Shared abnormality of white matter integrity in schizophrenia and bipolar disorder: A comparative voxel-based meta-analysis

Dong, Debo; Wang, Yulin; Chang, Xuebin; Jiang, Yuchao; Klugah‐Brown, Benjamin; Chen, Luo; Yao, Dezhong

doi:10.1016/j.schres.2017.01.005

Cited by 69 publications

(55 citation statements)

References 85 publications

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“…The small cluster we identified, was not localized exclusively in one WM-region, but comprised right SLF and right cingulate gyrus (CG). The localization of the FAabnormalities is in line with previous studies identifying altered WMmicrostructure in UHR-individuals (Clemm Von Hohenberg et al, 2014;Krakauer et al, 2017) and patients with schizophrenia (Hatton et al, 2014) and affective disorders (Dong et al, 2017). Our ROIanalysis confirmed the finding of lower FA in SLF in UHR-individuals compared to HC.…”

Section: Discussionsupporting

confidence: 91%

Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra‐high risk for psychosis

Kristensen

Mandl

Raghava

et al. 2019

Human Brain Mapping

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In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra‐high risk for psychosis. One hundred and sixteen individuals at ultra‐high risk for psychosis and 49 matched healthy controls underwent 3 T magnetic resonance diffusion‐weighted imaging and cognitive assessments. Group differences on fractional anisotropy were tested using tract‐based spatial statistics. Group differences in cognitive functions, voxel‐wise as well as regional fractional anisotropy were tested using univariate general linear modeling. Multivariate partial least squares correlation analyses tested for associations between patterns of regional fractional anisotropy and cognitive functions. Univariate analyses revealed significant impairments on cognitive functions and lower fractional anisotropy in superior longitudinal fasciculus and cingulate gyrus in individuals at ultra‐high risk for psychosis. Partial least squares correlation analysis revealed different associations between patterns of regional fractional anisotropy and cognitive functions in individuals at ultra‐high risk for psychosis compared to healthy controls. Widespread higher fractional anisotropy was associated with better cognitive functioning for individuals at ultra‐high risk for psychosis, but not for the healthy controls. Furthermore, patterns of cognitive functions were associated with an interaction‐effect on regional fractional anisotropy in fornix, medial lemniscus, uncinate fasciculus, and superior cerebellar peduncle. Aberrant associations between patterns of cognitive functions to white matter may be explained by dysmyelination.

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Section: Discussionsupporting

confidence: 91%

Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra‐high risk for psychosis

Kristensen

Mandl

Raghava

et al. 2019

Human Brain Mapping

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“…Reduced FA in the body of the CC could not be attributed to other clinical variables, which supports the idea that abnormal WM microstructure in the CC might be a trait marker of BD. Indeed, reduced FA in the CC has emerged as the most robust finding in several meta-analyses in individuals with BD 11,12 and has also been reported repeatedly in unaffected REL during late adolescence 15 and adulthood. 16 The cluster we identified in REL was located in the body of the CC known to interconnect parietal and temporal cortices.…”

Section: Hypothesis 1 Alterations In Wm Microstructure a Trait Markermentioning

confidence: 86%

“…10 In adult BD, reduced FA in the anterior corpus callosum (CC) and the cingulum bundle has emerged as the most robust finding in several meta-analyses. 11,12 In addition, reduced FA in association fibers (eg, superior longitudinal fasciculus [SLF], anterior thalamic radiation [ATR]) and projection fibers (eg, uncinate fasciculus [UNC], corticospinal tract [CST]) has been frequently reported in adult BD (for review see Ref. 13 ).…”

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confidence: 99%

White matter microstructure in youth with and at risk for bipolar disorder

et al. 2020

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Objectives Bipolar disorder (BD) and familial risk for BD have been associated with aberrant white matter (WM) microstructure in the corpus callosum and fronto‐limbic pathways. These abnormalities might constitute trait or state marker and have been suggested to result from aberrant maturation and to relate to difficulties in emotion regulation. Methods To determine whether WM alterations represent a trait, disease or resilience marker, we compared youth at risk for BD (n = 36 first‐degree relatives, REL) to youth with BD (n = 36) and healthy volunteers (n = 36, HV) using diffusion tensor imaging. Results Individuals with BD and REL did not differ from each other in WM microstructure and, compared to HV, showed similar aberrations in the superior corona radiata (SCR)/corticospinal tract (CST) and the body of the corpus callosum. WM microstructure of the anterior CC showed reduced age‐related in‐creases in BD compared to REL and HV. Further, individuals with BD and REL showed in‐creased difficulties in emotion regulation, which were associated with the microstructure of the anterior thalamic radiation. Discussion Alterations in the SCR/CST and the body of the corpus callosum appear to represent a trait marker of BD, whereas changes in other WM tracts seem to be a disease state marker. Our findings also support the role of aberrant developmental trajectories of WM microstructure in the risk architecture of BD, although longitudinal studies are needed to confirm this association. Finally, our findings show the relevance of WM microstructure for difficulties in emotion regulation—a core characteristic of BD.

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“…Regarding overall white matter volume in schizophrenia, findings are inconsistent with studies showing both loss and gain of volume; however, disrupted fibre tract integrity appears to be a consistent feature (Mouchlianitis et al, ). In depression and bipolar disorder, white matter integrity is consistently impaired in the genu of the corpus callosum and posterior cingulum fibres (Dong et al, ).…”

Section: Introductionmentioning

confidence: 99%

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

Robertson

Coronado

Sethi

et al. 2019

Early Intervention Psych

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Aim: Neuropsychiatric disorders including depression, bipolar and schizophrenia frequently exhibit a neuroprogressive course from prodrome to chronicity. There are a range of agents exhibiting capacity to attenuate biological mechanisms associated with neuroprogression. This review will update the evidence for putative neuroprotective agents including clinical efficacy, mechanisms of action and limitations in current assessment tools, and identify novel agents with neuroprotective potential.Method: Data for this review were sourced from online databases PUBMED, Embase and Web of Science. Only data published since 2012 were included in this review, no data were excluded based on language or publication origin.Results: Each of the agents reviewed inhibit one or multiple pathways of neuroprogression including: inflammatory gene expression and cytokine release, oxidative and nitrosative stress, mitochondrial dysfunction, neurotrophin dysregulation and apoptotic signalling. Some demonstrate clinical efficacy in preventing neural damage or loss, relapse or cognitive/functional decline. Agents include: the psychotropic medications lithium, second generation antipsychotics and antidepressants; other pharmacological agents such as minocycline, aspirin, cyclooxygenase-2 inhibitors, statins, ketamine and alpha-2-delta ligands; and others such as erythropoietin, oestrogen, leptin, N-acetylcysteine, curcumin, melatonin and ebselen.Conclusions: Signals of evidence of clinical neuroprotection are evident for a number of candidate agents. Adjunctive use of multiple agents may present a viable avenue to clinical realization of neuroprotection. Definitive prospective studies of neuroprotection with multimodal assessment tools are required.

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Shared abnormality of white matter integrity in schizophrenia and bipolar disorder: A comparative voxel-based meta-analysis

Cited by 69 publications

References 85 publications

Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra‐high risk for psychosis

Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra‐high risk for psychosis

White matter microstructure in youth with and at risk for bipolar disorder

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

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