Shear wave elastography as a new method to identify parotid lymphoma in primary Sjögren Syndrome patients: an observational study

Badarinza, Maria; Şerban, Oana; Maghear, Lavinia; Bocşa, Corina; Micu, Mihaela; Damian, Laura; Felea, Ioana; Fodor, Daniela

doi:10.1007/s00296-020-04548-x

Cited by 25 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Normally, the salivary tissue does not contain any lymphocytes, thus states of chronic inflammation are responsible for lymphoid proliferation and the development of MALT lymphoma [5]. An increased incidence of parotid lymphoma was reported in patients with underlying autoimmune conditions (Sjögren's Syndrome) or chronic infections [6,7]. Our patient's medical history was, however, negative for the above-mentioned pathologies.…”

Section: Discussionmentioning

confidence: 67%

Mucosa-associated lymphoid tissue lymphoma of the parotid gland – a case report

Muntean¹,

Dudea

Lenghel

et al. 2021

Med Ultrason

View full text Add to dashboard Cite

Mucosa-associated lymphoid tissue (MALT) lymphoma of the parotid gland is a rare entity among head and neck tumours. We report a case of a patient with a medical history of diffuse large B-cell Non-Hodgkin Lymphoma with complete remission following chemotherapy, who presented seven years afterwards with a progressive painless hard swelling of the right parotidgland. Ultrasonography followed by contrast-enhanced MRI features was consistent with a malignant tumour. Consequently, fine and core needle aspiration biopsy were performed under ultrasound guidance and the final histopathological result was MALT lymphoma of the parotid gland. The most important particularity of the case is the sequential development of two different histopathological types of Non-Hodgkin Lymphoma, both of B-cell lineage.

show abstract

Section: Discussionmentioning

confidence: 67%

Mucosa-associated lymphoid tissue lymphoma of the parotid gland – a case report

Muntean¹,

Dudea

Lenghel

et al. 2021

Med Ultrason

View full text Add to dashboard Cite

show abstract

“… 37 In addition to determining the mass properties in salivary glands and early diagnosis of parotid non-Hodgkin lymphoma, SWE was also applied to assessing the chronic inflammation of major salivary glands. 20 , 21 , 35 , 38 , 39 Bădărînză et al . 20 showed the SWE values of PGs have high specificity of 99.9% in distinguishing pSS patients without lymphoma from those with parotid lymphoma development, but the specificity in distinguishing pSS patients from healthy subjects was only 80%.…”

Section: Discussionmentioning

confidence: 99%

“…This interesting finding may explain the low distinguishing value of SWE examination between SS patients and healthy controls. 20 , 39 We conducted a biopsy in one PG with a US score of 4 and found the histological change of multiple hyperechoic areas was adipose tissue, suggesting that replacement of adipose tissue may lead to the low stiffness of salivary glands, although it needs to be further validated in large sample studies. Furthermore, the PPV in patients with the total SWE values ⩾33 kPa was 100% for predicting positive LSGB, which extends the application of the SWE examination in major salivary glands, although the NPV is low if only based on the total SWE values.…”

Section: Discussionmentioning

confidence: 99%

“… 19 SWE can quantitatively detect the stiffness of major salivary glands owing to a system’s quantification tool, so it is used not only for early diagnosis, biopsy guidance and treatment monitoring of the parotid non-Hodgkin lymphoma, but also increasing the diagnostic rate of pSS from 88.6% to 94.2% in patients with normal or non-specific B-mode US. 20 , 21 …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasonography predicts the results of labial salivary gland biopsy in patients with suspected Sjögren’s syndrome: a matrix risk model

Hao

et al. 2021

Therapeutic Advances in Musculoskeletal

View full text Add to dashboard Cite

Objective: Although a positive result of labial salivary gland biopsy (LSGB) is critical for the diagnosis of Sjögren’s syndrome, rheumatologists prefer assessing the non-invasive objective items and hope to learn the predicted probability of positive LSGB before referring patients with suspected Sjögren’s syndrome to receive biopsy. This study aimed to explore the predictive value of combined B-mode ultrasonography (US) and shear-wave elastography (SWE) examination on LSGB results. Methods: A derivation cohort and later a validation cohort of patients with suspected Sjögren’s syndrome were recruited. All participants received clinical assessments, B-mode US and SWE examination on bilateral parotid and submandibular glands before LSGB. Positive LSGB was defined by a focus score ⩾1 per 4 mm2 of glandular tissue. Results: In the derivation cohort of 91 participants, either the total US scores or the total SWE values of four glands significantly distinguished patients with positive LSGB from those with negative results (area under the curve (AUC) = 0.956, 0.825, both p < 0.001). The positive predictive value (PPV) was 100% in patients with total US scores ⩾9 or with total SWE values ⩾33 kPa. The negative predictive value (NPV) was 100% in patients with total US scores <5, but 68% in patients with total SWE values <27 kPa. A matrix risk model was derived based on the combination of total US scores and total SWE values. Patients can be stratified into high, moderate, and low risk of positive LSGB. In the validation cohort of 52 participants, the PPV was 94% in the high-risk subpopulation and the NPV was 93% in the low-risk subpopulation. Conclusion: A novel matrix risk model based on the combined B-mode US and SWE examination can help rheumatologists to make a shared decision with suspected Sjögren’s syndrome patients on whether the invasive procedure of LSGB should be performed.

show abstract

“…The value of SWE is considered for US pSS diagnosis in cases where the GSUS findings were normal or nonspecific. 2D-SWE of the parotid glands should be considered as a promising imaging technique for detection of parotid lymphoma complication in pSS patients (110). Different authors also showed that SWE was capable to detect changes radiation induced in the elasticity of parotid glands between a radiotherapy group and a reference group (128,129).…”

Section: Discussionmentioning

confidence: 99%

Narrative review of multiparametric ultrasound in parotid gland evaluation

Martino¹,

Fodor²,

Fresilli³

et al. 2020

Gland Surg

Self Cite

View full text Add to dashboard Cite

Disorders affecting parotid gland represent a heterogeneous group comprising congenital, inflammatory and neoplastic diseases which show a focal or diffuse pattern of appearance. The differentiation of neoplastic from non-neoplastic conditions of parotid glands is pivotal for the diagnostic imaging. Frequently there is evidence of overlapping between the clinical and the imaging appearance of the various pathologies. The parotid gland is also often object of study with the combination of different techniques [ultrasound-computed tomography-magnetic resonance imaging (US-CT-MRI), ex.]. Compared to other dominant methods of medical imaging, US has several advantages providing images in real-time at lower cost, and without harmful use of ionizing radiation and of contrast enhancement. B-mode US, and the microvascular pattern color Doppler are usually used as first step evaluation of parotid lesions. Elastography and contrast-enhanced US (CEUS) has opened further possible perspectives to improve the differentiationbetween benign and malignant parotid lesions. The characterization of the parotid tumors plays a crucial role for their treatment planning and for the prediction of possible surgical complications. We present, here an updated review of the most recurrent pathologies of parotid gland focusing on the diagnostic power of multiparametric US including CEUS and ultrasound elastography (USE); limitations, advantages and the main key-points will be presented

show abstract

Shear wave elastography as a new method to identify parotid lymphoma in primary Sjögren Syndrome patients: an observational study

Cited by 25 publications

References 28 publications

Mucosa-associated lymphoid tissue lymphoma of the parotid gland – a case report

Mucosa-associated lymphoid tissue lymphoma of the parotid gland – a case report

Ultrasonography predicts the results of labial salivary gland biopsy in patients with suspected Sjögren’s syndrome: a matrix risk model

Narrative review of multiparametric ultrasound in parotid gland evaluation

Contact Info

Product

Resources

About