SHBG-Serumspiegel bei Frauen mit Endometriose vor, während und nach Danazol-Langzeittherapie

Abstract

Ten patients with endometriosis, aged from 21 to 37 years, were treated with danazol at a dosage level of 200 mg three times daily for 6 months. Three blood samples were drawn 60 min apart for evaluation of the sex hormone binding globulin (SHBG), before danazol administration (4th day of the cycle), during the last two weeks of the six-month therapy and three months after the cessation of treatment (4th day of the cycle). In contrast to that, SHBG levels were also evaluated in ten normal women, aged 21-37 years (4th day of the cycle). It was found that: a) SHGB values were significantly higher in patients with endometriosis than in the control group (p < 0.01), b) danazol resulted in significant decrease of SHBG levels (p < 0.001), c) there was no correlation between SHBG levels before and during danazol administration, and d) SHBG levels were significantly lower three months after the cessation of danazol than before the administration of the medication (p < 0.05), while these levels were not significantly different, compared with those of normal women. Our results support the view, that SHBG production disturbances might interfere with the possible pathogenetic mechanisms of infertility observed in endometriosis.

Endometriosis and polycystic ovary syndrome are diametric disorders

“…In contrast to PCOS, endometriosis is associated with increased SHBG and reduced serum and follicular testosterone (Frankfurter et al, 1997; Misao et al, 1995; Ono et al, 2014; Panidis et al, 1993). One study found that women with endometriosis had higher serum testosterone than unaffected controls, but this difference was not statistically significant (Evsen et al, 2014).…”

“…In contrast to PCOS, endometriosis is associated with increased SHBG and reduced serum and follicular testosterone (Frankfurter et al, 1997;Misao et al, 1995;Ono et al, 2014;Panidis et al, 1993).…”

The sexual selection of endometriosis.

“…Levels of serum SHBG are about twice as high in women than in men (Hammond, 2017), and SHBG levels in women show an inverse association with levels of testosterone (Hammond, 2017). Women with endometriosis show elevated levels of SHBG, in endometrium and serum, compared with controls (Misao et al, 1995; Panidis et al, 1993), and treatment of endometriosis with danazol leads to reduced SHBG levels (Panidis et al, 1993). The overexpression of SHBG in ectopic endometrium may also contribute to the high local estradiol levels found in this tissue in women with endometriosis (Misao et al, 1995).…”

Διερευνηση Του Ρολου Της Ινσουλινης Στη Δραστικοτητα Της Αρωματασης Ιν Vivo

“…Όσον αφορά το δεύτερο έμμεσο ενδεχόμενο μηχανισμό με τον οποίο η υπερινσουλιναιμία θα μπορούσε να προκαλέσει όχι υπερπαραγωγή ανδρογόνων αλλά αύξηση έκφρασης των ανδρογόνων, αύξηση δηλαδή της ιστικής διαθεσιμότητας των ανδρογόνων λόγω ελάττωσης των τιμών της σφαιρίνης που συνδέει τις ορμόνες του φύλου (SHBG), πρέπει να αναφερθούν τα εξής: είναι γνωστό από παλιά ότι τα επίπεδα της SHBG είναι χαμηλότερα στις ασθενείς με PCOS από ό,τι στις γυναίκες χωρίς το σύνδρομο, εύρημα που αποδόθηκε στην υπερανδρογοναιμία (193,194,195). Οι άντρες έχουν χαμηλότερα επίπεδα SHBG από ό,τι οι γυναίκες και η χορήγηση ανδρογόνων ή παράγωγων τους σε γυναίκες ελαττώνει τα επίπεδα της SHBG (196,197). In vitro μελέτες εντούτοις έδειξαν ότι τα ανδρογόνα αυξάνουν την παραγωγή της SHBG σε καλλιέργειες κυττάρων ηπατώματος (198).…”