Shared demographics and comorbidities in different functional motor disorders

Gelauff, Jeannette M.; Rosmalen, Judith; Gardien, J.; Stone, Jon; Tijssen, Marina A. J.

doi:10.1016/j.parkreldis.2019.11.018

Cited by 28 publications

(42 citation statements)

References 36 publications

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“…The majority of patients were women with a median age at the symptoms onset of 35 years old, with a wide age range. These demographic characteristics are similar to those of previous smaller cohorts of adults suffering from FMDs, which reported a proportion of women between 48 and 84% and a mean age at onset between 29.7 and 46.9 years old (Factor, Podskalny, et Molho 1995; Binzer, Andersen, et Kullgren 1997; Schrag et al 2004; Jon Stone, Warlow, et Sharpe 2010; Pandey et Koul 2017; Baizabal-Carvallo et Jankovic 2020; Tinazzi et al 2020; Anderson et al 2007; Gelauff et al 2020)(see table 4). It should be noted that extreme ages were under-represented, since wee did not include children, and older patients may be under diagnosed.…”

Section: Discussionsupporting

confidence: 86%

Demographic and clinical characteristics of patients with functional motor disorders: the prospective Salpêtrière cohort

Garcin

Villain

Mesrati

et al. 2021

Preprint

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Functional motor disorders (FMD) are common and disabling. They are known to affect predominantly women and to start at young or middle age but to date, large case series are lacking, and demographic and clinical characteristics of patients with FMD rely on data from small cohorts. The aim of the current study was to describe demographic and clinical characteristics of these patients. Methods: We prospectively collected data from FMD patients who were referred to the Neurophysiology Department of the Pitie-Salpetriere University Hospital between 2008 and 2016 for treatment with repeated transcranial magnetic stimulation. Results: 482 patients were included. There was a majority of women (73.7%) with a median age of 40 years old at TMS treatment. Median age at the onset of the symptoms was 35.5 years old and symptoms were mostly characterized by an acute (47.3%) or subacute (46%) onset. Only 23% of patients were active workers while 58.3% were unemployed for medical reasons. Half of the patients referred for TMS treatment suffered from functional motor weakness (n= 241) and the other half suffered from movement disorders (n=241), mainly represented by tremor (21.15%) and dystonia (20.5%). Regarding psychiatric comorbidities, 33.6% had no psychiatric comorbidity and 17.4% reported no history of trauma. No significant differences were found according to clinical phenotypes. Conclusion: We present the largest cohort of patients with FMD published to date. This cohort will contribute to a better understanding of FMD risk factors.

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Section: Discussionsupporting

confidence: 86%

Demographic and clinical characteristics of patients with functional motor disorders: the prospective Salpêtrière cohort

Garcin

Villain

Mesrati

et al. 2021

Preprint

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“…In our sample, the clinical spectrum of FMDs was often enriched by a constellation of physical and psychiatric symptoms, such as anxiety, pain, and fatigue. Pain and fatigue are common symptoms in patients with FMDs and should be recognized when planning treatment strategies 13–15 . In addition, patients often had functional sensory symptoms (25.3%) and PNES (13.6%), which represent the most frequent FND manifestations in outpatient clinics 37 …”

Section: Discussionmentioning

confidence: 99%

“…Cross-cultural comparisons of educational level are needed. Phenomenological descriptions of FMDs have been extensively reported in the literature, 2,13,14,16,24,[31][32][33][34][35] but most of these studies have a retrospective design and/or were based on tertiary movement disorders referral centers or a specialistic FND clinic. Indeed, data on the prevalence of different phenotypes from large cohorts are missing.…”

Section: Demographic and Clinical Features Of Fmdsmentioning

confidence: 99%

“…Pain and fatigue are common symptoms in patients with FMDs and should be recognized when planning treatment strategies. [13][14][15] In addition, patients often had functional sensory symptoms (25.3%) and PNES (13.6%), which represent the most frequent FND manifestations in outpatient clinics. 37 A formal psychiatric diagnosis, more frequently anxiety and depression, was delivered in 40.2% of subjects, and only a minority of them reported childhood predisposing trauma.…”

Section: Demographic and Clinical Features Of Fmdsmentioning

confidence: 99%

“…9 A few studies have provided insights on the frequency of different FMD phenotypes and their association with nonmotor symptoms and other FNDs. [13][14][15][16] However, these reports had a retrospective design 14 or were based on reviews of clinical notes or email contact with the treating neurologists 13 or included cohorts followed up in tertiary referral centers 16 or FND specialist clinics. 14 Finally, it is unclear if people having single (isolated FMD) or multiple (combined FMDs) motor manifestations may differ for associated demographic and clinical variables.…”

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confidence: 99%

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Clinical Correlates of Functional Motor Disorders: An Italian Multicenter Study

Tinazzi

Morgante

Marcuzzo

et al. 2020

Movement Disord Clin Pract

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Background Background: Functional motor disorders (FMDs) are abnormal movements that are significantly altered by distractive maneuvers and are incongruent with movement disorders seen in typical neurological diseases. Objective Objective: The objectives of this article are to (1) describe the clinical manifestations of FMDs, including nonmotor symptoms and occurrence of other functional neurological disorders (FND); and (2) to report the frequency of isolated and combined FMDs and their relationship with demographic and clinical variables. Methods Methods: For this multicenter, observational study, we enrolled consecutive outpatients with a definite diagnosis of FMDs attending 25 tertiary movement disorders centers in Italy. Each patient underwent a detailed clinical evaluation with a definition of the phenotype and number of FMDs (isolated, combined) and an assessment of associated neurological and psychiatric symptoms. Results Results: Of 410 FMDs (71% females; mean age, 47 AE 16.1 years) the most common phenotypes were weakness and tremor. People with FMDs had higher educational levels than the general population and frequent nonmotor symptoms, especially anxiety, fatigue, and pain. Almost half of the patients with FMDs had other FNDs, such as sensory symptoms, nonepileptic seizures, and visual symptoms. Patients with combined FMDs showed a higher burden of nonmotor symptoms and more frequent FNDs. Multivariate regression analysis showed that a diagnosis of combined FMDs was more likely to be delivered by a movement disorders

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Functional Dystonia

Morgante

2022

Current Clinical Neurology

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Shared demographics and comorbidities in different functional motor disorders

Cited by 28 publications

References 36 publications

Demographic and clinical characteristics of patients with functional motor disorders: the prospective Salpêtrière cohort

Demographic and clinical characteristics of patients with functional motor disorders: the prospective Salpêtrière cohort

Clinical Correlates of Functional Motor Disorders: An Italian Multicenter Study

Functional Dystonia

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