Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel

Hu, Fuqiang; Guo-fei, Ren; Yuan, Hong; Du, Yong‐Zhong; Zeng, Su

doi:10.1016/j.colsurfb.2006.04.009

Cited by 200 publications

(125 citation statements)

References 27 publications

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“…17 In our previous studies, stearic acid-grafted CS (CS-SA) was synthesized using low molecular-weight CS, which was able to form micelle-like nanoparticles in the aqueous phase, and has been used to deliver gene 18 and antitumor agents like doxorubicin 19,20 and paclitaxel. 21 All the results demonstrated the excellent biomembrane penetration ability of CS-SA, indicated by rapid in vitro cellular uptake and comparable in vivo therapeutic effect with a commercial agent. Moreover, the micelles were able to reserve multidrug resistance by avoiding recognition by P-gp.…”

Section: Introductionmentioning

confidence: 75%

Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system

Xie¹,

Du²,

Yuan³

et al. 2012

IJN

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Purpose: Therapy for central nervous system disease is mainly restricted by the blood-brain barrier. A drug-delivery system is an effective approach to overcome this barrier. In this research, the potential of polymeric micelles for brain-targeting drug delivery was studied. Methods: Stearic acid-grafted chitosan (CS-SA) was synthesized by hydrophobic modification of chitosan with stearic acid. The physicochemical characteristics of CS-SA micelles were investigated. bEnd.3 cells were chosen as model cells to evaluate the internalization ability and cytotoxicity of CS-SA micelles in vitro. Doxorubicin (DOX), as a model drug, was physically encapsulated in CS-SA micelles. The in vivo brain-targeting ability of CS-SA micelles was qualitatively and quantitatively studied by in vivo imaging and high-performance liquid chromatography analysis, respectively. The therapeutic effect of DOX-loaded micelles in vitro was performed on glioma C6 cells. Results:The critical micelle concentration of CS-SA micelles with 26.9% ± 1.08% amino substitute degree was 65 µg/mL. The diameter and surface potential of synthesized CS-SA micelles in aqueous solution was 22 ± 0.98 nm and 36.4 ± 0.71 mV, respectively. CS-SA micelles presented excellent cellular uptake ability on bEnd.3 cells, the IC 50 of which was 237.6 ± 6.61 µg/mL. DOX-loaded micelles exhibited slow drug-release behavior, with a cumulative release up to 72% within 48 hours in vitro. The cytotoxicity of DOX-loaded CS-SA micelles against C6 was 2.664 ± 0.036 µg/mL, compared with 0.181 ± 0.066 µg/mL of DOX ⋅ HCl. In vivo imaging results indicated that CS-SA was able to transport rapidly across the blood-brain barrier and into the brain. A maximum DOX distribution in brain of 1.01%/g was observed 15 minutes after administration and maintained above 0.45%/g within 1 hour. Meanwhile, free DOX ⋅ HCl was not detected in brain. In other major tissues, DOX-loaded micelles were mainly distributed into lung, liver, and spleen, with a reduction of DOX accumulation in heart. Conclusion: The CS-SA micelles were able to be used as a promising carrier for a braintargeting drug delivery system.

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Section: Introductionmentioning

confidence: 75%

Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system

Xie¹,

Du²,

Yuan³

et al. 2012

IJN

Self Cite

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“…When the surfaces of micelles were cross-linked by glutaraldehyde, the burst release of the micelles at earlier stage was highly improved and the drug release time was prolonged. By controlling the amino substitution of stearic-grafted chitosan and the crosslink degree, the prolonged and controlled release could be achieved (Hu et al, 2006).…”

Section: Doxorubicin (Dox)mentioning

confidence: 99%

“…Hu and coworkers employed a similar methodology in order to obtain stearic acidchitosan nanoparticles. To increase the stability of the micelle in vivo and controlled drug release, the shells of micelles were cross-linked by glutaraldehyde (Hu et al, 2006). Dextran has been also employed to obtain nanoparticles by coupling lipoic acid to the structure of dextran and forming nanoparticles in water, whose size varied from 145 to 221 nm (Li et al, 2009).…”

Section: Nanoparticles Obtained From Self-assembling Of Hydrophobicalmentioning

confidence: 99%

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Martı́nez¹,

Fernandez²,

Pérez³

et al. 2012

The Delivery of Nanoparticles

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“…The loading capacity of hydrophobic model drug ibuprofen in the micelles was about 10%. Also stearic acid grafted chitosan oligosaccharide by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimidemediated coupling reaction was synthesized (Hu et al, 2006). The CMC of the copolymer was approximately 0.06, 0.04, 0.01 mg/ml respectively.…”

Section: Linear Hydrophobic Moleculesmentioning

confidence: 99%

Nanoparticles Based on Modified Polysaccharides

Namazi¹,

Fathi²,

Heydari³

2012

The Delivery of Nanoparticles

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Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel

Cited by 200 publications

References 27 publications

Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system

Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Nanoparticles Based on Modified Polysaccharides

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Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel

Cited by 200 publications

References 27 publications

Brain-targeting study of stearic acid&ndash;grafted chitosan micelle drug-delivery system

Brain-targeting study of stearic acid&ndash;grafted chitosan micelle drug-delivery system

Polysaccharide-Based Nanoparticles for Controlled Release Formulations

Nanoparticles Based on Modified Polysaccharides

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Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system

Brain-targeting study of stearic acid–grafted chitosan micelle drug-delivery system