Shared microbiome in gums and the lung in an outpatient population

Schmidlin, Patrick R.; Fachinger, Patrick; Tini, Gabrielo M.; Graber, Sereina M; Seifert, Burkhardt; Dombrowa, Sylke; Irani, Sarosh

doi:10.1016/j.jinf.2014.10.005

Cited by 11 publications

(13 citation statements)

References 31 publications

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“…We thus provided basic agreement indices, but wider use of this score would require an in-depth reliability assessment and validation. If we turn back to biological processes, earlier primary studies ignored microbiomes, while some novel studies are suggesting that lungs are not sterile 78 79 and that respiratory tract microbiomes could have strong modifying effect on health and disease mechanisms. Despite all these limitations, we attempted to provide a field synopsis, supplemented by a generalized framework that could be useful not only for respiratory infectious disease genetics, but can be extended to all infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

Patarčić

Gelemanović

Kirin

et al. 2015

Sci Rep

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Host genetic factors have frequently been implicated in respiratory infectious diseases, often with inconsistent results in replication studies. We identified 386 studies from the total of 24,823 studies identified in a systematic search of four bibliographic databases. We performed meta-analyses of studies on tuberculosis, influenza, respiratory syncytial virus, SARS-Coronavirus and pneumonia. One single-nucleotide polymorphism from IL4 gene was significant for pooled respiratory infections (rs2070874; 1.66 [1.29–2.14]). We also detected an association of TLR2 gene with tuberculosis (rs5743708; 3.19 [2.03–5.02]). Subset analyses identified CCL2 as an additional risk factor for tuberculosis (rs1024611; OR = 0.79 [0.72–0.88]). The IL4-TLR2-CCL2 axis could be a highly interesting target for translation towards clinical use. However, this conclusion is based on low credibility of evidence - almost 95% of all identified studies had strong risk of bias or confounding. Future studies must build upon larger-scale collaborations, but also strictly adhere to the highest evidence-based principles in study design, in order to reduce research waste and provide clinically translatable evidence.

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Section: Discussionmentioning

confidence: 99%

The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

Patarčić

Gelemanović

Kirin

et al. 2015

Sci Rep

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“…The community composition of bronchial tree is reported to be similar with the upper airways, but the biomass is less, indicating that aspiration from the upper airways may be the source of lung microbiome. [ 25 26 27 ] Charlson et al . [ 25 ] showed that there were similarities in the microbiologic pattern in the oropharynx and bronchial tree, indicating that there is no unique lung microbiome.…”

Section: Ung M Icrobiomementioning

confidence: 99%

Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Wang

Hao

Yang

et al. 2017

Chinese Medical Journal

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Objective:The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease (COPD) individuals. With the advance of sequencing technologies, lung microbiome has become a new frontier for pulmonary disease research, and such advance has led to better understanding of the lung microbiome in COPD. This review aimed to summarize the recent advances in lung microbiome, its relationships with COPD, and the possible mechanisms that microbiome contributed to COPD pathogenesis.Data Sources:Literature search was conducted using PubMed to collect all available studies concerning lung microbiome in COPD. The search terms were “microbiome” and “chronic obstructive pulmonary disease”, or “microbiome” and “lung/pulmonary”.Study Selection:The papers in English about lung microbiome or lung microbiome in COPD were selected, and the type of articles was not limited.Results:The lung is a complex microbial ecosystem; the microbiome in lung is a collection of viable and nonviable microbiota (bacteria, viruses, and fungi) residing in the bronchial tree and parenchymal tissues, which is important for health. The following types of respiratory samples are often used to detect the lung microbiome: sputum, bronchial aspirate, bronchoalveolar lavage, and bronchial mucosa. Disordered bacterial microbiome is participated in pathogenesis of COPD; there are also dynamic changes in microbiota during COPD exacerbations. Lung microbiome may contribute to the pathogenesis of COPD by manipulating inflammatory and/or immune process.Conclusions:Normal lung microbiome could be useful for prophylactic or therapeutic management in COPD, and the changes of lung microbiome could also serve as biomarkers for the evaluation of COPD.

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“…Among these chronic diseases newly discovered connections with the oral microbiome and/or its specific constituent species have been found with lung inflammatory diseases [68], non-alcoholic fatty liver disease [69], and chronic kidney disease [70]. …”

Section: Other Chronic Diseases and Oral Microbesmentioning

confidence: 99%

Section: Other Chronic Diseases and Oral Microbesmentioning

confidence: 99%

“…A 2014 prospective outpatient study examining a total of 94 bronchoscopy patients showed a statistically significant correlation between the presences of P. gingivalis , A. actinomycetemcomitans , T. forsythia, and T. denticola in bronchial samples and in saliva samples [68]. The same study also showed increased concentration of MMP8 in the bronchial fluid of patients with periodontal pathogens detectable in the lung compared to patients who didn’t harbor periodontal pathogens (p = 0.09) [68]. Similar association was observed between P. gingivalis prevalence in oral swabs and non-alcoholic fatty liver disease (NAFLD) in a 2012 cohort study involving 102 patients with non-alcoholic steatohepatitis, 48 with non-alcoholic fatty liver and 60 non-NAFLD control subjects [69].…”

Section: Other Chronic Diseases and Oral Microbesmentioning

confidence: 99%

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Prelude to oral microbes and chronic diseases: past, present and future

Atanasova

Yılmaz

2015

Microbes and Infection

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Associations between oral and systemic health are ancient. Oral opportunistic bacteria, particularly, Porphyromonas gingivalis and Fusobacterium nucleatum, have recently been deviated from their traditional roles and arguably ascended to central players based on their participations in complex co-dependent mechanisms of diverse systemic chronic diseases risk and pathogenesis, including cancers, rheumatoid-arthritis, and diabetes.

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Shared microbiome in gums and the lung in an outpatient population

Cited by 11 publications

References 31 publications

The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis

Role of the Lung Microbiome in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Prelude to oral microbes and chronic diseases: past, present and future

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