Shear stress and very low levels of ligand synergize to activate ALK1 signaling in endothelial cells
Ya-Wen Cheng,
Anthony R. Anzell,
Tristin A. Schwartze
et al.
Abstract:Endothelial cells (ECs) respond to concurrent stimulation by biochemical fac-tors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed mechanisms linking flow-mechanical cues and biochemical signaling remain unclear. Activin receptor-like kinase 1 (ALK1) integrates SS and ALK1-ligand cues in ECs; ALK1 mutations cause hereditary hemorrhagic telangiectasia (HHT), marked by arteriovenous malformation (… Show more
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