Shift work and age as interactive predictors of body mass index among offshore workers

Parkes, Katharine R.

doi:10.5271/sjweh.648

Cited by 152 publications

(126 citation statements)

References 45 publications

(56 reference statements)

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“…14,27 Our results are consistent with previous studies showing that the prevalence of obesity is higher in shift workers 15 and that weight gain occurs in late-shift workers (evening and night), 16 cleanroom workers changing from an 8 to a 12-h shift, 17 and offshore workers under continued exposure to day-night shift work. 18 Other evidence highlights a positive relationship between BMI and duration of shift work exposure. 19 In particular, employees involved in shift working for more than 5 y had significantly higher BMI than those with no shift work experience.…”

Section: Shift Work and Body Fatness L Di Lorenzo Et Almentioning

confidence: 99%

“…[16][17][18][19] Moreover, abdominal fat accumulation is a cardiovascular risk factor stronger than obesity itself, 14 and it is noteworthy that shift workers have been shown to have higher waist-to-hip ratio (WHR) (ie more central fat) than day workers, independently of body mass index (BMI). 20 Among several well known cardiovascular risk factors, total cholesterol [20][21][22] and triglycerides 5,21,23,24 have been shown to be higher in shift workers than in day workers, independently of other lifestyle factors.…”

Section: Introductionmentioning

confidence: 99%

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Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

et al. 2003

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OBJECTIVE:To examine the influence of shift work on metabolic and cardiovascular risk factors in subjects working in an industry sited in Apulia, Southern Italy. DESIGN: Cross-sectional study of metabolic effects of shift work in glucose tolerant workers in a chemical industry in southern Italy. SUBJECTS: The subjects included 319 glucose tolerant male individuals, aged 35-60 y. MEASUREMENTS: Anthropometric parameters (body mass index (BMI) and waist-to-hip ratio (WHR)), fasting concentrations of glucose, insulin, and lipids (total cholesterol, HDL-cholesterol, triglycerides), the sum of glucose levels during 75 g-oral glucose tolerance test (S-OGTT), and systolic and diastolic blood pressure (SBP and DBP, respectively). RESULTS: The prevalence of obesity was higher among shift workers compared to day workers, whereas body fat distribution was not different between the two groups. Shift workers had higher BMI than day workers, and shift working was associated with BMI, independently of age and work duration. Shift workers had significantly higher SBP levels, which were independently influenced by BMI, but not by shift work, thus suggesting that the difference in SBP may well be mediated by the increased body fatness. CONCLUSION: In workers of an industry sited in Southern Italy, shift work may be directly responsible for increased body fatness and is indirectly associated with higher blood pressure levels and some features of metabolic syndrome.

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Section: Shift Work and Body Fatness L Di Lorenzo Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

et al. 2003

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“…Integral to the modern lifestyle is the ability to eat, sleep, work, exercise, and socialize around the clock and yet these allowances may serve as a preamble to obesity and other metabolic disorders. Recent studies reveal that a distorted circadian cycle can lead to aberrations in metabolism, producing symptoms such as obesity, insulin resistance, and others consistent with the metabolic syndrome (5)(6)(7)(8)(9). Whereas studies focused on night-shift and rotating shift workers emphasize the link between circadian rhythmicity and metabolism, rodent models of circadian arrhythmia also support this link (10)(11)(12)(13).…”

mentioning

confidence: 99%

Coordination of the transcriptome and metabolome by the circadian clock

Eckel‐Mahan

Patel

Mohney

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

354

297

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The circadian clock governs a large array of physiological functions through the transcriptional control of a significant fraction of the genome. Disruption of the clock leads to metabolic disorders, including obesity and diabetes. As food is a potent zeitgeber (ZT) for peripheral clocks, metabolites are implicated as cellular transducers of circadian time for tissues such as the liver. From a comprehensive dataset of over 500 metabolites identified by mass spectrometry, we reveal the coordinate clock-controlled oscillation of many metabolites, including those within the amino acid and carbohydrate metabolic pathways as well as the lipid, nucleotide, and xenobiotic metabolic pathways. Using computational modeling, we present evidence of synergistic nodes between the circadian transcriptome and specific metabolic pathways. Validation of these nodes reveals that diverse metabolic pathways, including the uracil salvage pathway, oscillate in a circadian fashion and in a CLOCK-dependent manner. This integrated map illustrates the coherence within the circadian metabolome, transcriptome, and proteome and how these are connected through specific nodes that operate in concert to achieve metabolic homeostasis.C ircadian rhythms exist within a wide range of biological processes and control numerous aspects of physiology, including the sleep/wake cycle, eating, hormone and neurotransmitter secretion, and even cognitive function (1-4). Integral to the modern lifestyle is the ability to eat, sleep, work, exercise, and socialize around the clock and yet these allowances may serve as a preamble to obesity and other metabolic disorders. Recent studies reveal that a distorted circadian cycle can lead to aberrations in metabolism, producing symptoms such as obesity, insulin resistance, and others consistent with the metabolic syndrome (5-9). Whereas studies focused on night-shift and rotating shift workers emphasize the link between circadian rhythmicity and metabolism, rodent models of circadian arrhythmia also support this link (10-13). As an essential modulator of metabolism in vivo, the liver provides a cardinal domain in which to study interactions between the clock and metabolism as much of the liver transcriptome and proteome oscillates in expression or activity. These circadian characteristics of the liver are dependent largely on the zeitgeber (ZT), food (14-21).Precision within the circadian clock depends on nuclear transcriptional and translational feedback loops, but recent evidence that circadian, nontranscriptional, and nontranslational cytosolic rhythms crosstalk with nuclear rhythms to maintain circadian timing provides support for the idea that metabolites may affect the transcriptional-translational canonical clock system and vice versa (22,23). Some biochemical oscillations have been shown to cycle in a circadian fashion, such as calcium, 3′-5′-cyclic adenosine monophosphate (cAMP) and nicotinamide (NAD + ) (24-27). These oscillations feed into the clock system and can modulate circadian dynamics in vivo. Sever...

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“…On the day of killing, the body weight of the animals in all the four rat groups that were exercised was still significantly lower than that of the LS rats but not lower than that of the LC rats. The ratio of organ weight to body weight showed significant group effects in the testes (F [5,36] kidneys and lungs of the animals in all the four rat groups that were exercised tended to be higher than that of the animals in the two sedentary rat groups. However, in comparison with the animals in the other five rat groups, the weight of the adrenal glands was higher only in the LSWF rats.…”

Section: Repeated Shifts Of Exercise And/or Lighting Schedulesmentioning

confidence: 89%

“…These disturbances include high body weight gain, 1 body mass index, [2][3][4][5][6][7] waist-to-hip ratio, [6][7][8] prevalence of overweight 9 and obesity, 2,10 serum cholesterol, 8,10 and prevalence of high serum triglyceride and low high-density lipoprotein (HDL)-cholesterol. 10 However, the causal relationship between work shifts and metabolic disturbances has been questioned.…”

Section: Introductionmentioning

confidence: 99%

The effect of scheduled forced wheel activity on body weight in male F344 rats undergoing chronic circadian desynchronization

Tsai

2007

Int J Obes

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Objective: To examine whether scheduled forced wheel activity counteracts the increased body weight gain in rats undergoing chronic circadian desynchronization induced by repeated 12-h shifts in the light-dark cycle. Design: Four age-and body weight-matched groups of adult male F344 rats were subjected to 12-h intermittent forced wheel activity daily (2.2 km/day). Each group had the following schedule for 13 weeks: a fixed schedule of a daily 12:12-h light-dark cycle and activity training (WF); a fixed light-dark cycle and 12-h shifts twice a week in activity training (WS); 12-h shifts twice a week in the light-dark cycle and a fixed schedule of activity training (LSWF); and 12-h shifts twice a week in both the light-dark cycle and activity training (LSWS). Two additional age-and body weight-matched sedentary rat groups were selected from our database: one was maintained on a fixed light-dark cycle (LC) and the other was subjected to 12-h shifts twice a week in the light-dark cycle (LS). Results: The four rat groups that were exercised showed different response patterns of the daily body temperature rhythm to different combinations of forced activity and lighting schedules. Their food intake was more than that of the two sedentary rat groups, but their body weight was comparable with that of the LC rats and less than that of the LS rats during the forced activity period. The LSWS rats were heavier than the WF and WS rats in the first and second months of the experimental treatment, but their body weight was comparable with that of the WS and WF rats in the third month. Conclusion: Forced activity was effective in reducing the body weight gain in chronic circadian desynchronization that was induced by repeated shifts in the light-dark cycle, although such an effect might become significant only after some time.

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Shift work and age as interactive predictors of body mass index among offshore workers

Cited by 152 publications

References 45 publications

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

Effect of shift work on body mass index: results of a study performed in 319 glucose-tolerant men working in a Southern Italian industry

Coordination of the transcriptome and metabolome by the circadian clock

The effect of scheduled forced wheel activity on body weight in male F344 rats undergoing chronic circadian desynchronization

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