Shell Cross-Linked Nanoparticles Designed To Target Angiogenic Blood Vessels via α<sub>v</sub>β<sub>3</sub> Receptor−Ligand Interactions

Pan, Dipanjan; Turner, Jeffrey L.; Wooley, Karen L.

doi:10.1021/ma048824e

Cited by 55 publications

(47 citation statements)

References 30 publications

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“…[24,[29][30][31][32][33][34][35] In general, with the introduction of appropriate functionalities into selective regions within the nanostructures, it is possible to tailor the nanoparticles and micelles for enhanced performance toward both higher selectivity and loading for drug targeting, among other applications. [36] In this fundamental study, therefore, nanoparticles were designed and synthesized to present Click-readied functionalities throughout the core region, which were then probed as possible therapeutic and imaging agent attachment sites via reaction with the profluorophore 3-azidocoumarin. Click chemistry is a modular synthetic approach that couples an acetylene and azide via a regioselective 1,3-dipolar cycloaddition reaction in the presence of a copper catalyst, to afford a 1,4-disubstituted 1,2,3-triazole ring.…”

Section: Introductionmentioning

confidence: 99%

Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle

O’Reilly

Joralemon

Hawker

et al. 2006

Chemistry A European J

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146

102

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Using either nitroxide mediated polymerization (NMP) or reversible addition fragmentation transfer (RAFT) techniques, novel block copolymers that present terminal acetylenes, in the side chain of the styrenic block, were obtained with narrow polydispersities and targeted molecular weights. For the conversion of these acetylene-functionalized polymers to amphiphilic block copolymers, RAFT techniques were preferred. Mild protection/deprotection chemistries were employed which were compatible with the incorporation of the acetylene functionality in the hydrophobic segment. These acetylene-functionalized, Click-readied amphiphilic block copolymers were then self-assembled and cross-linked to afford shell cross-linked knedel-like (SCK) nanoparticles that contained acetylene groups in the core domain. The hydrodynamic diameters (D(h)) of the block copolymer micelles and nanoparticles were determined by dynamic light scattering (DLS), and the dimensions of the nanoparticles were characterized using tapping-mode atomic force microscopy (AFM) and transmission electron microscopy (TEM). The chemical availability of the Click functionality within the core domain of the SCKs was investigated using the copper(I)-catalyzed 1,3-dipolar fluorogenic cycloaddition with a non-fluorescent 3-azidocoumarin profluorophore to afford intensely fluorescent nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle

O’Reilly

Joralemon

Hawker

et al. 2006

Chemistry A European J

Self Cite

146

102

View full text Add to dashboard Cite

show abstract

“…Living polymerization provides a facile entry to the synthesis of block copolymers, which often self-assemble in solution to form well-defined structures such as monolayers, films, micelles, vesicles, and helices. Applications in the biomedical field include general [6] and targeted drug delivery, [7] and imaging of cancer cells. [8] NMP is effective with styrenes, dienes, and many electron-poor vinyl monomers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Self‐Assembly of Amphiphilic Diblock Copolymers using a Fluorescently Labeled N‐Alkoxyamine Initiator

Tsimelzon¹,

Deamer²,

Braslau³

2005

Macromol. Rapid Commun.

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Summary: An initiator for nitroxide mediated ‘living’ free radical polymerization was prepared with a fluorescent tag attached to the initiating alkyl radical terminus. This was used to synthesize amphiphilic poly(acrylic acid)‐block‐polystyrene diblock copolymers, which self assembled in a tetrahydrofuran/buffer solution to form structures that are visible by fluorescence. magnified image

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“…In recent years, a wide range of different nanoscale drug delivery vectors have been evaluated (Pan et al, 2004;Chithrani et al, 2006;Endo et al, 2008). Notably, single-walled carbon nanotubes (SWCNTs) have attracted considerable interest in this regard, as they offer potential advantages over the more widely studied metal nanoparticle systems.…”

Section: Carbon Nanotubes and Their Impor-tance In Anticancer Drug Dementioning

confidence: 99%

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha¹,

Ghoshal²,

Kumar³

et al. 2013

Braz. J. Pharm. Sci.

113

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Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.Uniterms: Carbon nanotubes/properties. Carbon nanotubes/use/drugs delivery. Single-Walled Carbon Nanotube. Multiwalled Carbon Nanotube. Anticancer drugs/delivery. Cancer/therapy. Drugs/delivery.Os nanotubos de carbono foram descobertos em 1991 e suas propriedades físico-químicas únicas demonstradas, despertando interesse em sua aplicação em vários campos, incluindo a entrega liberação de fármacos. As propriedades únicas dos nanotubos de carbono, tais como a facilidade de captação pela célula, carga alta de fármaco, ablação térmica, entre outras, tornaram-nos úteis para terapia de câncer, uma das doenças mais difíceis dos tempos modernos, pois sua terapia envolve a distinção entre as células normais saudáveis e as afetadas pela doença. Os nanotubos de carbono têm um papel importante nessa área porque fenômenos como EPR permitem que estes possam distinguir as células normais das afetadas, que é o Santo Graal na terapia do câncer. Trabalho considerável tem sido feito ao longo das duas últimas década com nanotubos de carbono, como sistemas de liberação de fármacos. No entanto, preocupações sobre algumas questões, como biocompatibilidade e toxicidade, surgiram ao longo do tempo, demandando extensas pesquisa nesse campo. Unitermos: Nanotubos de carbono/propriedades. Nanotubos de carbono/uso/liberação de fármacos. Nanotubo de carbono de parede única. Nanotubo de parede múltipla. Fármacos anticancer/liberação. Cancer/tratamento. Fármacos/liberação.

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Shell Cross-Linked Nanoparticles Designed To Target Angiogenic Blood Vessels via α_vβ₃ Receptor−Ligand Interactions

Cited by 55 publications

References 30 publications

Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle

Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle

Synthesis and Self‐Assembly of Amphiphilic Diblock Copolymers using a Fluorescently Labeled N‐Alkoxyamine Initiator

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

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Shell Cross-Linked Nanoparticles Designed To Target Angiogenic Blood Vessels via αvβ3 Receptor−Ligand Interactions

Cited by 55 publications

References 30 publications

Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle

Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle

Synthesis and Self‐Assembly of Amphiphilic Diblock Copolymers using a Fluorescently Labeled N‐Alkoxyamine Initiator

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

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Resources

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Shell Cross-Linked Nanoparticles Designed To Target Angiogenic Blood Vessels via α_vβ₃ Receptor−Ligand Interactions