Shaping the Genome with Non-coding RNAs

Wang, Xue Qing David; Crutchley, Jennifer Lynn; Dostie, Josée

doi:10.2174/9781681081731116040006

Cited by 1 publication

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“…By defining the accessibility to chromatin, histone modifications demarcate amenable or silenced chromatin domains which ultimately reflect the activity of gene transcription. An intimate relationship exists between lncRNAs and chromatin conformation [ 11 , 12 ]. LncRNAs regulate chromatin modifications by recruiting or directly interacting with histone-modifying complexes or enzymes at specific chromosomal loci; these in turn modulate gene transcription [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Lncrnas Regulate Alternative Splicing Through Chromatin Mmentioning

confidence: 99%

Epigenetic Regulation of Alternative Splicing: How LncRNAs Tailor the Message

Pisignano

Ladomery

2021

ncRNA

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Alternative splicing is a highly fine-tuned regulated process and one of the main drivers of proteomic diversity across eukaryotes. The vast majority of human multi-exon genes is alternatively spliced in a cell type- and tissue-specific manner, and defects in alternative splicing can dramatically alter RNA and protein functions and lead to disease. The eukaryotic genome is also intensively transcribed into long and short non-coding RNAs which account for up to 90% of the entire transcriptome. Over the years, lncRNAs have received considerable attention as important players in the regulation of cellular processes including alternative splicing. In this review, we focus on recent discoveries that show how lncRNAs contribute significantly to the regulation of alternative splicing and explore how they are able to shape the expression of a diverse set of splice isoforms through several mechanisms. With the increasing number of lncRNAs being discovered and characterized, the contribution of lncRNAs to the regulation of alternative splicing is likely to grow significantly.

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