Shared genetic influences between depression and conduct disorder in children and adolescents: A systematic review

Reconsidering the failure model: Using a genetically controlled design to assess the spread of problems from reactive aggression to internalizing symptoms through peer rejection across the primary school years

“…Similar findings have emerged in research including both twin‐based biometric modeling and genome‐wide polygenic risk score analyses; shared genetic influences largely contributed to the co‐occurrence and co‐development of symptom trajectories for internalizing and externalizing problems throughout childhood and adolescence (Hannigan et al, 2018). Taken together, these findings suggest that there is a substantial degree of genetic influence that overlaps between internalizing and externalizing symptoms (see Caserini et al, 2023). These findings align with the proposal of a general psychopathology factor (i.e., p; Caspi et al, 2014) that represents an underlying liability for developing multiple forms of psychopathology and assumes that different forms of psychopathology are influenced by a general genetic factor (Caspi & Moffitt, 2018).…”

Conduct Disorder: An Update

“…Clinical studies have shown that approximately 50% of children and adolescents diagnosed with conduct disorders meet the diagnostic criteria for major depressive disorders or dysthymia. Moreover, these two disorders are reported to increase the likelihood of substance use problems and suicide in adolescence (Caserini et al 2023). Although children who are not diagnosed with conduct disorder but have anxiety disorder are also at risk of developing conduct disorder in adolescence, which is a later period of their lives, children and adolescents diagnosed with conduct disorder are more likely to develop anxiety disorder (Ateş 2014(Ateş , Çıkılı 2015.…”