Abstract:Platelet activation by mechanical means such as shear stress, is a vital driver of thrombotic risk in implantable blood-contacting devices used in treatment of heart failure. Lipids are essential in platelets activation and have been studied following biochemical activation. However, little is known regarding lipid alterations occurring with mechanical – shear mediated platelet activation. Here, we determined if shear-activation of platelets induced lipidome changes that differ from those associated with bioch… Show more
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