Shared decision-making before prostate cancer screening decisions

Pekala, Kelly R.; Shill, Daniela K.; Austria, Mia; Langford, Aisha T.; Loeb, Stacy; Carlsson, Sigrid V.

doi:10.1038/s41585-023-00840-0

Nat Rev Urol

2024

DOI: 10.1038/s41585-023-00840-0

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Shared decision-making before prostate cancer screening decisions

Kelly R. Pekala,

Daniela K. Shill,

Mia Austria

et al.

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2024

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Cited by 3 publications

References 58 publications

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Prostate Cancer Early Detection in the European Union and UK

Leenen,

Venderbos,

Helleman

et al. 2024

European Urology

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Prostate Cancer Early Detection in the European Union and UK

Leenen,

Venderbos,

Helleman

et al. 2024

European Urology

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Folded flexure MOEMS for the detection of PSA and hepatitis DNA as biosensor for prostate cancer and viruses

Bahramian,

Gholinejad,

Yazdanpanah Goharrizi

2024

Sci Rep

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Micro-opto-electro-mechanical systems (MOEMS) biosensors are employed in various applications such as disease monitoring, drug investigation, detection of pollutants, and biological fluid studies. In this paper, a novel MOEMS biosensor based on a differential folded-flexure structure is introduced. The designed device is employed to detect prostate-specific antigen (PSA) protein and Hepatitis DNA. The target molecules cause a mechanical deflection in the folded-flexure; subsequently, the transmitted optical power across the finger, attached to the flexure, is modulated in proportion to the input concentration. Then, a photodiode power sensor measures the modulated optical power, where the output of the sensor is simply a current related to the target molecules’ concentrations. The employed readout circuit operates at a wavelength of λ = 1550 nm with a laser power of 1 µW. The dimensions of the proposed biosensor are considered to be 365 × 340 × 2 μm³, making this sensor small enough and suitable for integration. The designed biosensor provides notable features of mechanical deflection sensitivities of 0.2053 nm/(ng/ml) and 7.2486 nm/nM, optical transmittance sensitivities of 0.535504 × 10−3 1/(ng/ml) and 18.91 × 10−3 1/nM, total output sensitivities of 0.5398 (mA/W)/(ng/ml) and 19.059 (mA/W)/nM, and measurement ranges of 0-1000 ng/ml and 0-28.33 nM for PSA and Hepatitis DNA, respectively. The proposed system is a sensitive and powerful sensor that can play an important role in diagnosing many diseases.

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Prostate Cancer Foundation Screening Guidelines for Black Men in the United States

Garraway,

Carlsson,

Nyame

et al. 2024

NEJM Evidence

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Shared decision-making before prostate cancer screening decisions

Cited by 3 publications

References 58 publications

Prostate Cancer Early Detection in the European Union and UK

Prostate Cancer Early Detection in the European Union and UK

Folded flexure MOEMS for the detection of PSA and hepatitis DNA as biosensor for prostate cancer and viruses

Prostate Cancer Foundation Screening Guidelines for Black Men in the United States

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