Shear-Wave Dispersion Slope from US Shear-Wave Elastography:                    Detection of Allograft Damage after Liver Transplantation

Lee, Dong Hoon; Lee, Jae Young; Bae, Jae Seok; Yi, Nam Joon; Lee, Kwang Woong; Suh, Kyung Suk; Kim, Haeryoung; Lee, Kyuho; Han, Joon Koo

doi:10.1148/radiol.2019190064

Cited by 71 publications

(79 citation statements)

References 25 publications

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“…A significantly higher mean Vi PLUS value was found in COVID-19 patients with pulmonary injury (1.74 ± 0.28 vs. 1.64 ± 0.25, p < 0.0009) in our study. While inflammation plays a pivotal role in the development and progression of liver fibrosis, the non-invasive assessment of inflammation has been studied in past years, with promising results [ 32 , 33 , 34 , 35 , 36 , 37 ]. Several preliminary studies have shown that viscosity might be a useful parameter in tissue characterization, and it might help to detect necroinflammation in the liver [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

A Multidisciplinary Approach to Evaluate the Presence of Hepatic and Cardiac Abnormalities in Patients with Post-Acute COVID-19 Syndrome—A Pilot Study

Bende

Tudoran

Sporea

et al. 2021

JCM

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(1) Background: Patients suffering from the novel coronavirus 2019 (COVID-19) disease could experience several extra-pulmonary involvements, including cardiovascular complications and liver injury. This study aims to evaluate the presence of cardiac and liver alterations in patients with post-acute COVID-19 syndrome using transthoracic echocardiography (TTE) and liver elastography (LE). (2) Methods: A total of 97 subjects recovering from COVID-19, attending the hospital’s specialized outpatient clinic for persisting symptoms at 3 to 11 weeks after the acute illness, were included in this study. They all had a basal COVID-19 assessment, and subsequently, a clinical evaluation, laboratory tests, TTE, and LE. (3) Results: considering the presence of pulmonary injury during COVID-19, patients were divided into two groups. Although none of them had altered systolic function, we evidenced pulmonary hypertension, diastolic dysfunction, increased liver stiffness, viscosity, and steatosis in around one-third of the patients, with significantly higher values in subjects with pulmonary injury compared to those without. (4) Conclusion: persisting symptoms characterizing the post-acute COVID-19 syndrome could be explained by residual cardiac and hepatic lesions, which were worse in more severe COVID-19 forms. These patients may be at risk of developing liver fibrosis and cardiac alterations and should be investigated in the first 12 weeks after the onset of the infection.

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Section: Discussionmentioning

confidence: 99%

A Multidisciplinary Approach to Evaluate the Presence of Hepatic and Cardiac Abnormalities in Patients with Post-Acute COVID-19 Syndrome—A Pilot Study

Bende

Tudoran

Sporea

et al. 2021

JCM

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“…Using the fast Fourier transform algorithm, each displacement caused by shear waves can be transformed from the time domain to the frequency domain. Finally, from shear wave speed and frequency, SWD can be estimated as a phase domain, and is calculated in units of (m/sec)/kHz [8,11]. Since 2D-SWI was introduced, several preliminary studies have reported the clinical significance of SWD in various hepatic diseases, both in a rat model and in human patients [8,11,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, using a rat model, shear wave speed was found to be strongly correlated with lobular inflammation of the liver, whereas dispersion was significantly associated with tissue necrosis [8]. Recently, a few preliminary studies have provided support for the correlation between necroinflammation and dispersion in human liver tissue [11]. However, to our knowledge, no studies have been published or preliminary results reported about both stiffness and dispersion, except in liver cirrhosis or steatohepatitis.…”

Section: Introductionmentioning

confidence: 90%

Added value of 2D shear wave imaging of the gallbladder bed of the liver for acute cholecystitis

Lee

Park

et al. 2020

Ultrasonography

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Epub ahead of printPurpose: The purpose of this study was to evaluate whether shear wave elastography (SWE) and the shear wave dispersion slope (SWD) obtained from 2-dimensional shear wave imaging (2D-SWI) of the gallbladder (GB) bed of the liver could be helpful in the diagnosis of acute cholecystitis. Methods: We included 44 patients referred for abdominal ultrasonography (US) under the impression of acute cholecystitis from April 2018 to March 2019. Patients with chronic liver disease were excluded from this study. In addition to routine upper abdominal US, we performed 2D-SWI including liver stiffness measurements by SWE and SWD, which reflects tissue viscosity. 2D-SWI was performed at the GB bed of the liver through the right intercostal approach at least 3 times with different frames. We assessed typical US findings and the added value of 2D-SWI in diagnosing acute cholecystitis. Histopathologic results of surgical specimens were used as the standard of reference. If a surgical specimen was unavailable, a bile fluid test or clinical followup for more than 3 months served as the reference standard. Results: The optimal cutoff values for SWE and SWD were 8 kPa and 10.9 (m/sec)/kHz, respectively. In the univariate analysis, SWE, GB distension, and sludge were predictive factors of acute cholecystitis. In the multivariate analysis, categorized SWE was the only significant predictor (P<0.01). By using 2D-SWI, the diagnostic performance of two readers did not significantly increase, although the inter-reader agreement improved (k=0.654-0.778). Conclusion: 2D-SWI of the GB bed of the liver could be helpful for diagnosing acute cholecystitis.

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“…Although SWE reflects both elasticity and viscosity (i.e., viscoelasticity) [22]. SWD is calculated based on SWD measurements and reflects viscosity only [24,25]. Since liver fibrosis advances gradually as hepatitis progresses [26], SWD may be able to estimate liver damage in an earlier stage than SWE.…”

Section: Introductionmentioning

confidence: 99%

Shear Wave Dispersion Predicts Liver Fibrosis and Adverse Outcomes in Patients with Heart Failure

Ohara

Yoshihisa

Ishibashi

et al. 2020

JCM

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Background: It has been recently reported that liver stiffness assessed by transient elastography reflects right atrial pressure (RAP) and is associated with worse outcomes in patients with heart failure (HF). However, the relationship between shear wave dispersion (SWD, a novel indicator of liver viscosity) determined by abdominal ultrasonography and RAP, and the prognostic impact of SWD on HF patients have not been fully examined. We aimed to clarify the associations of SWD with parameters of liver function test (LFT) and right heart catheterization (RHC), as well as with cardiac events such as cardiac death and worsening HF, in patients with HF. Methods: We performed abdominal ultrasonography, LFT and RHC in HF patients (n = 195), and followed up for cardiac events. We examined associations between SWD and parameters of LFT and RHC. Results: There were significant correlations between SWD and circulating levels of direct bilirubin (R = 0.222, p = 0.002), alkaline phosphatase (R = 0.219, p = 0.002), cholinesterase (R = −0.184, p = 0.011), and 7S domain of collagen type IV (R = 0.177, p = 0.014), but not with RAP (R = 0.054, p = 0.567) or cardiac index (R = −0.015, p = 0.872). In the Kaplan–Meier analysis, cardiac event rate was significantly higher in the high SWD group (SWD ≥ 10.0 (m/s)/kHz, n = 103) than in the low SWD group (SWD < 10.0 (m/s)/kHz, n = 92; log-rank, p = 0.010). In the Cox proportional hazard analysis, high SWD was associated with high cardiac event rates (hazard ratio, 2.841; 95% confidence interval, 1.234–6.541, p = 0.014). In addition, there were no interactions between SWD and all subgroups, according to the subgroup analysis. Conclusions: SWD assessed by abdominal ultrasonography reflects liver fibrosis rather than liver congestion, and is associated with adverse prognosis in HF patients.

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Shear-Wave Dispersion Slope from US Shear-Wave Elastography: Detection of Allograft Damage after Liver Transplantation

Cited by 71 publications

References 25 publications

A Multidisciplinary Approach to Evaluate the Presence of Hepatic and Cardiac Abnormalities in Patients with Post-Acute COVID-19 Syndrome—A Pilot Study

A Multidisciplinary Approach to Evaluate the Presence of Hepatic and Cardiac Abnormalities in Patients with Post-Acute COVID-19 Syndrome—A Pilot Study

Added value of 2D shear wave imaging of the gallbladder bed of the liver for acute cholecystitis

Shear Wave Dispersion Predicts Liver Fibrosis and Adverse Outcomes in Patients with Heart Failure

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