

mentioning

confidence: 96%

See 1 more Smart Citation

Shift work, long working hours, and later risk of dementia: A long-term follow-up of the Copenhagen Male Study

Nabe‐Nielsen¹,

Garde²,

Ishtiak‐Ahmed³

et al. 2017

Scand J Work Environ Health

View full text Add to dashboard Cite

Objectives The aim of this study was to investigate the effect of shift work and long working hours in midlife on the risk of dementia in old age. Methods The present study comprised 4766 participants from the Copenhagen Male Study. We used information on shift work (collected in 1970-1971 and 1985-1986), long working hours defined as >45 hours per week (collected in 1970-1971), socioeconomic status, sleep, stress, and cardiovascular risk factors. Information about dementia diagnoses was obtained from registers. Participants were followed until 2014 (mean length of follow-up was 17.8 years). We employed Poisson regression for the survival analyses and estimated incidence rate ratios (IRR) and their 95% confidence intervals (CI). Results We found no statistically significant association between shift work (IRR 0.86, 95% CI 0.70-1.05) or long working hours (IRR 0.97, 95% CI 0.79-1.19) and dementia. Adjustment for potential confounders and mediators did not change the estimates. Working shifts at both time points of exposure assessment was not associated with a higher incidence of dementia compared with non-shift workers at both time points (IRR 0.99, 95% CI 0.69-1.42). The lowest incidence of dementia was observed among participants who reported shift work at one time point (only in 1985-1986: IRR 0.44, 95% CI 0.16-1.23 and only in 1970-1971: IRR 0.58, 95% CI 0.31-1.11). Conclusion We did not find positive evidence of an association between shift work or long working hours and the incidence of dementia, but the negative findings may reflect the crude assessment of shift work and long working hours, which is a major limitation of the present study.

show abstract

Section: Comparison With Previous Findingsmentioning

confidence: 97%

mentioning

confidence: 96%

Shift work, long working hours, and later risk of dementia: A long-term follow-up of the Copenhagen Male Study

Nabe‐Nielsen¹,

Garde²,

Ishtiak‐Ahmed³

et al. 2017

Scand J Work Environ Health

View full text Add to dashboard Cite

show abstract

“…There is evidence of transient cognitive decline in shift workers [ 9 , 10 ], as well as association with the risk of Alzheimer’s disease [ 11 ] and dementia [ 12 ]. No association with the risk of dementia or accelerated cognitive decline at later life was visible in the recent longitudinal studies [ 13 , 14 ]. However, cardiovascular death as a competing risk is likely to mask potential associations with dementia, because shift workers have increased risk for cardiovascular mortality [ 11 ] and, thus, less likely to become old enough to have dementia, like demonstrated for smoking and dementia [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age

Sulkava

Muggalla

Sulkava

et al. 2018

Sleep

View full text Add to dashboard Cite

Disruption of the circadian rhythms is a frequent preclinical and clinical manifestation of Alzheimer’s disease. Furthermore, it has been suggested that shift work is a risk factor for Alzheimer’s disease. Previously, we have reported association of intolerance to shift work (job-related exhaustion in shift workers) with a variant rs12506228A, which is situated close to melatonin receptor type 1A gene (MTNR1A) and linked to MTNR1A brain expression levels. Here, we studied association of that variant with clinical and neuropathological Alzheimer’s disease in a Finnish whole-population cohort Vantaa 85+ (n = 512, participants over 85 years) and two follow-up cohorts. Rs12506228A was associated with clinical Alzheimer’s disease (p = 0.000073). Analysis of post-mortem brain tissues showed association with higher amount of neurofibrillary tangles (p = 0.0039) and amyloid beta plaques (p = 0.0041). We then followed up the associations in two independent replication samples. Replication for the association with clinical Alzheimer’s disease was detected in Kuopio 75+ (p = 0.012, n = 574), but not in the younger case-control sample (n = 651 + 669). While melatonin has been established in regulation of circadian rhythms, an independent role has been also shown for neuroprotection and specifically for anti-amyloidogenic effects. Indeed, in vitro, RNAi mediated silencing of MTNR1A increased the amyloidogenic processing of amyloid precursor protein (APP) in neurons, whereas overexpression decreased it. Our findings suggest variation close to MTNR1A as a shared genetic risk factor for intolerance to shift work and Alzheimer’s disease in old age. The genetic associations are likely to be mediated by differences in MTNR1A expression, which, in turn, modulate APP metabolism.

show abstract

“…Por consiguiente, el trabajo a turnos proporciona complicaciones a los ritmos circadianos afectando todo esto al rendimiento cognitivo del individuo (Bokenberger, Ström, Dahl, Åkerstedt, y Pedersen, 2017).…”

Section: Discussionunclassified

Rol del Psicólogo Organizacional en la gestión de Talento Humano

Silva¹,

Marín²,

Baldeón³

2018

Podium

View full text Add to dashboard Cite

INFORMACIÓN DEL ARTÍCULO ResumenEste artículo tiene por objeto describir el rol profesional del Psicólogo Organizacional en la gestión del Talento Humano. La información se obtuvo mediante un proceso de revisión bibliográfica que hace referencia al surgimiento de la Psicología, y posteriormente al desarrollo de la Psicología Organizacional, especialmente en la gestión del Talento Humano. El desarrollo del artículo se alinea a un enfoque sistémico del área de Talento Humano y de los subsistemas que habitualmente lo caracterizan. Adicionalmente, se muestra como conclusión una postura argumentativa de la función que realiza el Psicólogo Organizacional en varios subsistemas de Talento Humano, alineado a la estrategia organizacional, logrando la misión y el alcance de la visión. Palabras Clave:Psicología, Rol, Organización, Psicología Organizacional, Talento Humano.Clasificación JEL: D23, J24, O15. AbstractThe purpose of this article is to describe the professional role of the Organizational Psychologist in the management of Human Talent. The information was obtained through a bibliographic review process that refers to the emergence of Psychology, and later to the development of Organizational Psychology, especially in the management of Human Talent. The development of the article is aligned to a systemic approach of the Human Talent area and the subsystems that usually characterize it. Additionally, an argumentative view of the function performed by the Organizational Psychologist in several Human Talent subsystems, aligned with the organizational strategy, achieving the mission and scope of the vision, is shown as a conclusion.

show abstract

Shift work and cognitive aging: a longitudinal study

Cited by 28 publications

References 27 publications

Shift work, long working hours, and later risk of dementia: A long-term follow-up of the Copenhagen Male Study

Shift work, long working hours, and later risk of dementia: A long-term follow-up of the Copenhagen Male Study

Melatonin receptor type 1A gene linked to Alzheimer’s disease in old age

Rol del Psicólogo Organizacional en la gestión de Talento Humano

Contact Info

Product

Resources

About