Shared Genetic Vulnerability for Disordered Gambling and Alcohol Use Disorder in Men and Women: Evidence from a National Community-Based Australian Twin Study

Slutske, Wendy S.; Ellingson, Jarrod M.; Richmond‐Rakerd, Leah S.; Zhu, Gu; Martin, Nicholas G.

doi:10.1017/thg.2013.11

Cited by 116 publications

(54 citation statements)

References 47 publications

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“…Corroborating prior research, we found significant genetic and non-shared environmental effects on AUD (Dick et al, 2009; Edwards et al, 2013; Grant et al, 2009; Slutske et al, 2013; Trace et al, 2013b) and bulimic behaviors (Baker et al, 2010; Klump et al, 2000; Munn-Chernoff et al, 2013, 2015; Slane et al, 2012; Sullivan et al, 1998; Trace et al, 2013a, 2013b). Although the heritability estimates for AUD were numerically higher and for bulimic behaviors were numerically lower in AA than in EA women, these differences were not statistically significant.…”

Section: Discussionsupporting

confidence: 81%

“…In European ancestry samples, heritability estimates for AUD range from 50% to 64% (Baker et al, 2010; Dick et al, 2009; Edwards et al, 2013; Grant et al, 2009; Slutske et al, 2013; Trace et al, 2013b), 28% to 83% for bulimia nervosa (Trace et al, 2013a), and 8% to 72% for bulimic behaviors (Baker et al, 2010; Klump et al, 2000; Munn-Chernoff et al, 2013, 2015; Slane et al, 2012; Sullivan et al, 1998; Wade et al, 2008), with generally little evidence for environmental effects shared among family members. Studies including non-European ancestry twins reported possible distinctions in magnitudes of genetic and environmental effects on problem alcohol use (Sartor et al, 2013) but similar heritability estimates for binge eating (Munn-Chernoff et al, 2015) in EA versus AA women.…”

Section: Introductionmentioning

confidence: 99%

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Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women

Munn‐Chernoff

Grant

Agrawal

et al. 2015

Drug and Alcohol Dependence

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Background Despite substantial evidence that alcohol use disorder (AUD) and bulimic behaviors (i.e., binge eating and compensatory behaviors) co-occur, insufficient information exists regarding a possible shared etiology. Moreover, although numerous twin studies of European ancestry individuals have reported moderate heritability estimates for AUD and bulimic behaviors, with little evidence for shared environmental factors, research on genetic and environmental risk in African American (AA) individuals is lacking. Methods We investigated specific and overlapping genetic and environmental influences on AUD and bulimic behaviors in 3,232 European American (EA; 55.38% monozygotic) and 549 AA (42.81% monozygotic) young adult female twins from the Missouri Adolescent Female Twin Study (age range=18–29 years). A structured clinical interview assessed lifetime DSM-5 AUD (minus craving) and bulimic behaviors. Biometrical twin modeling was conducted to generate age-adjusted estimates of genetic and environmental influences on AUD, bulimic behaviors, and their comorbidity. Results Estimates of genetic and environmental contributions on AUD and bulimic behaviors could be equated across EA and AA women. Additive genetic effects accounted for 59% (95% CI: 50%, 66%) and 43% (33%, 52%) of the variance in AUD and bulimic behaviors, respectively, with the remainder due to non-shared environmental effects. Shared genetic factors (rg=.33 (.18, .49)) were solely responsible for the correlation between phenotypes; the non-shared environmental correlation was not significant (re=.10 (− .05, .25)). Conclusions Findings indicate similar magnitudes of genetic and environmental effects on AUD and bulimic behaviors for EA and AA women and implicate common genetic mechanisms underlying liability to these problem behaviors.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women

Munn‐Chernoff

Grant

Agrawal

et al. 2015

Drug and Alcohol Dependence

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“…Examples of shared risk factors for both gambling and substance use include family history, mental health problems, and gender (Barnes et al, 1999; Cook et al, 2015; Mezzich et al, 2001; Vitaro et al, 2014). A recent study utilizing adolescent twin pairs found a significant genetic influence on both gambling and substance use (Vitaro et al, 2014), which is consistent with other research among adults (Slutske et al, 2000; Slutske et al, 2013). Longitudinal data examining gender as a risk factor show an association between gambling problems and incident alcohol dependence among men (Pilver et al, 2013).…”

Section: Introductionsupporting

confidence: 87%

Risk factors for gambling and substance use among recent college students

Caldeira

Arria

O’Grady

et al. 2017

Drug and Alcohol Dependence

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Background While it is well known that substance use and gambling overlap, the degree to which this overlap can be explained by shared risk factors has not been fully explored. This study aimed to identify common and unique risk factors for gambling and substance use among young adults. Methods Young adults (n=1,019) in a longitudinal study since college entry were interviewed annually. Past-year frequency of seven gambling activities was assessed once (Year 5). Structural equation models evaluated suspected risk factors in two models, one for gambling with substance use as an intermediary variable, and one for substance use with gambling as the intermediary variable. Results Sixty percent gambled; 6% gambled weekly or more. Examination of the two structural models supported the existence of significant paths (a) from two of the five substance use variables (alcohol, drugs) to gambling frequency, and (b) from gambling frequency to all five substance use variables. Every risk factor associated with gambling was also associated with one or more substance use variables. Risk factors common to gambling and substance use were sex, race/ethnicity, extracurricular involvement (fraternity/sorority, athletics), impulsive sensation-seeking, and behavioral dysregulation. Risk factors unique to substance use were conduct problems, anxiety, and parent’s history of alcohol and mental health problems. Conclusions Gambling and substance use are interrelated, but with incomplete overlap in their respective risk factors. Results underscore the need for longitudinal research to elucidate their distinct etiologies.

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“…Mplus is especially well-suited for this purpose because it allows for the proper factor analysis of dichotomous data (by using tetrachoric and biserial correlations). A similar approach has previously been used to create a lifetime disordered gambling factor (Lind et al, 2013; Slutske et al, 2013b). …”

Section: Methodsmentioning

confidence: 99%

Local area disadvantage and gambling involvement and disorder: Evidence for gene-environment correlation and interaction.

Slutske¹,

Deutsch²,

Statham³

et al. 2015

Journal of Abnormal Psychology

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Previous research has demonstrated that local area characteristics (such as disadvantage and gambling outlet density) and genetic risk factors are associated with gambling involvement and disordered gambling. These two lines of research were brought together in the present study by examining the extent to which genetic contributions to individual differences in gambling involvement and disorder contributed to being exposed to, and were also accentuated by, local area disadvantage. Participants were members of the national community-based Australian Twin Registry who completed a telephone interview in which the past-year frequency of gambling and symptoms of disordered gambling were assessed. Indicators of local area disadvantage were based on census data matched to the participants' postal codes. Univariate biometric model-fitting revealed that exposure to area disadvantage was partially explained by genetic factors. Bivariate biometric model-fitting was conducted to examine the evidence for gene-environment interaction while accounting for gene-environment correlation. These analyses demonstrated that: (a) a small portion of the genetic propensity to gamble was explained by moving to or remaining in a disadvantaged area, and (b) the remaining genetic and unique environmental variation in the frequency of participating in electronic machine gambling (among men and women) and symptoms of disordered gambling (among women) was greater in more disadvantaged localities. As the gambling industry continues to grow, it will be important to take into account the multiple contexts in which problematic gambling behavior can emerge -- from genes to geography -- as well as the ways in which such contexts may interact with each other.

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Shared Genetic Vulnerability for Disordered Gambling and Alcohol Use Disorder in Men and Women: Evidence from a National Community-Based Australian Twin Study

Cited by 116 publications

References 47 publications

Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women

Genetic overlap between alcohol use disorder and bulimic behaviors in European American and African American women

Risk factors for gambling and substance use among recent college students

Local area disadvantage and gambling involvement and disorder: Evidence for gene-environment correlation and interaction.

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