Shear stress regulated uptake of liposome-decorated microgels coated with a poly(dopamine) shell

York-Durán, María José; Ek, Pramod Kumar; Godoy-Gallardo, María; Hosta‐Rigau, Leticia

doi:10.1016/j.colsurfb.2018.07.031

Cited by 10 publications

(21 citation statements)

References 29 publications

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“…To avoid Hb's leakage from the particles, we employed a PDA coating by the self‐polymerization of dopamine (DA) in basic conditions . PDA has scarcely any chemical reaction with Hb's functional groups while also allowing for post‐functionalization (e.g., PEGylation) by its ability to react via Schiff base and/or Michael addition with thiols and amines . Furthermore, PDA can also offer antioxidant protection thus minimizing the conversion of Hb into nonfunctional metHb …”

Section: Resultsmentioning

confidence: 99%

“…PLL(15–30 kDa)‐ graft [2.0]‐poly(ethylene glycol (2 kDa)) (PLL‐ g ‐PEG) was synthetized following a reported procedure . Briefly, a solution containing 0.038 mmol Me‐PEG‐NHS (with respect to the polymer's molecular weight) in cold HEPES was added to a solution containing 0.143 mmol PLL (with respect to the repeating unit) in chilled HEPES.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Liu

Jansman

Thulstrup

et al. 2019

Macromolecular Bioscience

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10. 1002/mabi.201900293. Despite all the attempts to create advanced hemoglobin (Hb)-based oxygen carriers (HBOCs) employing an encapsulation platform, major challenges including attaining a high Hb loading and long circulation times still need to be overcome. Herein, the fabrication, for the first time, of nanoparticles fully made of Hb (Hb-NPs) employing the electrospray technique is reported. The Hb-NPs are then coated by antioxidant and self-polymerized poly(dopamine) (PDA) to minimize the conversion of Hb into nonfunctional methemoglobin (metHb). The PDA shell is further functionalized with poly(ethylene glycol) (PEG) to achieve stealth properties. The results demonstrate that the asprepared Hb-NPs are hemo-and biocompatible while offering antioxidant protection and decreasing the formation of metHb. Additionally, decoration with PEG results in decreased protein adsorption onto the Hb-NPs surface, suggesting a prolonged retention time within the body. Finally, the Hb-NPs also preserve the reversible oxygen-binding and releasing properties of Hb. All in all, within this study, a novel HBOCs with high Hb content is fabricated and its potential as an artificial blood substitute is evaluated.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Liu

Jansman

Thulstrup

et al. 2019

Macromolecular Bioscience

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“…27 We have recently reported a variation of this hybrid platform where poly(N-isopropylacrylamide-co-acrylic acid) (p(NIPAAMco-AAc)) microgels (MGs) were decorated with liposomes and subsequently coated by a protective poly(dopamine) shell (PDA). 28 Such a system was evaluated in the context of codelivery for therapeutic compounds. While p(NIPAM-co-AAc) MGs exhibit a fast release profile due to their large pore sizes, 28 liposomes were chosen as the second type of compartments to attain a slower release profile.…”

Section: Introductionmentioning

confidence: 99%

“…28 Such a system was evaluated in the context of codelivery for therapeutic compounds. While p(NIPAM-co-AAc) MGs exhibit a fast release profile due to their large pore sizes, 28 liposomes were chosen as the second type of compartments to attain a slower release profile. Next, PDA, the self-assembly product of dopamine (DA) which easily attaches homogeneously onto almost all kinds of substrates with controllable film thickness, was used as a coating to enhance liposomes stability.…”

Section: Introductionmentioning

confidence: 99%

“…Next, PDA, the self-assembly product of dopamine (DA) which easily attaches homogeneously onto almost all kinds of substrates with controllable film thickness, was used as a coating to enhance liposomes stability. 28,29 Interestingly, PDA as the most common synthetic melanin analogue, possesses excellent antioxidant ability. 30 Herein with the aim to advance our dual-component platform, we explore its potential as a microreactor for ROS depletion by making use of PDA's antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

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A dual-component carrier with both non-enzymatic and enzymatic antioxidant activity towards ROS depletion

et al. 2019

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Recent Developments in Nanomaterial‐Based Shear‐Sensitive Drug Delivery Systems

Wang

Pisapati

Zhang

et al. 2021

Adv Healthcare Materials

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Nanomaterial‐based drug delivery systems (DDSs) increase the efficacy of various therapeutics, and shear stress has been shown to be a robust modulator of payload release. In the past few decades, a deeper understanding has been gained of the effects of flow in the body and its alteration in pathological microenvironments. More recently, shear‐responsive nanomaterial DDSs have been developed. Studies on this subject mainly from the last decade are reviewed here, focusing on innovations of the material design and mechanisms of the shear response. The two most popular shear‐controlled drug carriers distinguished by different release mechanisms, that is, shear‐deformable nanoparticles (NPs) and shear‐dissociated NP aggregates (NPAs), are surveyed. The influence of material structures on their properties such as drug loading, circulation time, and shear sensitivity are discussed. The drug development stages, therapeutic effects, limitations, and potential of these DDSs are further inspected. The reviewed research emphasizes the advantages and significance of nanomaterial‐based shear‐sensitive DDSs in the field of targeted drug delivery. It is also believed that efforts to rationally design nanomaterial DDSs responsive to shear may prompt a new class of diagnostics and therapeutics for signaling and rectifying pathological flows in the body.

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Shear stress regulated uptake of liposome-decorated microgels coated with a poly(dopamine) shell

Cited by 10 publications

References 29 publications

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

Low‐Fouling Electrosprayed Hemoglobin Nanoparticles with Antioxidant Protection as Promising Oxygen Carriers

A dual-component carrier with both non-enzymatic and enzymatic antioxidant activity towards ROS depletion

Recent Developments in Nanomaterial‐Based Shear‐Sensitive Drug Delivery Systems

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