Shell-cross-linking of polymeric micelles by Zn coordination for Photo- and pH dual-sensitive drug delivery

Molecular Design and Controlled Self-Assembly of Copolymers as Core–Shell–Corona Nanoparticles for Smarter Tumor Treatment

“…Du and Zhao’s group designed shell-cross-linked polymeric micelle-based DDSs for the photo- and pH dual-responsive drug delivery by the co-self-assembly of DOX with poly­(1-nitrobenzyl)­ether methacrylate- b -(poly­( N -3-imidazolylpropyl) methacrylamide- b -poly­[poly­(ethylene glycol) methyl ether methacrylate] (PNBMA- b -PImPM 10 - b -P­(P­(EG) 5 MA) 9 ), which was synthesized via sequential RAFT polymerization, followed by cross-linking with Zn 2+ ions . The premature drug leakage was significantly minimized in comparison with that of non-cross-linked ones; however, the drug release in the tumor intracellular microenvironment was also inhibited.…”

Post cross-linked ROS-responsive poly(β-amino ester)-plasmid polyplex NPs for gene therapy of EBV-associated nasopharyngeal carcinoma

“…21 Cross-linking is an effective strategy to prevent the leakage of drugs from NPs/micelles and increase the stability. 44,45 However, the balance of stability of NPs/micelles and cargo release kinetics after cross-linking are challenges in application. Introducing stimuli-responsive cross-linking bonds is a meaningful method to address this problem.…”