Shear wave elastography as a quantitative method for thyroid gland elasticity assessment in pediatrics patients with autoimmune-related thyroid disease, diagnostic utility and laboratory correlation

Kamel, Sara Mahmoud; ElKhashab, Khaled; Bhagat, Suchi; Elzayat, Wessam Abdelrahman

doi:10.1186/s43055-022-00882-1

Cited by 3 publications

(4 citation statements)

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“…While some studies have found a mild correlation between EI and ATG and a moderate correlation with ATPO [37], others have found no correlation between EI and antibody levels [41,42]. In addition, Kamel et al found correlations between elasticity and antibody levels to be statistically insignificant (p > 0.05) [39]. Kandemirli et al found a moderate correlation between elasticity and ATPO, but a non-significant correlation between EI and ATG (p > 0.05) [36].…”

Section: Discussionmentioning

confidence: 99%

“…Patients diagnosed with CAT had elasticity values that were considerably greater (35.6 kPa, with an interquartile range of 8.43-103.7 kPa) than the control group (9.35 kPa, with an interquartile range of 5.73-13.21 kPa). The threshold value for elasticity was determined to be 12.317 kPa, and the sensitivity and specificity of the test were 96.9% and 100%, respectively [39].…”

Section: Discussionmentioning

confidence: 99%

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A Comparative Analysis of Strain and 2D Shear Wave Elastography in the Diagnosis of Autoimmune Thyroiditis in Pediatric Patients

et al. 2023

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This paper aims to assess the usefulness of shear-wave elastography (SWE) and strain elastography (SE) for identifying and monitoring thyroid gland changes in children diagnosed with chronic autoimmune thyroiditis (CAT). Our study included 77 children between the ages of six and eighteen. Of these, 45 were diagnosed with CAT, while 32 had no thyroid pathology. Following a clinical examination and laboratory tests, an ultrasound was carried out, and then a SE (using a Hitachi Preirus machine) and SWE (using an Aixplorer Mach 30, Supersonic imagine, France) were performed in the same session. The median thyroid elastic index (EI) in the CAT group was 13.8 (13.3–17) kPa compared to 10.1 (9.3–11.2) kPa in healthy children (p < 0.0001). We found a median strain ratio (SR) of 1.2 (1.2–1.3) for CAT compared to 0.7 (0.6–0.9) for healthy thyroid tissue (p < 0.0001). The optimal cut-off value for predicting the presence of CAT in children using SR was >1 (Se = 82.2%, Sp = 87.5%, PPV = 90.2%, and NPV = 77.8%, AUROC = 0.850), while using SWE, the optimal cut-off value for predicting the presence of CAT in children was >12 kPa (Se = 88.9%, Sp = 93.7%, PPV = 95.2%, and NPV = 85.5%, AUROC = 0.943). Both techniques are useful for measuring thyroid tissue elasticity, and their diagnostic accuracy and reliability are comparable.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of Strain and 2D Shear Wave Elastography in the Diagnosis of Autoimmune Thyroiditis in Pediatric Patients

et al. 2023

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“…Kamel et al [ 43 ], in their study evaluating thyroid gland elasticity in pediatric patients with autoimmune thyroid disease, found thyroid SWE values to be significantly higher in children with autoimmune thyroiditis compared to healthy children due to parenchymal stiffness caused by lymphocytic infiltration and interstitial fibrosis. In the literature, a proportionally higher increase in tissue stiffness values has been found in autoimmune thyroiditis.…”

Section: Discussionmentioning

confidence: 99%

Can Shear Wave Elastography Help Differentiate Acute Tonsillitis from Normal Tonsils in Pediatric Patients: A Prospective Preliminary Study

Ece

Aydın

2023

Children

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Shear wave elastography (SWE) is a non-invasive imaging technique used to quantify the elasticity/stiffness of any tissue. There are normative SWE studies on tonsils in healthy children in the literature. The purpose of this study is to analyze the palatine tonsils in children with acute tonsillitis using ultrasound and SWE. In this prospective study, pediatric patients aged 4–18 years diagnosed with acute tonsillitis and healthy children were included. Those with antibiotic use, chronic tonsillitis, adenoid hypertrophy, and having chronic disease, immunodeficiency, and autoimmune disease, or any rheumatological disease were excluded. The volume and elasticity of palatine tonsil were measured via ultrasound and SWE. The study included 81 (46 female, 35 male) acute tonsillitis patients, and 63 (38 female, 25 male) healthy children between the ages of 4 and 18. Elasticity (kPa) values of tonsils were found significantly higher in the tonsillitis group (SWE-R: 25.39 ± 4.64, SWE-L: 25.01 ± 4.17) compared to the normal group (SWE-R: 9.71 ± 2.37, SWE-L: 9.39 ± 2.19) (p < 0.001). In the tonsillitis group, a significant positive correlation was found between tonsil volume and elasticity (r: 0.774, p: 0.002). In conclusion, in pediatric patients with acute tonsillitis, higher kPa values were obtained with SWE in the palatine tonsils.

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“…Extrapolating the excellent results observed in the diffuse chronic liver disease, elastography was used in the differential diagnosis of DTD from normal thyroid. Both strain and 2D-shear wave elastography (2D-SWE) demonstrated increased stiffness in autoimmune thyroid disease compared with normal thyroid ( 35 , 36 ), both in adult ( 37 ) and pediatric populations ( 38 , 39 ).…”

Section: Introductionmentioning

confidence: 99%

Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease

Stoian,

Borlea,

Moisa-Luca

et al. 2023

Front. Endocrinol.

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IntroductionHyperthyroidismis a prevalent condition affecting global populations, with an overall prevalence of 1.2%. Our research aimed to establish a systematic diagnostic approach using multiparametric ultrasound (MPUS) to diagnose hyperthyroid diffuse thyroid disease (DTD).MethodsWe conducted a retrospective study from June 2021 to June 2023 at a specialized endocrinology center in Timisoara, Romania, enrolling subjects presenting with clinical hyperthyroidism. Using the Mach 30 Aixplorer ultrasound equipment, evaluations were performed initially in B-mode US, followed by Color Doppler and Spectral Doppler measurements, and finally, 2D Shear wave elastography (SWE).ResultsFrom the 218 patients analyzed, the diagnosis of DTD with hyperthyroidism was confirmed through biochemical assessment, subgrouping various pathologies such as subacute thyroiditis, Graves’ disease, painless thyroiditis, Hashimoto’s thyroiditis, iatrogenic, as well as healthy controls. In the first step, B-mode hypoechogenicity had an AUC of 0.951 for DTD detection. In the second step, the peak systolic velocity differentiated Graves’ disease with a median of 42.4 cm/s and an AUC of 1. Lastly, the third step consisted of SWE evaluation, revealing a mean elasticity index in the SAT subgroup significantly higher from other subgroups (p<0.001) with an AUC of 1.ConclusionOur study offers a step-by-step evaluation algorithm for DTD diagnosis, with a very good overall diagnostic performance (AUC of 0.946).

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Shear wave elastography as a quantitative method for thyroid gland elasticity assessment in pediatrics patients with autoimmune-related thyroid disease, diagnostic utility and laboratory correlation

Cited by 3 publications

References 21 publications

A Comparative Analysis of Strain and 2D Shear Wave Elastography in the Diagnosis of Autoimmune Thyroiditis in Pediatric Patients

A Comparative Analysis of Strain and 2D Shear Wave Elastography in the Diagnosis of Autoimmune Thyroiditis in Pediatric Patients

Can Shear Wave Elastography Help Differentiate Acute Tonsillitis from Normal Tonsils in Pediatric Patients: A Prospective Preliminary Study

Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease

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