Shear Wave Dispersion Measures Liver Steatosis

Barry, Christopher T.; Mills, Bradley N.; Hah, Zaegyoo; Mooney, Robert A.; Ryan, Charlotte; Rubens, Deborah J.; Parker, Kevin J.

doi:10.1016/j.ultrasmedbio.2011.10.019

Cited by 130 publications

(107 citation statements)

References 45 publications

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“…A recent study of excised mouse livers showed that liver steatosis correlates with shear wave dispersion (a property related to tissue viscosity) but not liver elasticity (16), which implies that viscosity may provide independent information about tissue state in addition to elasticity. An MR elastography study in 88 patients (14) showed that both elasticity and viscosity correlate with liver fibrosis stage; however, viscosity had less predictive value than elasticity.…”

Section: Methodsmentioning

confidence: 99%

“…Measurements of liver tissue elasticity were obtained by six sonographers (with 8,11,11,15,16, and 25 years of experience) in the right lobe of the liver by using a curvilinear transducer (C5-1, Philips Healthcare) through intercostal spaces with the subject lying supine with right arm abduction. The operator positioned the probe by using real-time B-mode imaging to locate a large liver area free of major vessels.…”

Section: Us Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force

Chen

Sánchez²,

Callstrom³

et al. 2013

Radiology

225

142

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MS Purpose:To investigate the value of viscosity measured with ultrasonographic (US) elastography in liver fibrosis staging and to determine whether the use of a viscoelastic model to estimate liver elasticity can improve its accuracy in fibrosis staging. Materials and Methods:The study, which was performed from February 2010 to March 2011, was compliant with HIPAA and approved by the institutional review board. Written informed consent was obtained from each subject. Ten healthy volunteers (eight women and two men aged 27-55 years) and 35 patients with liver disease (17 women and 18 men aged 19-74 years) were studied by using US elasticity measurements of the liver (within 6 months of liver biopsy). US data were analyzed with the shear wave dispersion ultrasound vibrometry (SDUV) method, in which elasticity and viscosity are measured by evaluating dispersion of shear wave propagation speed, as well as with the time-to-peak (TTP) method, where tissue viscosity was neglected and only elasticity was estimated from the effective shear wave speed. The hepatic fibrosis stage was assessed histologically by using the METAVIR scoring system. The correlation of elasticity and viscosity was assessed with the Pearson correlation coefficient. The performances of SDUV and TTP were evaluated with receiver operating characteristic (ROC) curve analysis. Results:The Conclusion:The results suggest that elasticity and viscosity measured between 95 Hz and 380 Hz by using SDUV are correlated and that elasticity measurements from SDUV and TTP showed substantially similar performance in liver fibrosis staging, although elasticity calculated from SDUV provided a better area under the ROC curve.q RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup /suppl

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Section: Methodsmentioning

confidence: 99%

Section: Us Measurementsmentioning

confidence: 99%

Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force

Chen

Sánchez²,

Callstrom³

et al. 2013

Radiology

225

142

View full text Add to dashboard Cite

show abstract

“…Huwart et al (2007) studied 88 patients by MR elastography and concluded that the elasticity appeared to be a more discriminant marker for liver fibrosis staging. Barry et al (2012) showed that viscosity may be associated more closely with another tissue pathological state-liver steatosis, which is an accumulation of fat in the liver. In this study, Barry concluded that increasing the amounts of fat evidently increased the liver viscosity, which resulted in increased dispersion of shear wave speed and attenuation.…”

Section: Discussionmentioning

confidence: 99%

Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli

Zhu

Zheng

Shen

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:The process of liver fibrosis changes the rheological properties of liver tissue. This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli. Here two viscoelastic models, the Zener model and Voigt model, were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage. The results demonstrate that moderate fibrosis (≤F2) has a good correlation with liver viscoelasticity. The mean Zener elasticity E 1 increases from (0.452±0.094) kPa (F0) to (1.311±0.717) kPa (F2), while the mean Voigt elasticity E increases from (0.618±0.089) kPa (F0) to (1.701±0.844) kPa (F2). The mean Zener viscosity increases from (3.499±0.186) Pa·s (F0) to (4.947±1.811) Pa·s (F2) and the mean Voigt viscosity increases from (3.379±0.316) Pa·s (F0) to (4.625±1.296) Pa·s (F2). Compared with viscosity, the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used. Therefore, the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.

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“…ARFI parameters, shear wave velocity, and attenuation are strongly correlated with the degree of HS in animal studies [33], [34]. With human samples, studies have shown that HS has no statistical influence [35] or correlation [32] with ARFI results, in contrast to Fibroscan [32], [35], [36].…”

Section: Discussionmentioning

confidence: 99%

An Ultrasound-Based Computer-Aided Diagnosis Tool for Steatosis Detection

Ribeiro

Marinho

Sanches

2014

IEEE J. Biomed. Health Inform.

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Abstract-Liver steatosis is a common disease usually associated with social and genetic factors. Early detection and quantification is important since it can evolve to cirrhosis. In this paper, a new computer-aided diagnosis (CAD) system for steatosis classification, in a local and global basis, is presented. A Bayes factor is computed from objective ultrasound textural features extracted from the liver parenchyma. The goal is to develop a CAD screening tool to help in the steatosis detection. Results showed an accuracy of 93.33%, with a sensitivity of 94.59% and specificity of 92.11%, using the Bayes classifier. The proposed CAD system is a suitable graphical display for steatosis classification.

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Shear Wave Dispersion Measures Liver Steatosis

Cited by 130 publications

References 45 publications

Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force

Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force

Analyzing and modeling rheological behavior of liver fibrosis in rats using shear viscoelastic moduli

An Ultrasound-Based Computer-Aided Diagnosis Tool for Steatosis Detection

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