As bridge deck slabs experience the direct impact of repeated concentrated wheel loads, they are more susceptible to fatigue‐related damage than other bridge components. In this context, a fatigue life prediction method for reinforced concrete (RC) bridge decks has been developed based on failure mechanisms of RC slabs tested under moving wheel loads. Initially, the formulas encompassed shear strength and S–N equations, accommodating variations in environmental and support conditions, are proposed to facilitate the fatigue life prediction of slabs exposed to constant moving wheel load. Subsequently, a model for shear strength degradation formulated using experimental findings on beam‐like elements is utilized in predicting the fatigue life of slabs subjected to stepwise moving wheel loads. The validity of the proposed method was established by comparing its results with previous experimental data. Notably, compared with the existing prediction equation, the proposed method exhibited more accurate fatigue life prediction results.