Shapeshifters in Pathology: Paratesticular Solitary Fibrous Tumor Mimicking Leiomyoma

Hogan, Matthew E; Psutka, Sarah P.; Liu, Yajuan J.; Tretiakova, Maria

doi:10.1177/10668969221091585

Cited by 1 publication

(2 citation statements)

References 15 publications

(27 reference statements)

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“…Various diagnostic differentials of typical SFT considered in our study, especially on core biopsies included commonly synovial sarcoma, gastrointestinal stromal tumor (GIST) and dermatofibrosarcoma protuberans (DFSP), and also occasionally schwannoma, cellular hemangioma, fibromatosis, myoepithelioma and leiomyoma, more so at uncommon sites for SFTs. Malignant peripheral nerve sheath tumor (MPNST), melanoma, synovial sarcoma and at times DFSP also need to be primarily excluded before arriving at the diagnosis of traditionally described malignant SFT (Table 9 ) [ 33 - 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Exploring Solitary Fibrous Tumors at a Tertiary Cancer Center: Clinicopathological and Immunomorphologic Profile

Chowdhury,

Mishrikotkar,

Nehra

et al. 2024

Cureus

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Background Solitary fibrous tumor (SFT) is a distinct fibroblastic tumor that can occur at any anatomical site and can manifest a variety of histopathological features. NAB2-STAT6 gene fusion has recently emerged as a sensitive and specific molecular marker and its surrogate on immunohistochemistry, STAT6 has also displayed considerable efficacy. Nevertheless, its histologic diversity can result in diagnostic challenges, especially when classic features are not apparent. Methods A retrospective study was conducted at a tertiary cancer centre in North India over 3 years to document the clinicopathologic and immunomorphologic profile of SFTs. Immunohistochemical analysis of BCOR and p53 were gauged additionally and patients were stratified according to Modified Demicco and Salas criteria for risk of metastasis. Results Sixteen patients of SFT were identified, affecting middle-aged men and women equally. Though lung/pleura are known to be involved commonly, SFT affects other sites such as the kidney, brain, buccal mucosa, liver, and penis as well. The majority endured localized disease while a lesser number suffered locoregional/distant spread. Two patients revealed features of a malignant profile. Risk stratification according to the Modified Demicco and Salas criteria evinced comparable results. No discernible relationship however was highlighted between the immunohistochemical expression of BCOR, p53, and any significant SFT parameter. Conclusion Although SFTs are very rare substantially benign mesenchymal neoplasms, pathologists must be conversant with their histological diversity and be vigilant of their malignant attributes. The worth of STAT6 immunohistochemistry for precise diagnosis and long-term studies for delineating clinical behavior cannot be overemphasized.

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Section: Discussionmentioning

confidence: 99%

“…Malignant peripheral nerve sheath tumor (MPNST), melanoma, synovial sarcoma and at times DFSP also need to be primarily excluded before arriving at the diagnosis of traditionally described malignant SFT (Table 9) [33][34][35][36][37].…”

Section: Additional Information Author Contributionsmentioning

confidence: 99%