Shedding light on cholecystokinin’s role in hippocampal neuroplasticity and memory formation

Asim, Muhammad; Wang, Huajie; Chen, Xi

doi:10.1016/j.neubiorev.2024.105615

Cited by 2 publications

(1 citation statement)

References 104 publications

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“…Our previous studies have underscored the dentate gyrus' heightened susceptibility to the impacts of aging and sedentary lifestyles, particularly evident in rats raised in larger litters [29]. Furthermore, the hippocampus is implicated in both object recognition and spatial memory in both human and experimental models [36][37][38][39][40][41]. Neuroanatomical tracing has revealed intricate projections of perforant pathways onto dentate granule cells within the dentate gyrus, originating from layer two principal neurons of the entorhinal cortex (EC) and forming synapses at granule cell dendrites in the outer two-thirds of the molecular layer [42].…”

Section: Introductionmentioning

confidence: 93%

Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats

Krejcová,

Bento-Torres,

Diniz

et al. 2024

Brain Sciences

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This study explores the multifaceted influence of litter size, maternal care, exercise, and aging on rats’ neurobehavioral plasticity and dentate gyrus microglia dynamics. Body weight evolution revealed a progressive increase until maturity, followed by a decline during aging, with larger litters exhibiting lower weights initially. Notably, exercised rats from smaller litters displayed higher body weights during the mature and aged stages. The dentate gyrus volumes showed no significant differences among groups, except for aged sedentary rats from smaller litters, which exhibited a reduction. Maternal care varied significantly based on litter size, with large litter dams showing lower frequencies of caregiving behaviors. Behavioral assays highlighted the detrimental impact of a sedentary lifestyle and reduced maternal care/large litters on spatial memory, mitigated by exercise in aged rats from smaller litters. The microglial dynamics in the layers of dentate gyrus revealed age-related changes modulated by litter size and exercise. Exercise interventions mitigated microgliosis associated with aging, particularly in aged rats. These findings underscore the complex interplay between early-life experiences, exercise, microglial dynamics, and neurobehavioral outcomes during aging.

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Section: Introductionmentioning

confidence: 93%

Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats

Krejcová,

Bento-Torres,

Diniz

et al. 2024

Brain Sciences

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Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

Asim,

Wang,

Waris

et al. 2024

BioFactors

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Cholecystokinin (CCK) plays a key role in various brain functions, including both health and disease states. Despite the extensive research conducted on CCK, there remain several important questions regarding its specific role in the brain. As a result, the existing body of literature on the subject is complex and sometimes conflicting. The primary objective of this review article is to provide a comprehensive overview of recent advancements in understanding the central nervous system role of CCK, with a specific emphasis on elucidating CCK's mechanisms for neuroplasticity, exploring its interactions with other neurotransmitters, and discussing its significant involvement in neurological disorders. Studies demonstrate that CCK mediates both inhibitory long‐term potentiation (iLTP) and excitatory long‐term potentiation (eLTP) in the brain. Activation of the GPR173 receptor could facilitate iLTP, while the Cholecystokinin B receptor (CCKBR) facilitates eLTP. CCK receptors' expression on different neurons regulates activity, neurotransmitter release, and plasticity, emphasizing CCK's role in modulating brain function. Furthermore, CCK plays a pivotal role in modulating emotional states, Alzheimer's disease, addiction, schizophrenia, and epileptic conditions. Targeting CCK cell types and circuits holds promise as a therapeutic strategy for alleviating these brain disorders.

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Shedding light on cholecystokinin’s role in hippocampal neuroplasticity and memory formation

Cited by 2 publications

References 104 publications

Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats

Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats

Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease

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