Sheabutter V: Effect of Particle Size on Release of Medicament from Ointment

Konning, G.H.; Mital, H. C.

doi:10.1002/jps.2600670327

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…Unrefined, it has anti-inflammatory activity revealed by traditional medicine (1,2) and confirmed by various scientific works (3)(4)(5)(6)(7). In addition, it can be used as an excipient for various conventional dosage forms such as ointments and creams (8)(9)(10)(11)(12)(13) but also as a base material for the preparation of drug carriers (14).…”

Section: Introductionmentioning

confidence: 95%

Contribution of Nanotechnology In the Improvement of the Anti-Inflammatory activity of Shea butter.

Thioune¹,

Dieng²,

Fall³

et al. 2019

AJPTR

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Unrefined shea butter is a vegetable fat that can be used for its anti-inflammatory properties related to its unsaponifiable fraction but also as excipient for various forms. In this study, the aim was to see how to take advantage of this dual status in order to improve the anti-inflammatory activity of shea butter through nanotechnology. In other words, it was to test the hypothesis of an improvement of the anti-inflammatory activity of unrefined shea butter when used in the form of nanoparticles and gel / nanoparticle system. The nanoparticles were prepared by a phase inversion method and had an average size of 400 nm with a poly dispersion index of 0.416, a zeta potential between -5 and -7mV and a pH around 5.3-5.4. The gel / nanoparticle complex was obtained by mixing the nanoparticles with a gel based on polyethylene glycol, water and HydroxyPropyl Methylcellulose. The mouse ear edema test was implemented for the evaluation of the antiinflammatory activity and the results showed a clear improvement of the latter. Indeed, the ratios (R) between the percentage inhibition of the anti-inflammatory activity (I) and the real percentage of shea butter used in the various preparations are respectively: crude shea butter (I = 62.52%; R = 0.62), nanoparticles (I = 60.80%, R = 1.05) and gel / nanoparticle complex system (I = 52.41, R = 6.38) (for the latter, the proportion of nanoparticles in the complex system was 4/24).

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Section: Introductionmentioning

confidence: 95%

Contribution of Nanotechnology In the Improvement of the Anti-Inflammatory activity of Shea butter.

Thioune¹,

Dieng²,

Fall³

et al. 2019

AJPTR

View full text Add to dashboard Cite

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“…A solvent extraction method has also been used to determine the particle size of drug substance in ointment products. One report [20] applied solvent to recover the drug crystals from the finished ointment product and then microscopy was used to measure the particle size of the drug crystals. However, caution should be taken when using this pretreatment method since the size and size distribution of the API may change during the extraction process, as a result of any one or combination of aggregation, dissolution and degradation of the API, leading to erroneous data.…”

Section: Particle Size and Particle Size Distribution Of Api In The Fmentioning

confidence: 99%

Perspectives on Physicochemical and In Vitro Profiling of Ophthalmic Ointments

Bao

Burgess

2018

Pharm Res

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Ophthalmic ointments are unique in that they combine features of topical drug delivery, the ophthalmic route and ointment (semisolid) formulations. Accordingly, these complex formulations are challenging to develop and evaluate and therefore it is critically important to understand their physicochemical properties as well as their in vitro drug release characteristics. Previous reports on the characterization of ophthalmic ointments are very limited. Although there are FDA guidance documents and USP monographs covering some aspects of semisolid formulations, there are no FDA guidance documents nor any USP monographs for ophthalmic ointments. This review summarizes the physicochemical and in vitro profiling methods that have been previously reported for ophthalmic ointments. Specifically, insight is provided into physicochemical characterization (rheological parameters, drug content and content uniformity, and particle size of the API in the finished ointments) as well as important considerations (membranes, release media, method comparison, release kinetics and discriminatory ability) in in vitro drug release testing (IVRT) method development for ophthalmic ointments.

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“…But apart from its therapeutic properties, shea butter has other potentialities that have interested researchers. Indeed, its excipient properties have been the subject of numerous works, some of which date back several decades (23)(24)(25)(26). Subsequent studies have confirmed such properties (27,28).…”

Section: Introductionmentioning

confidence: 99%

Focus On the Use of Shea Butter as Excipient For Ointment

Thioune¹,

Fall²,

Dieng³

et al. 2019

AJPTR

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Shea butter is a fat produced from the seeds of Vitellaria paradoxa (Sapotaceae). It can exist under different qualities which depend on several factors such as the region of origin, the method of production, treatments performed, etc. Its use as ointment excipient was the subject of several work that has raised issues that need further discussion. In this study, certain aspects relating to the adequacy between the main properties required for the ointment excipients and the characteristics of the different qualities of shea butter were analyzed. The data collected showed that for some properties, namely organoleptic characteristics such as color and odor, it may be necessary to perform discoloration or deodorization operations to ensure the comfort of the user. Similarly, it has sometimes been necessary to add peanut oil to the butter to reduce its consistency in order to facilitate its spreading. Concerning the release of the active ingredients, the qualities of the butter seem to have no influence because whatever the butter used, the results obtained were satisfactory.As regards inertia and long-term stability, the composition could have a great influence, but the refined shea butter obtained by chemical extraction seems more apt to act as an excipient.However, for such a product, it is still necessary to standardize industrial procedures for obtaining it, with a view to propose a standard shea butter, specifically for use as ointment excipient.

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Sheabutter V: Effect of Particle Size on Release of Medicament from Ointment

Cited by 10 publications

References 5 publications

Contribution of Nanotechnology In the Improvement of the Anti-Inflammatory activity of Shea butter.

Contribution of Nanotechnology In the Improvement of the Anti-Inflammatory activity of Shea butter.

Perspectives on Physicochemical and In Vitro Profiling of Ophthalmic Ointments

Focus On the Use of Shea Butter as Excipient For Ointment

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