Shear-Thinning Viscous Materials for Subconjunctival Injection of Microparticles

Xia, Shiyu; Ding, Zheng; Luo, Lixia; Chen, Baiwei; Schneider, Joanna; Yang, Jin; Eberhart, Charles G.; Stark, Walter J.; Xu, Qingguo

doi:10.1208/s12249-020-01877-9

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…The particles were entrapped in the HA and MC mesh-like network as this polymer has sufficient viscosity for retention of microparticles for a prolonged period. The physical adhesion or attachment to the conjunctiva may also extend the release of drugs [133]. A similar study was done by Nagai et al; in this study, an in-situ gel was prepared by assimilating TL-NPs and the methylcellulose (0.5-3%) to get the prolonged residence time of the drug.…”

Section: Cellulosic Polymers In Ocular Drug Deliverymentioning

confidence: 71%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

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Section: Cellulosic Polymers In Ocular Drug Deliverymentioning

confidence: 71%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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“…Moreover, the blended polymers could prevent microparticle leakage through the needle puncture at the site of injection by up to 80% for 30 days, and drug release lasted over 3 weeks. According to the authors, this system represents a promising direction for successful injections of microparticles without formulation loss or needle clogging [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

The Use of Polymer Blends in the Treatment of Ocular Diseases

et al. 2022

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The eye is an organ with limited drug access due to its anatomical and physiological barriers, and the usual forms of ocular administration are limited in terms of drug penetration, residence time, and bioavailability, as well as low patient compliance. Hence, therapeutic innovations in new drug delivery systems (DDS) have been widely explored since they show numerous advantages over conventional methods, besides delivering the content to the eye without interfering with its normal functioning. Polymers are usually used in DDS and many of them are applicable to ophthalmic use, especially biodegradable ones. Even so, it can be a hard task to find a singular polymer with all the desirable properties to deliver the best performance, and combining two or more polymers in a blend has proven to be more convenient, efficient, and cost-effective. This review was carried out to assess the use of polymer blends as DDS. The search conducted in the databases of Pubmed and Scopus for specific terms revealed that although the physical combination of polymers is largely applied, the term polymer blend still has low compliance.

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“…For injectable formulations, the thermogelling formulations must have a low enough viscosity at the injection temperature to allow for flow through a fine gauge needle (26-31 G). [53,54] The time in which the formulation undergoes transition to the gel state is also important to not clog the needle during injection. Finally, application localized to the inferior fornix allows for formulations to have a greater solution viscosity.…”

Section: Advancements For Anterior Applicationmentioning

confidence: 99%

Application of Thermogels to the Anterior of the Eye as Alternatives to Conventional Eyedrops

Ross

Sheardown

2023

Advanced Therapeutics

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The anterior of the eye can be affected by numerous different diseases, but the treatment of these diseases is dominated by topical formulations which are well documented to be largely ineffective. To increase the efficacy of these drugs, thermogel formulations have been developed for sustained release following application to the anterior of the eye. These thermogel formulations have been designed for either injectable or topical application. The types of polymers used to create the thermogels, testing methods, and subsequent performance will be outlined in this review. The current trends in design including increasing mechanical performance, utilizing designed degradation, incorporation of micro or nanoparticles, and developing mucoadhesion formulations are also highlighted.

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Shear-Thinning Viscous Materials for Subconjunctival Injection of Microparticles

Cited by 7 publications

References 32 publications

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

The Use of Polymer Blends in the Treatment of Ocular Diseases

Application of Thermogels to the Anterior of the Eye as Alternatives to Conventional Eyedrops

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