She’s got nerve: roles of octopamine in insect female reproduction

White, Melissa; Chen, Dawn S; Wolfner, Mariana F.

doi:10.1080/01677063.2020.1868457

Cited by 31 publications

(36 citation statements)

References 245 publications

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“…Another humoral factor is the insect neurotransmitter octopamine (OA), an analog of mammalian noradrenaline ( Roeder, 2004 ; White et al, 2021b ). There are a number of octopaminergic neurons in the brain of D. melanogaster , a particular subset of neurons ( dsx + Tdc2 neurons) that project directly from the abdominal ganglion to the ovary.…”

Section: Humoral Factors That Transmit Mating Stimuli To Female Germline Stem Cellsmentioning

confidence: 99%

“…There are a number of octopaminergic neurons in the brain of D. melanogaster , a particular subset of neurons ( dsx + Tdc2 neurons) that project directly from the abdominal ganglion to the ovary. In addition, dsx + Tdc2 neurons are responsible for the regulation of egg-laying behavior ( Monastirioti, 2003 ; Rezával et al, 2014 ; Deady and Sun, 2015 ; White et al, 2021b ). Forced activation of these neurons results in an increase in the number of GSCs even in the virgin state ( Yoshinari et al, 2020 ).…”

Section: Humoral Factors That Transmit Mating Stimuli To Female Germline Stem Cellsmentioning

confidence: 99%

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Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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In many insect species, mating stimuli can lead to changes in various behavioral and physiological responses, including feeding, mating refusal, egg-laying behavior, energy demand, and organ remodeling, which are collectively known as the post-mating response. Recently, an increase in germline stem cells (GSCs) has been identified as a new post-mating response in both males and females of the fruit fly, Drosophila melanogaster. We have extensively studied mating-induced increase in female GSCs of D. melanogaster at the molecular, cellular, and systemic levels. After mating, the male seminal fluid peptide [e.g. sex peptide (SP)] is transferred to the female uterus. This is followed by binding to the sex peptide receptor (SPR), which evokes post-mating responses, including increase in number of female GSCs. Downstream of SP-SPR signaling, the following three hormones and neurotransmitters have been found to act on female GSC niche cells to regulate mating-induced increase in female GSCs: (1) neuropeptide F, a peptide hormone produced in enteroendocrine cells; (2) octopamine, a monoaminergic neurotransmitter synthesized in ovary-projecting neurons; and (3) ecdysone, a steroid hormone produced in ovarian follicular cells. These humoral factors are secreted from each organ and are received by ovarian somatic cells and regulate the strength of niche signaling in female GSCs. This review provides an overview of the latest findings on the inter-organ relationship to regulate mating-induced female GSC increase in D. melanogaster as a model. We also discuss the remaining issues that should be addressed in the future.

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Section: Humoral Factors That Transmit Mating Stimuli To Female Germline Stem Cellsmentioning

confidence: 99%

Section: Humoral Factors That Transmit Mating Stimuli To Female Germline Stem Cellsmentioning

confidence: 99%

Regulation of Mating-Induced Increase in Female Germline Stem Cells in the Fruit Fly Drosophila melanogaster

Hoshino

Niwa

2021

Front. Physiol.

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“…Even though we found that Methoprene treatment restores oogenesis in isolated females, it did not restore ovulation and egg-laying in these females, showing that in addition of JH pathway, other neuronal and/or hormonal pathways are involved in social modulation of Drosophila female reproduction. For instance, another pathway might be involved at the ovulation level such as octopaminergic (OA) neurons since these neurons innervate insects' ovary and oviducts allowing contraction of oviducts and the release of mature oocytes (Bloch Qazi et al, 2003;Li et al, 2015;Rodríguez-Valentín et al, 2006;White et al, 2021). It could explain the accumulation of mature stage 14 oocytes in ovaries of isolated females when presence of light.…”

Section: Interaction Between Light and Social Contextmentioning

confidence: 99%

Social modulation of oogenesis and egg-laying inDrosophila melanogaster

Tiphaine

Kohlmeier

Etienne

et al. 2021

Preprint

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Being part of a group facilitates cooperation between group members, but also creates competition for limited resources. This conundrum is problematic for gravid females who benefit from being in a group, but whose future offspring may struggle for access to nutrition in larger groups. Females should thus modulate their reproductive output depending on their social context. Although social-context dependent modulation of reproduction is documented in a broad range of species, its underlying mechanisms and functions are poorly understood. In the fruit fly Drosophila melanogaster, females actively attract conspecifics to lay eggs on the same resources, generating groups in which individuals may cooperate or compete. The tractability of the genetics of this species allows dissecting the mechanisms underlying physiological adaptation to their social context. Here, we show that females produce eggs increasingly faster as group size increases. By laying eggs faster in group than alone, females appear to reduce competition between offspring and increase their likelihood of survival. In addition, females in a group lay their eggs during the light phase of the day, while isolated females lay them during the night. We show that responses to the presence of others are determined by vision through the motion detection pathway and that flies from any sex, mating status or species can trigger these responses. The mechanisms of this modulation of egg-laying by group is connected to a lifting of the inhibition of light on oogenesis and egg-laying by stimulating hormonal pathways involving juvenile hormone. Because modulation of reproduction by social context is a hallmark of animals with higher levels of sociality, our findings represent a protosocial mechanism in a species considered solitary that may have been the target of selection for the evolution of more complex social systems.

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“…Aaron Reiss and Catherine Rankin provide a review of Marla's contributions to the field of behavioural genetics (Reiss & Rankin, 2021). Mariana Wolfner and colleagues provide a review on the role of octopamine in insect reproductive physiology and mating behavior (White, Chen, & Wolfner, 2021). Jamie Kramer and colleagues review courtship conditioning in Drosophila (Raun, Jones, & Kramer, 2021) and lastly, Christophe Lucas & Yehuda Ben-Shahar review the role of the foraging gene as a modulator of division of labour in social insects (Lucas & Ben-Shahar, 2021).…”

Section: Editorialmentioning

confidence: 99%