SHH Expression Is Significantly Associated With Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma

Cierpikowski, Piotr; Lis-Nawara, Anna; Bär, Julia

doi:10.21873/anticanres.15352

Cited by 7 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, up to now, no specific biomarker of CSC has allowed for the isolation of a pure CSC population from HNSCC, what confirms the fact that the population of CSCs is very heterogeneous [ 7 , 73 , 78 , 79 ]. As presented in Figure 3 , HNSCC tissue shows expression of different markers that are described as biomarkers expressed by stem cells, as confirmed in our previous studies [ 88 , 89 ].…”

Section: Cscs In Head and Neck Cancersupporting

confidence: 85%

“…SOX2 (Sex determining region Y-box 2) is a nuclear transcription factor that plays a crucial role in the development of pluripotent cells [ 100 ]. SOX2 induces various signal transduction pathways like tumorigenesis, inhibition of apoptosis, migration, invasion, and resistance to radio/chemotherapy [ 6 , 7 , 88 ]. Increased transcriptional activity of SOX2 seems to be critical for HNSCC growth and development [ 78 , 98 ].…”

Section: Cscs In Head and Neck Cancermentioning

confidence: 99%

“…This hypothesis was confirmed by other authors, who found a correlation between SHH and SOX2 in OSCC. The subset of tumors with co-expression of both biomarkers showed resistance to standard therapy and a shorter survival time [ 88 ].…”

Section: The Role Of Hh Signaling In Hnscc Tumorigenesismentioning

confidence: 99%

“… The schematic view of cancer stem cells (CSCs) in head and neck squamous cell carcinoma tissue with expression of main cell surface markers (CD44 and CD133), transcription factors (SOX2 and NANOG), and selected molecules belonging to crucial signaling pathways (SHH, WNT1, and NOTCH1). Immunohistochemical images were adapted from our previous studies [ 88 , 89 ]. …”

Section: Figurementioning

confidence: 99%

See 3 more Smart Citations

The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma

Cierpikowski,

Leszczyszyn,

Bar

2023

Cells

Self Cite

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy worldwide, with a poor prognosis and limited treatment options. Molecularly targeted therapies for HNSCC are still lacking. However, recent reports provide novel insights about many molecular alterations in HNSCC that may be useful in future therapies. Therefore, it is necessary to identify new biomarkers that may provide a better prediction of the disease and promising targets for personalized therapy. The poor response of HNSCC to therapy is attributed to a small population of tumor cells called cancer stem cells (CSCs). Growing evidence indicates that the Hedgehog (HH) signaling pathway plays a crucial role in the development and maintenance of head and neck tissues. The HH pathway is normally involved in embryogenesis, stem cell renewal, and tissue regeneration. However, abnormal activation of the HH pathway is also associated with carcinogenesis and CSC regulation. Overactivation of the HH pathway was observed in several tumors, including basal cell carcinoma, that are successfully treated with HH inhibitors. However, clinical studies about HH pathways in HNSCC are still rare. In this review, we summarize the current knowledge and recent advances regarding the HH pathway in HNSCC and discuss its possible implications for prognosis and future therapy.

show abstract

Section: Cscs In Head and Neck Cancersupporting

confidence: 85%

Section: Cscs In Head and Neck Cancermentioning

confidence: 99%

Section: The Role Of Hh Signaling In Hnscc Tumorigenesismentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

See 2 more Smart Citations

The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma

Cierpikowski,

Leszczyszyn,

Bar

2023

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

“…HH signaling molecules are considered to be prognostic indicators in OSCC as overexpression of related proteins can be indicative to tumor size, metastatic potential, tumor recurrence and even to shorter overall survival. 202 , 203 HH signaling regulates cell proliferation in OSCC. 204 Several studies have investigated the molecular mechanisms on the invasion behavior of human OSCC.…”

Section: Hedgehog Signaling In Cancermentioning

confidence: 99%

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies

Jing,

Wu,

Wang

et al. 2023

Sig Transduct Target Ther

View full text Add to dashboard Cite

The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer. A variety of drugs have been developed, including small molecule inhibitors, natural compounds, and long non-coding RNA (LncRNA), some of which are approved for clinical use. This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer. Furthermore, we address status quo and limitations of targeted therapies of HH signaling pathway. Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer, as well as opportunities and challenges of therapeutic targets for cancer.

show abstract

Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study

Gao,

Yan,

Jiang

et al. 2024

International Journal of Genomics

View full text Add to dashboard Cite

Aim. To investigate the specific expression profile, clinicopathological significance and mechanism of Zic family member 2 (ZIC2) in oral cancer were unclear. Patients and Methods. We explored the expression pattern and clinicopathological significance of ZIC2 in oral cancer through performing in-house tissue microarray and integrated analysis global RNA-seq and microarrays containing large samples. The molecular basis of ZIC2 in oral cancer was further investigated in the aspects of transcription network and immune correlations. We also performed in vitro experiments and calculated drug sensitivity of oral cancer with different ZIC2 expression levels in response to hundreds of compounds. Results. All data unanimously proved the significant overexpression of ZIC2 in oral cancer. The upregulation of ZIC2 was remarkably associated with the malignant clinical progression of oral cancer. ZIC2 was predicted to be targeted by miRNAs such as miR-3140, miR-4999, and miR-1322. The infiltration level of CD8+ T and central memory cells was positively related to the overexpression of ZIC2. Oral cancer patients with higher ZIC2 expression showed higher drug sensitivity to two compounds including AZD8186 and ERK_2240. Conclusions. We demonstrated the upregulation of ZIC2 in oral cancer and its promoting effect on the clinical advancement of oral cancer. The potential clinical value of ZIC2 in oral cancer deserves attention.

show abstract

SHH Expression Is Significantly Associated With Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma

Cited by 7 publications

References 0 publications

The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma

The Role of Hedgehog Signaling Pathway in Head and Neck Squamous Cell Carcinoma

Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies

Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study

Contact Info

Product

Resources

About