Shared Mutations in Emerging SARS-CoV-2 Circulating Variants May Lead to Reverse Transcription-PCR (RT-PCR)-Based Misidentification of B.1.351 and P.1 Variants of Concern

Losada, Carmen; Rico-Luna, Carla; Otero-Sobrino, Álvaro; Molero-Salinas, Andrea; Buenestado‐Serrano, Sergio; Candela, Ana; Pérez‐Lago, Laura; Muñóz, Patricia; Catalán, Pilar; Viedma, Darı́o Garcı́a de

doi:10.1128/spectrum.00816-21

Cited by 1 publication

(1 citation statement)

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“…Phylodynamic reconstruction indicated a high level of variability with an exponential growth of lineages until May-June 2021 [8,9]. Subsequent Variants of Concern (VOCs), such as B.1.351 (β) and P.1 (γ), first identified in South Africa and Brazil, respectively [10], were primarily characterized by mutations E484K and N501Y [11]. They exhibited heightened contagion and resistance to neutralization by antibodies from convalescent and vaccine-recipient individuals, raising concerns, including issues related to misidentification due to shared mutations [12].…”

Section: First Lineages and First Variantsmentioning

confidence: 99%

On the SARS-CoV-2 Variants

Scarpa,

Branda,

Petrosillo

et al. 2024

Infectious Disease Reports

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The evolutionary dynamics of viruses, particularly exemplified by SARS-CoV-2 during the ongoing COVID-19 pandemic, underscore the intricate interplay between genetics, host adaptation, and viral spread. This paper delves into the genetic evolution of SARS-CoV-2, emphasizing the implications of viral variants on global health. Initially emerging from the Wuhan-Hu-1 lineage, SARS-CoV-2 rapidly diversified into numerous variants, each characterized by distinct mutations in the spike protein and other genomic regions. Notable variants such as B.1.1.7 (α), B.1.351 (β), P.1 (γ), B.1.617.2 (δ), and the Omicron variant have garnered significant attention due to their heightened transmissibility and immune evasion capabilities. In particular, the Omicron variant has presented a myriad of subvariants, raising concerns about its potential impact on public health. Despite the emergence of numerous variants, the vast majority have exhibited limited expansion capabilities and have not posed significant threats akin to early pandemic strains. Continued genomic surveillance is imperative to identify emerging variants of concern promptly. While genetic adaptation is intrinsic to viral evolution, effective public health responses must be grounded in empirical evidence to navigate the evolving landscape of the pandemic with resilience and precision.

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Section: First Lineages and First Variantsmentioning

confidence: 99%