Shear wave elastography as a new, non-invasive diagnostic modality for the diagnosis of penile elasticity: a prospective multicenter study

Illiano, Ester; Trama, Francesco; Ruffo, A; Riezzo, Giuseppe; Riccardo, Filippo; Iacono, Fabrizio

doi:10.1177/17562872211007978

Cited by 14 publications

(13 citation statements)

References 37 publications

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“…SWE is an operator-independent method that can be easily reproduced [15,16]. Moreover, it can be used to obtain a quantitative value of the analyzed tissue and to eventually compare the results obtained following the targeted treatments [17].…”

Section: Discussionmentioning

confidence: 99%

Testicular shear wave elastography in oligo-astheno-teratozoospermic individuals: a prospective case–control study

Illiano

Trama

Ruffo³

et al. 2021

Int Urol Nephrol

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Purpose The primary objective of this study was to evaluate the testicular stiffness by ultrasound shear wave elastography (SWE) both in men with oligo-astheno-teratozospermia (OAT) and in control group. The secondary objective was to identify a possible correlation between semen quality with testicular stiffness. Methods This was a prospective case-control study. We divided the sample in two groups; Group A (case group) included men with OAT, and Group B (control group) men with normal sperm parameters. All participants had at last two semen analysis in the past 180 days (at last 90 days apart), using performed ultrasound and SWE elastography. Results We analyzed 100 participants, 50 patients in Group A and 50 controls in Group B. There were statistically significant differences in term of testicular volume and testicular stiffness between two groups. Men with OAT had the testicular stiffness value higher than the controls in both sides (left testicular stiffness 21.4 ± 5.4 kPa vs 9.9 ± 1.6 kPa, p < 0.0001; right testicular stiffness 22.9 ± 4.8 kPa vs 9.5 ± 2.4 kPa, p < 0.0001). Men with abnormal semen parameters showed an inverse correlation between the mean value of testicular stiffness and total sperm count (22.15 ± 3.38 kPa, r = − 0.387, p = 0.005), sperm concentration (22.15 ± 3.38 kPa, r = − 0.244, p = 0.04), and progressive motility (22.15 ± 3.38 kPa, r = − 0.336, p = 0.01), while the correlation was not evident in controls group. Conclusion SWE is able to differentiate between testicles with spermatogenic changes from a healthy testicle. For this reason, it could be used to evaluate, in a non-invasive way, the tissue alterations of the organ.

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Section: Discussionmentioning

confidence: 99%

Testicular shear wave elastography in oligo-astheno-teratozoospermic individuals: a prospective case–control study

Illiano

Trama

Ruffo³

et al. 2021

Int Urol Nephrol

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“…In another study, Zhang et al [ 29 ] measured penile elasticity in erectile dysfunction patients and PD patients before and after a pharmacologically induced erection. They reported that there was a significant increase in viscoelasticity in patients with pharmacologically induced erections, demonstrating that SWE could be used to measure dynamic changes in erection [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Illiano et al [ 30 ] analyzed 270 patients with various degrees of erectile dysfunction and observed a correlation between the worsening of IIEF-15 score and a higher degree of penile stiffness demonstrated by the erection hardness score; they also observed a reduction in elasticity demonstrated by an increase in kPa values diagnosed by SWE.…”

Section: Discussionmentioning

confidence: 99%

Use of penile shear wave elastosonography for the diagnosis of Peyronie’s Disease: a prospective case–control study

Trama

Illiano

Iacono

et al. 2022

Basic Clin. Androl.

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Background To evaluate the stiffness of the tunica albuginea (TA), we used a new noninvasive diagnostic technique called shear wave elastography (SWE). We determined whether SWE values are correlated with the degree of penile curvature, the time of disease onset, and pain severity experienced by patients during erection. This study analyzed the elasticity of the TA of patients with Peyronie’s disease compared to that of the control group. We also analyzed any correlations between the stiffness of the cavernous bodies and the degree of curvature, time from diagnosis to curvature onset, and erectile pain severity. This was a prospective case–control study involving 100 men enrolled from September 2020 to August 2021. Participants were divided into group A (case group, n = 50), which included men with PD, with or without pain, and with penile curvature, or group B (control group, n = 50), which included healthy patients older than 18 years who visited the urology clinic for reasons other than PD. The medical history was collected for all patients who also underwent objective examination, B-mode ultrasound evaluation, and SWE. The International Index of Erectile Function (IIEF-15) visual analog scale (VAS) questionnaire was administered to all participants. Results There were no significant between-group differences regarding age, weight, and height (p > 0.05); however, there was a significant difference in the stiffness values (p < 0.05). An inverse correlation was observed between stiffness and the VAS score (p < 0.0001). A positive correlation was observed between the degree of curvature (p < 0.0001) and the time of curvature onset (p < 0.0001). The IIEF-15 scores were poorer in group A than in group B (p < 0.0001). Conclusion SWE is an inexpensive, noninvasive method that can be used to measure the stiffness of PD patients.

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“…In their study, the rate of the patients with psychogenic ED in the ED group was unclear, and this may have affected the research findings. On the contrary, Illiano et al determined that SWE was negatively correlated with IIEF-5 and erection hardness score [ 25 ]. The findings of our study are consistent with the study of Illiano et al…”

Section: Discussionmentioning

confidence: 99%

The role of penile elastography in the evaluation of erectile dysfunction in patients with chronic obstructive pulmonary disease

Yenice

Danacıoğlu

Türkay

et al. 2022

Cent european J Urol

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Introduction In this study, we aimed to measure the change in penile stiffness by evaluating corpus cavernosum (CC) with shear wave elastography (SWE) in patients with chronic obstructive pulmonary disease (COPD). Material and methods Seventy outpatient patients aged 50–80 years who were diagnosed with COPD were evaluated using SWE. Patients were divided into 2 groups according to the International Index of Erectile Function-5 (IIEF-5) questionnaire (IIEF-5 >17: Group A, IIEF-5 <17: Group B). The measurements were made in both transverse and longitudinal sections. Results The mean age of the patients was 60 ±7.9 years. The duration of COPD was significantly higher in Group B than in Group A (p = 0.003). The mean SWE values of right transverse mid-portion of corpus penis (RTM) and left transverse mid-portion of corpus penis (LTM) in Group B (21.1 ±5.6 kPa and 20.8 ±4.8 kPa, respectively) were significantly higher than in Group A (15.2 ±2.3 kPa and 15.8 ±2.7 kPa, respectively); (p <0.001 and p <0.001, respectively). There was a significant negative correlation between IIEF-5 scores and the duration of COPD (p <0.05). There was a significant negative correlation between IIEF values and RTM and LTM values of the patients (p <0.05 and p <0.05, respectively). There was a significant positive correlation between the duration of COPD and both RTM and LTM values (p <0.05 and p <0.05, respectively). Conclusions In our study, according to the SWE findings, we showed the effect of systemic changes created by COPD on penile tissue and the negative effect of this on erectile function in patients.

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Shear wave elastography as a new, non-invasive diagnostic modality for the diagnosis of penile elasticity: a prospective multicenter study

Cited by 14 publications

References 37 publications

Testicular shear wave elastography in oligo-astheno-teratozoospermic individuals: a prospective case–control study

Testicular shear wave elastography in oligo-astheno-teratozoospermic individuals: a prospective case–control study

Use of penile shear wave elastosonography for the diagnosis of Peyronie’s Disease: a prospective case–control study

The role of penile elastography in the evaluation of erectile dysfunction in patients with chronic obstructive pulmonary disease

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