Shared and specific functional connectivity alterations in unmedicated bipolar and major depressive disorders based on the triple-network model

Wang, Junjing; Wang, Ying; Wu, Xia; Huang, Huiyuan; Jia, Yanbin; Zhong, Shuming; Wu, Xiaoyan; Zhao, Lianping; He, Yuan; Huang, Li; Huang, Ruiwang

doi:10.1007/s11682-018-9978-x

Cited by 75 publications

(36 citation statements)

References 80 publications

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“…In contrast, Meda and colleagues (2014) used a para‐ICA approach targeting the DMN to report reduced global functional connectivity in regions of the DMN including the mPFC, PCC, and precuneus as consistent with the ROI‐based study findings, and further suggest selective nodes within the DMN that may be heritable through genetic associations. The reduced functional connectivity of the DMN at rest was also supported in studies (Öngür et al., 2010; Wang, Wang, et al, 2018).…”

Section: Resultssupporting

confidence: 64%

“…Brandt and colleagues (2014) performed a 36‐component principal component analysis (PCA) to demonstrate that ICs that make up the CEN and the dorsal attention network are significantly altered in individuals with bipolar disorder compared to the healthy control at task‐based situations, although the direction of this alteration was not specified. In addition, weaker functional connectivity among the anterior insula of the SAN, and the DLPFC of the CEN was also reported (Wang, Wang, et al, 2018). Findings also showed that weaker intranetwork functional connectivity was prevalent for all three of the triple network model (Wang et al, 2019a), where more time was spent in the phase where all 3 networks have sparse functional connections as compared to the healthy control group.…”

Section: Resultsmentioning

confidence: 91%

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Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Yoon

Kim²,

Kim

et al. 2020

Brain and Behavior

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Background Growing literature continues to identify brain regions that are functionally altered in bipolar disorder. However, precise functional network correlates of bipolar disorder have yet to be determined due to inconsistent results. The overview of neurological alterations from a large‐scale network perspective may provide more comprehensive results and elucidate the neuropathology of bipolar disorder. Here, we critically review recent neuroimaging research on bipolar disorder using a network‐based approach. Methods A systematic search was conducted on studies published from 2009 through 2019 in PubMed and Google Scholar. Articles that utilized functional magnetic resonance imaging technique to examine altered functional activity of major regions belonging to a large‐scale brain network in bipolar disorder were selected. Results A total of 49 studies were reviewed. Within‐network hypoconnectivity was reported in bipolar disorder at rest among the default mode, salience, and central executive networks. In contrast, when performing a cognitive task, hyperconnectivity among the central executive network was found. Internetwork functional connectivity in the brain of bipolar disorder was greater between the salience and default mode networks, while reduced between the salience and central executive networks at rest, compared to control. Conclusion This systematic review suggests disruption in the functional activity of large‐scale brain networks at rest as well as during a task stimuli in bipolar disorder. Disrupted intra‐ and internetwork functional connectivity that are also associated with clinical symptoms suggest altered functional connectivity of and between large‐scale networks plays an important role in the pathophysiology of bipolar disorder.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 91%

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Yoon

Kim²,

Kim

et al. 2020

Brain and Behavior

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“…Of note, this meta-analysis included eight ALFF studies and eight rCBF studies. More recently, several rs-fMRI studies found altered functional connectivity between the insula-centric salience network (SN) and the default mode network (DMN), and the central executive network (CEN) in MDD and BD 35 , 36 . The insula-mediated dynamic switching between the DMN and the CEN facilitates access to cognitive resources, such as attention and working memory, when a salient event is detected.…”

Section: Discussionmentioning

confidence: 99%

Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis

et al. 2020

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Identification of intrinsic brain activity differences and similarities between major depression (MDD) and bipolar disorder (BD) is necessary. However, results have not yet yielded consistent conclusions. A meta-analysis of whole-brain resting-state functional MRI (rs-fMRI) studies that explored differences in the amplitude of low-frequency fluctuation (ALFF) between patients (including MDD and BD) and healthy controls (HCs) was conducted using seed-based d mapping software. Systematic literature search identified 50 studies comparing 1399 MDD patients and 1332 HCs, and 15 studies comparing 494 BD patients and 593 HCs. MDD patients displayed increased ALFF in the right superior frontal gyrus (SFG) (including the medial orbitofrontal cortex, medial prefrontal cortex [mPFC], anterior cingulate cortex [ACC]), bilateral insula extending into the striatum and left supramarginal gyrus and decreased ALFF in the bilateral cerebellum, bilateral precuneus, and left occipital cortex compared with HCs. BD showed increased ALFF in the bilateral inferior frontal gyrus, bilateral insula extending into the striatum, right SFG, and right superior temporal gyrus (STG) and decreased ALFF in the bilateral precuneus, left cerebellum (extending to the occipital cortex), left ACC, and left STG. In addition, MDD displayed increased ALFF in the left lingual gyrus, left ACC, bilateral precuneus/posterior cingulate gyrus, and left STG and decreased ALFF in the right insula, right mPFC, right fusiform gyrus, and bilateral striatum relative to BD patients. Conjunction analysis showed increased ALFF in the bilateral insula, mPFC, and decreased ALFF in the left cerebellum in both disorders. Our comprehensive meta-analysis suggests that MDD and BD show a common pattern of aberrant regional intrinsic brain activity which predominantly includes the insula, mPFC, and cerebellum, while the limbic system and occipital cortex may be associated with spatially distinct patterns of brain function, which provide useful insights for understanding the underlying pathophysiology of brain dysfunction in affective disorders, and developing more targeted and efficacious treatment and intervention strategies.

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“…The three core networks include: the default mode network (DMN), which is involved in interoceptive and self-referential processing ( Sheline et al, 2009 ); the central executive network (CEN), which is involved in goal-directed behavior; and the salience network (SN), which is thought to control switching between the DMN and CEN. Several studies have now investigated these networks directly in individuals with MDD and revealed both within- and between-network alterations ( Manoliu et al, 2013 , Wang et al, 2020a , Wang et al, 2020b ). In addition, meta-analyses found that emotional processing in MDD largely involved the three core networks ( Hamilton et al, 2012 , Groenewold et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Multilayer MEG functional connectivity as a potential marker for suicidal thoughts in major depressive disorder

Nugent

Ballard

Gilbert

et al. 2020

NeuroImage: Clinical

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Highlights Generalized slowing of connectivity was seen in those with MDD vs healthy subjects. Slowing from alpha/beta-mediated to delta/theta-mediated connectivity was observed. Connectivity strength and suicidal thoughts were linked in MDD subjects. “Hub” regions in the brain potentially underlying suicidal thoughts were identified. Connectivity differed between those with high suicidal thought scores and controls.

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Shared and specific functional connectivity alterations in unmedicated bipolar and major depressive disorders based on the triple-network model

Cited by 75 publications

References 80 publications

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Altered functional activity in bipolar disorder: A comprehensive review from a large‐scale network perspective

Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis

Multilayer MEG functional connectivity as a potential marker for suicidal thoughts in major depressive disorder

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