Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Judák, Linda; Chiovini, Balázs; Juhász, Gábor; Pálfi, Dénes; Mezriczky, Zsolt; Szadai, Zoltán; Katona, Gergely; Szmola, Benedek; Ócsai, Katalin; Martinecz, Bernadett; Mihály, Anna; Kerekes, Bálint Péter; Szepesi, Aron; Szalay, Gergely; Ulbert, István; Mucsi, Zoltán; Roska, Botond; Rózsa, Balázs

doi:10.1038/s41467-022-34520-1

Cited by 11 publications

(7 citation statements)

References 81 publications

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“…In our recordings we observed a decrease in the percent of SWR events compared to SW events given that some SW did not exhibit a ripple event (Figure 1G – left panel). Additionally, some SW events had an embedded doublet ripple (Figure 1G – right panel), previously shown to be associated with dendritic summation in rodents (Judák et al, 2022). As a result, we based further analysis on our quantitatively and qualitatively analysis on SW events alone.…”

Section: Resultsmentioning

confidence: 54%

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Sharp wave ripple coupling in zebrafish hippocampus and basolateral amygdala

Blanco¹,

Caccavano²,

Wu³

et al. 2023

Preprint

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The mammalian hippocampus exhibits sharp wave events (1-30 Hz) with an often-present superimposed fast ripple oscillation (120-200 Hz) forming a sharp wave ripple (SWR) complex. During slow wave sleep or consummatory behaviors, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during imagined or learned experiences. SWRs occur in tandem with cortical/subcortical assemblies critical to the long-term storage of specific memory types. Leveraging juvenile zebrafish, we show that SWR events in their hippocampal homologue, the anterodorsolateral lobe (ADL), in ex vivo whole-brains are locally generated and maintained. SWR events were also recorded in the basolateral amygdala (BLA). Concomitant single cell calcium imaging and local field potential (LFP) recordings showed that BLA SWs couple to ADL SWs. Calcium imaging recordings of whole-brains demonstrated that ADL and BLA SWRs are endogenously and spontaneously silenced by the activation of a more caudal population of putative cholinergic cells. Electrical stimulation of this caudal region silenced ADL SWs. Our results suggest that the SWR-generating circuit is evolutionarily conserved through shared acetylcholine modulating mechanisms. These findings further our understanding of neuronal population dynamics in the zebrafish brain and highlights their advantage for simultaneously recording SW/SWRs and single cell activity in diverse brain regions.

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Section: Resultsmentioning

confidence: 54%

“…Additionally, some SW events had an embedded doublet ripple (Figure 1G right panel), previously shown to be associated with dendritic summation in rodents (Judák et al, 2022). As a result, we based further analysis on our quantitatively and qualitatively analysis on SW events alone.…”

Section: Swr Events In Juvenile Zebrafish Are Locally Generated and M...mentioning

confidence: 77%

Sharp wave ripple coupling in zebrafish hippocampus and basolateral amygdala

Blanco¹,

Caccavano²,

Wu³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In fast-spiking interneurons, AP back-propagation to dendrites is weaker than that in many other neuron types (Hu and Vervaeke, 2018). However, it is capable of activating voltage-sensitive L-type calcium channels and facilitating the activation of glutamate N-methyl-D-aspartate -receptor (NMDAR) channels in the dendrites, improving signal propagation for incoming synaptic inputs (Chiovini et al, 2014; Hu and Vervaeke, 2018; Judak et al, 2022). Weakening of the somatic sodium channel-mediated AP component in the fast-spiking interneuron soma suggests the attenuation of the AP’s back-propagation to the dendrites and reduced L-type calcium channel and glutamate NMDAR activation in dendritic branches.…”

Section: Discussionmentioning

confidence: 99%

Aging-associated weakening of the action potential in fast-spiking interneurons in the human neocortex

Szegedi,

Tiszlavicz,

Furdan

et al. 2024

Preprint

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Aging is associated with the slowdown of neuronal processing and cognitive performance in the brain; however, the exact cellular mechanisms behind this deterioration in humans are poorly elucidated. Recordings in human acute brain slices prepared from tissue resected during brain surgery enable the investigation of neuronal changes with age. Although neocortical fast-spiking cells are widely implicated in neuronal network activities underlying cognitive processes, they are vulnerable to neurodegeneration. Herein, we analyzed the electrical properties of 147 fast-spiking interneurons in neocortex samples resected in brain surgery from 106 patients aged 11–84 years. By studying the electrophysiological features of action potentials and passive membrane properties, we report that action potential overshoot significantly decreases and spike half-width increases with age. Moreover, the action potential maximum-rise speed (but not the repolarization speed or the afterhyperpolarization amplitude) significantly changed with age, suggesting a particular weakening of the sodium channel current generated in the soma. Cell passive membrane properties measured as the input resistance, membrane time constant, and cell capacitance remained unaffected by senescence. Thus, we conclude that the action potential in fast-spiking interneurons shows a significant weakening in the human neocortex with age. This may contribute to the deterioration of cortical functions by aging.

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“…Specific instructions telling subjects what to look for, or what to attend to, in a visual scene may generate top-down expectation signals strong enough to inhibit matching of other relevant signals at the same moment in time [31]. Top-down matching generates neural computations of event coincidence [63]. Results from certain observations in motor behavior without awareness [64] highlight potential implications of negative top-down matching for conscious control in learning.…”

Section: Temporary Representation For Selection and Controlmentioning

confidence: 99%

The Grossberg Code: Universal Neural Network Signatures of Perceptual Experience

Dresp-Langley

2023

Information

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Two universal functional principles of Grossberg’s Adaptive Resonance Theory decipher the brain code of all biological learning and adaptive intelligence. Low-level representations of multisensory stimuli in their immediate environmental context are formed on the basis of bottom-up activation and under the control of top-down matching rules that integrate high-level, long-term traces of contextual configuration. These universal coding principles lead to the establishment of lasting brain signatures of perceptual experience in all living species, from aplysiae to primates. They are re-visited in this concept paper on the basis of examples drawn from the original code and from some of the most recent related empirical findings on contextual modulation in the brain, highlighting the potential of Grossberg’s pioneering insights and groundbreaking theoretical work for intelligent solutions in the domain of developmental and cognitive robotics.

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Sharp-wave ripple doublets induce complex dendritic spikes in parvalbumin interneurons in vivo

Cited by 11 publications

References 81 publications

Sharp wave ripple coupling in zebrafish hippocampus and basolateral amygdala

Sharp wave ripple coupling in zebrafish hippocampus and basolateral amygdala

Aging-associated weakening of the action potential in fast-spiking interneurons in the human neocortex

The Grossberg Code: Universal Neural Network Signatures of Perceptual Experience

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