Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway

Zhou, Shanshan; Ai, Zhongzhu; Li, Weinan; Li, Liang; Zhu, Xiaoyun; Ba, Yi

doi:10.1007/s11596-020-2255-4

Cited by 7 publications

(3 citation statements)

References 53 publications

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“…Moreover, IκB kinase (IKK) mediated phosphorylation of IκB marks it for proteasomal degradation that triggers the migration of NF-κB to the nucleus and transcription of genes encoding chemotactic and inflammatory factors. 45 Consistent with earlier studies, 46,47 our findings confirmed augmented renal expression of phospho-NF-κB ( p65), COX-2 proteins, and gene encoding IL-6, VCAM-1, and MCP-1 in the UUO control group. Interestingly, CVL administration alleviates kidney inflammation by intercepting the expression of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6), chemokine (MCP-1), adhesion molecule (VCAM-1), and inhibiting the phosphorylation of NF-κB protein.…”

Section: Food and Function Papersupporting

confidence: 91%

Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation

et al. 2022

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Section: Food and Function Papersupporting

confidence: 91%

Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation

et al. 2022

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“…Studies have shown that it can improve renal function by reducing ECM deposition in the kidney and the expression of inflammatory mediators. In addition, the Shenkang VII recipe inhibited the activation of TGF/Smad, NF-kB, and SHH signal transduction in UUO rats, slowing the progression of renal fibrosis ( Zhou et al, 2020 ). Dioscorea, a common Chinese herbal medicine.…”

Section: Mechanisms Of Rif Interventionmentioning

confidence: 99%

Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

et al. 2022

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Chronic kidney diseases usually cause renal interstitial fibrosis, the prevention, delay, and treatment of which is a global research hotspot. However, no definite treatment options are available in modern medicine. Chinese herbal medicine has a long history, rich varieties, and accurate treatment effects. Hitherto, many Chinese herbal medicine studies have emerged to improve renal interstitial fibrosis. This paper reviews the mechanisms of renal interstitial fibrosis and recent studies on the disease intervention with Chinese herbal medicine through literature search, intend to reveal the importance of Chinese herbal medicine in renal interstitial fibrosis. The results show that Chinese herbal medicine can improve renal interstitial fibrosis, and the effects of Chinese herbal medicine on specific pathological mechanisms underlying renal interstitial fibrosis have been explored. Additionally, the limitations and advantages of Chinese herbal medicine in the treatment of renal interstitial fibrosis, possible research directions, and new targets of Chinese herbal medicine are discussed to provide a basis for studies of renal interstitial fibrosis.

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“…Due to changes in renal hemodynamics, macrophages in the interstitial tubules may be activated to release inflammation-related cytokines such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) or activate the expression of related genes like the aggregation of vascular smooth muscle actin (α-SMA) and β-catenin, eventually leading to inflammation and fibrosis ( Bai et al, 2021 ). The severity of the disease is closely related to the progression of renal failure, therefore, in the state of UUO, a series of pathological changes will appear in the kidney and these changes play a key role in the process of promoting irreversible renal damage ( Zhou et al, 2020a ; Kido et al, 2017 ; Ma et al, 2016 ; Wang et al, 2018 ; You et al, 2019 ; Lee, Kim & Choi, 2015 ). Tammaro et al (2013) reported that the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) positive cells may be closely related to inflammation and fibrosis in the kidney, and more interestingly, its role may be achieved by amplifying the inflammatory signal of TLR4.…”

Section: Introductionmentioning

confidence: 99%

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

Mao

et al. 2023

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Purpose Acteoside (Act), a phenylethanoid compound that was first isolated from mullein, has been widely used for the investigation of anti-inflammatory and anti-fibrotic effect. However, the mechanism of Act against unilateral ureteral obstruction (UUO)-mediated renal injury is largely unknown. Therefore, this study aimed to explore the effects of Act on UUO rats and possible mechanisms. Methods A total of 20 Sprague-Dawley (SD) rats were divided randomly into three groups (n ≥ 6): (i) sham-operated group (Sham); (ii) UUO group (UUO+Saline); and (iii) UUO + Act 40 mg/kg/day, (UUO+Act); Continuous gavage administration for 2 weeks postoperatively, while the rats in Sham and UUO+saline groups were given equal amounts of saline. All rats were sacrificed after 14 days, the urine and blood samples were collected for biochemical analysis, the renal tissues were collected for pathological staining and immunohistochemistry. Correlations between individual proteins were analyzed by Pearson correlation analysis. Results The results of renal function indexes and histopathological staining showed that Act could improve renal function by reducing serum creatinine, blood urea nitrogen and urine protein at the same time, Act could alleviate renal inflammation and fibrosis. In addition, the results of immunohistochemistry showed that Act could reduce the expression of inflammation and kidney injury-related proteins F4/80, Mcp-1, KIM-1 proteins, as well as the expression of fibrosis-related protein α-SMA and β-catenin. More importantly, Act can also reduce the expression of HMGN1, TLR4 and TREM-1 proteins. Conclusion These data demonstrate that Act can ameliorate UUO-induced renal inflammation and fibrosis in rats probably through triggering HMGN1/TLR4/TREM-1 pathway.

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Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway

Cited by 7 publications

References 53 publications

Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation

Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation

Research Progress of Chinese Herbal Medicine Intervention in Renal Interstitial Fibrosis

Acteoside alleviates UUO-induced inflammation and fibrosis by regulating the HMGN1/TLR4/TREM1 signaling pathway

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